Anti-mycobacterial activity of polyketides from Penicillium sp. endophyte isolated from Garcinia nobilis against Mycobacteriumsmegmatis

Jouda, Jean-Bosco; Mawabo, Isabelle Kamga; Notedji, Augustin; Mbazoa, Céline Djama; Nkenfou, Jean; Wandji, Jean; Nkenfou, Céline Nguefeu

doi:10.1016/j.ijmyco.2016.02.007

Cited by 32 publications

(15 citation statements)

References 21 publications

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“…Penialidin C produced by endophytic fungi Penicillium sp. showed antimycobacterial activity against M. smegmatis [26]. Strain SxF1 was found to be closely related to Streptomyces harbinensis (99.51%), SxL6 was closely related to Streptomyces herbinensis (99.76%).…”

Section: Resultsmentioning

confidence: 99%

In-vitro Antimycobacterial Activities of Endophytic Bacteria Associated with Medicinal Plant of Manipur

Tamreihao¹

2017

JBMOA

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Section: Resultsmentioning

confidence: 99%

In-vitro Antimycobacterial Activities of Endophytic Bacteria Associated with Medicinal Plant of Manipur

Tamreihao¹

2017

JBMOA

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“…were found to be most effective in inhibition of Mycobacterium sp. with MIC of 15.6 and 31.2 µg/mL respectively (Jouda et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Antimycobacterial potential of resorcinol type lipid isolated from Chaetomium cupreum, an endophytic fungus from Mussaenda luteola

Shylaja

Sasikumar

Arunachalam

2018

Bangladesh J Pharmacol

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An endophytic fungus Chaetomium cupreum was isolated from the ornamental plant Mussaenda luteola. A known metabolite named resorcinol type of lipid (compound 1) was isolated using column chromatography and structurally elucidated by spectroscopic studies includes UV-Vis, FT-IR, NMR, MS analysis and comparing with the existing data. The compound 1 was evaluated for antimycobacterial potential by microtitre plate alamar blue assay against Mycobacterium tuberculosis H37Rv (ATCC27294). It also estimated for DPPH free radical scavenging and antibacterial (agar well diffusion method) potentials. Compound 1 revealed to have significant inhibition of Mycobacterium with MIC of 6.3 µg/mL which is similar to the standard streptomycin drug. It also exhibited good DPPH free radical scavenging potential of 84.5 ± 0.4% and maximum inhibition of both E. coli (ATCC 25922) as well as S. aureus (ATCC 25923). Thus, endophytic fungus C. cupreum from Mussaenda luteola could be a potential source of novel lead antimicrobial agents for drug discovery.Video Clip of Methodology:9 min 43 sec: <a href="https://www.youtube.com/v/jVjoCzsGMg8">Full Screen</a> <a href="https://www.youtube.com/watch?v=jVjoCzsGMg8">Alternate</a>

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“…De Prince et al (2012) and Gamboa-Angulo et al (2013) studied extracts from various fungal species for antimycobacterial activity and found them to possess anti-Mycobacterium tuberculosis activity. Jouda et al (2016) isolated various compounds produced by an endophytic fungus of Penicillium species harbored in Garcinia nobilis, and were found to be active against Mycobacterium smegmatis.…”

Section: Cytotoxic Activitiesmentioning

confidence: 99%

Antimycobacterial and cytotoxic activities of extracts from fungal isolates of Lake Magadi

Kowanga¹,

Munissi²,

Masalu³

et al. 2018

Int. J. Bio. Chem. Sci

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In this study, antimycobacterial and cytotoxic activities of ethyl acetate extracts of fungal isolates from Lake Magadi were evaluated. The extracts were tested against Mycobacterium madagascariense (MM) and M. indicus pranii (MIP), and cytotoxicity against brine shrimp (Artemia salina) larvae. Fungal strains were identified using sequence comparison of the Internal Transcribed Spacer (ITS) region. Potent antimycobacterial activities against MM were exhibited by extracts from Volutella colletotrichoides, Helicoon richonis, Penicillium limosum, P. sacculum, Aspergillus parasiticus and A. nomius strains that exhibited minimum inhibition concentration (MIC) in the range of 0.19 -12.5 mg/mL. On the other hand, significant antimycobacterial effects against MIP was shown by extracts from V. colletotrichoides, H. richonis, A. parasiticus, Fusarium merismoides, A. silvaticus and A. fumigatus strains in the same MIC range. Notable cytotoxic activities of the extracts were from A. versicolor, A. nomius, P. janthinellum and H. richonis strains with LC 50 values ranging from 46.60 -98.12 μg/mL. These results indicate that fungi inhabiting Lake Magadi have the ability to produce bioactive metabolites that could be further explored for potential medicinal agents.

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Anti-mycobacterial activity of polyketides from Penicillium sp. endophyte isolated from Garcinia nobilis against Mycobacteriumsmegmatis

Cited by 32 publications

References 21 publications

In-vitro Antimycobacterial Activities of Endophytic Bacteria Associated with Medicinal Plant of Manipur

In-vitro Antimycobacterial Activities of Endophytic Bacteria Associated with Medicinal Plant of Manipur

Antimycobacterial potential of resorcinol type lipid isolated from Chaetomium cupreum, an endophytic fungus from Mussaenda luteola

Antimycobacterial and cytotoxic activities of extracts from fungal isolates of Lake Magadi

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