Endothelial Function Increases after a 16-Week Diet and Exercise Intervention in Overweight and Obese Young Women

Cotie, Lisa M.; Josse, Andrea R.; Phillips, Stuart M.; MacDonald, Maureen J.

doi:10.1155/2014/327395

Cited by 19 publications

(16 citation statements)

References 55 publications

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“…Although this was an unexpected finding, it is consistent with observations from other exercise studies. 13,44 In addition, vasodilator responses to NTG after SWL were unaltered after CRT, suggesting that any changes in FMD were not related to changes in the vessels' sensitivity to NO. Resistance training may enhance conduit artery EF independently through direct mechanical effects of recurrent wall shear stress on NO production.…”

Section: Discussionmentioning

confidence: 98%

“…38,[40][41][42] Repetitive increases in flow during habitual exercise training have been shown to improve FMD, which is indicative of enhanced NO-mediated EF. 24,43,44 There is a plethora of research demonstrating that aerobic training enhances EF in overweight and obese adults, 45,46 but few studies have investigated the specific effects of resistance training. For this study, we implemented an exercise intervention by way of CRT using progressive overload and showed that vascular protection after acute resistance exercise is afforded after 8 weeks of training.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have suggested that inflammation and oxidative stress are not altered by habitual resistance exercise, 13,44 but direct measures of other inflammatory mediators (e.g., interleukin-6 and interleukin-1b) will require additional analysis. Although FMD is linked to NO bioavailability and impairments are likely due to reductions in NO, further studies should include measures of NO and oxidative stress.…”

Section: Study Limitationsmentioning

confidence: 99%

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Circuit Resistance Training Attenuates Acute Exertion-Induced Reductions in Arterial Function but Not Inflammation in Obese Women

Franklin

Robinson

Bian

et al. 2015

Metabolic Syndrome and Related Disorders

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Background: Cardiovascular disease (CVD) is a leading cause of preventable death among young women in the United States. Habitual resistance exercise training is known to have beneficial effects on endothelial function and CVD risk factors, including obesity; however, previous studies show that acute resistance exercise impairs endothelial function in obese adults who are sedentary, a response that may be linked to inflammation. We sought to determine if circuit-based resistance training (CRT) attenuates acute resistance exercise-induced reductions in endothelial function in a population of young, obese, sedentary women and whether or not inflammation plays a role in this response.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Study Limitationsmentioning

confidence: 99%

See 1 more Smart Citation

Circuit Resistance Training Attenuates Acute Exertion-Induced Reductions in Arterial Function but Not Inflammation in Obese Women

Franklin

Robinson

Bian

et al. 2015

Metabolic Syndrome and Related Disorders

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“…Similarly, Mavri et al (15) found that weight reduction by low-calorie diet in obese adults might contribute to the improvement in endothelial function, as noted by a decrease in endothelin-1. Lastly, Cotie et al (16) reported that endothelial function increases after a 16-week diet and exercise intervention in overweight and obese women.…”

