A new xanthone derivative from twigs of Garcinia nobilis

Abstract

Phytochemical investigation of the twigs of Garcinia nobilis led to the isolation of a new xanthone, named l-hydroxy-2,5-dimethoxyxanthone (1), together with 15 known compounds (2 -16). The structures of the new and known compounds were established by means of spectroscopic methods and by comparison with previously reported data. The structure of compound 1 was confirmed by X-ray diffraction data. Compounds 1 -16 were tested for their cytotoxic activity against human cervix carcinoma cell line KB-3-1. Compounds 5 and 11 showed moderate activity while others showed weak biological activity in these cytotoxicity assays. Compounds 4 and 9 were found to be inactive.

Heptacyclosordarianone, a New Polyketide From Sordaria sp., an Endophytic Fungus From Garcinia polyantha

“…Based on an agar diffusion method, 15 the antibacterial activity of all compounds was tested against Escherichia coli DSMZ 1058, Bacillus subtilis DSMZ 704, Micrococcus luteus DSMZ 1605, Cell-based cytotoxicity assays of all isolated compounds against the human cervix carcinoma cell line KB-3-1 in a resazurin assay was undertaken according to our previous study. 16 However, all the tested compounds were found to be inactive against the KB-3-1 cell line.…”

“…Cell-based cytotoxicity assays of all isolated compounds against the human cervix carcinoma cell line KB-3-1 in a resazurin assay was undertaken according to our previous study. 16 However, all the tested compounds were found to be inactive against the KB-3-1 cell line.…”

“…The cytotoxicity of 1-3 against the human cervix carcinoma cell line KB-3-1 was evaluated as previously reported. 16 The KB-3-1 cells were cultivated in 1 layer in Dulbecco's Modified Eagle medium with glucose (4.5 g/L), l-glutamine, sodium pyruvate, and phenol red, supplemented with 10% fetal bovine serum (FBS). The cells were then maintained at 37 °C in 5.3% carbon dioxide (CO 2 ) humidified air.…”

Anti-mycobacterial activity of polyketides from Penicillium sp. endophyte isolated from Garcinia nobilis against Mycobacteriumsmegmatis

“…nobilis is found in the Southwest Region of Cameroon and is known to be a rich source of bioactive xanthones [16,17]. Similar to the small peptides, polyketides constitute a large proportion of industrial antibiotics.…”

Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl.

“…Guttiferones have been reported as anti-HIV, trypanocidal and cytotoxic agents (Gustafson et al 1992;Komguem et al 2005;Merza et al 2006). Our previous studies of the chemistry of Garcinia nobilis led to the isolation of xanthones derivatives including the isolation from the leaves of d l-hydroxy-2,5-dimethoxyxanthone with cytotoxic activity against human cervix carcinoma cell line KB-3-1 (Fouotsa et al 2014). We also isolated caroxanthone from the stem bark of G. nobilis which exhibited a-glucosidase and antibacterial activities but did not showed any a-chymotrypsin inhibitory activity (Fouotsa et al 2012;.…”