Circuit Resistance Training Attenuates Acute Exertion-Induced Reductions in Arterial Function but Not Inflammation in Obese Women

Abstract

Background: Cardiovascular disease (CVD) is a leading cause of preventable death among young women in the United States. Habitual resistance exercise training is known to have beneficial effects on endothelial function and CVD risk factors, including obesity; however, previous studies show that acute resistance exercise impairs endothelial function in obese adults who are sedentary, a response that may be linked to inflammation. We sought to determine if circuit-based resistance training (CRT) attenuates acute resistance exercise-induced reductions in endothelial function in a population of young, obese, sedentary women and whether or not inflammation plays a role in this response.

Improved arterial flow-mediated dilation after exertion involves hydrogen peroxide in overweight and obese adults following aerobic exercise training

“…Our primary outcome measures exceed these minimum effect sizes. In addition, the findings of this study align with previous studies of similar size and using a similar study population from our lab [10,15,18]. Nonetheless, the relationship between regular exercise and various stressors shown to induce vasodilator dysfunction remains an area that needs further exploration, particularly in the microvasculature during obesity.…”

“…Brachial FMD is a surrogate of conduit artery endothelial cell function that has been found to be related to coronary artery function and to predict cardiovascular events [5,6]. The magnitude and duration of dysfunction is dependent upon fitness level and age [7][8][9][10].…”

“…Despite previous findings of conduit artery and microvessel vasodilator dysfunction following acute exertion in a number of populations [10][11][12]15], there is limited data on the ability of regular moderate-intensity aerobic exercise training (AET) to prevent acute exertion-induced arterial dysfunction in obese individuals. Therefore, we sought to determine if 8 weeks of moderate-intensity aerobic exercise (aerobic training) could prevent post acute physical exertion-induced large artery and microvessel dysfunction in sedentary overweight and obese individuals.…”

Short-term regular aerobic exercise reduces oxidative stress produced by acute high intraluminal pressure in the adipose microvasculature

“…However, acute exercise bouts paradoxically increase the risk of cardiovascular events in sedentary individuals, in part through a transient increase in blood pressure and endothelial dysfunction (2,9,15). Extensive work characterizing subcutaneous adipose resistance arteries has been done in humans (22,24,40), demonstrating that endothelium-dependent vasodilation in these arteries correlates with clinical measures of peripheral vascular function (6), that high intraluminal pressure elicits endothelial dysfunction in these arteries (9,40), and that regular exercise may be protective against said endothelial dysfunction (16,40).…”

Exploring Vascular Function Biomarkers: Implications for Rehabilitation

“…However, in another study, Franklin et al [46] showed that acute physical stress induced by resistance exercise reduces FMD in sedentary obese women, suggesting that this response to acute physical exertion may be an important marker for CV risk prediction in this population.…”