Section: Discussionmentioning

confidence: 99%

Circuit resistance training improved endothelial dysfunction in obese aged women

Rosety¹,

Pery²,

Rosety³

et al. 2016

Nutr Hosp

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ResumenIntroducción: recientes estudios han confirmado que el entrenamiento de fuerza en circuito podría reducir la masa grasa visceral en mujeres mayores obesas. Para seguir avanzando en esta línea de trabajo, nos propusimos determinar su impacto en marcadores de disfunción endotelial. Material y método: participaron voluntariamente 48 mujeres (70-75 años) con obesidad procedentes de la comunidad. De ellas, 24 fueron asignadas aleatoriamente al grupo experimental para desarrollar un programa de entrenamiento de fuerza en circuito de 6 estaciones durante 12 semanas con 3 sesiones/semana. Los marcadores de disfunción endotelial ensayados fueron: endotelina-1, molécula de adhesión intercelular-1 (ICAM-1) y molécula de citoadhesión vascular-1 (VCAM-1). Asimismo se evaluó su influencia en un test funcional para población mayor como el de sentarse-levantarse en 30 segundos. Este protocolo fue aprobado por un comité de ética institucional. Resultados: tras completar el programa de intervención se observó un descenso significativo de los niveles plasmáticos de entotelina-1 (2,28 ± 0,7 vs. 1,98 ± 1,1 pg/ml; p = 0,019; d = 0,67) e ICAM-1 (290 ± 69 vs. 255 ± 76 ng/ml; p = 0,004; d = 0,92). También mejoró significativamente la puntuación del test funcional (18,7 ± 3,1 vs. 23,0 ± 3,6 repeticiones; p = 0,019; d = 0,98). Por el contrario, no se observaron cambios en el grupo control. Conclusión: el entrenamiento de fuerza en circuito mejora la disfunción endotelial presente en mujeres mayores obesas. Futuros estudios siguen siendo necesarios para consolidar su aplicación en clínica.Circuit resistance training improved endothelial dysfunction in obese aged women AbstractIntroduction: It is widely accepted that obesity is associated with endothelial dysfunction. In a recent paper, we have also found circuit resistance training may reduce visceral fat in obese aged women. Accordingly, the current study was conducted to ascertain the effects of circuit resistance training on markers of endothelial dysfunction in this population group. Methods: In the present interventional study, a total of 48 obese aged women were recruited from the community. Twenty-four of them were randomly assigned to perform a 12-week resistance circuit training programme, 3-days per week. This training was circularly performed in 6 stations: arm curl, leg extension, seated row, leg curl, triceps extension and leg press. The Jamar handgrip electronic dynamometer was used to assess maximal handgrip strength of the dominant hand. Lastly, serum samples were analysed using an immunoassay (ELISA) for endothelin-1, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).Results: When compared to baseline, resistance training significantly reduced serum levels of endothelin-1 (2.28 ± 0.7 vs. 1.98 ± 1.1 pg/ml; p = 0.019; d = 0.67) and ICAM-1 (290 ± 69 vs. 255 ± 76 ng/ml; p = 0.004; d = 0.92) in the experimental group. No significant changes in any of the tested outcomes were found in the control group. Conclusion: A short-term cir...

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“…The main finding of the present study was that weightreducing program ameliorated inflammatory cytokines (TNF-α, IL-6 and CRP) and markers of endothelial function (ICAM-1 VCAM-1 and tPA) in obese postmenopausal women as a result of weight loss, these results are in line with many previous studies. Cotie and colleagues demonstrated that, sixteen weeks of a combined training by aerobic and resistance exercises in addition to diet resulted in improved interleukin-6 (IL-6) and endothelial function in overweight and obese young women because of weight loss 20 .…”

Section: Discussionmentioning

confidence: 99%

Weight loss improves biomarkers endothelial function and systemic inflammation in obese postmenopausal Saudi women

El-Kader

Al-Dahr²

2016

Afr H. Sci.

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Background: Although postmenopausal associated disorders are important public health problems worldwide, to date limited studies evaluated the endothelial function and systemic inflammation response to weight loss in obese postmenopausal women. Objective: This study was done to evaluate the endothelial function and systemic inflammation response to weight loss in obese postmenopausal Saudi women. Material and methods: Eighty postmenopausal obese Saudi women (mean age 52.64±6.13 year) participated in two groups: Group (A) received aerobic exercise on treadmill and diet whereas, group (B) received no intervention. Markers of inflammation and endothelial function were measured before and after 3 months at the end of the study. Results:The values of body mass index(BMI), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), inter-cellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and plasminogen activator inhibitor-1 activity (PAI-1:Ac) were significantly decreased in group (A), while changes were not significant in group (B). Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment. Conclusion: Weight loss ameliorates inflammatory cytokines and markers of endothelial function in obese postmenopausal Saudi women.

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Endothelial Function Increases after a 16-Week Diet and Exercise Intervention in Overweight and Obese Young Women

Cited by 19 publications

References 55 publications

Circuit Resistance Training Attenuates Acute Exertion-Induced Reductions in Arterial Function but Not Inflammation in Obese Women

Circuit Resistance Training Attenuates Acute Exertion-Induced Reductions in Arterial Function but Not Inflammation in Obese Women

Circuit resistance training improved endothelial dysfunction in obese aged women

Weight loss improves biomarkers endothelial function and systemic inflammation in obese postmenopausal Saudi women

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