Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis Engl.

Abstract

A new xanthone, mboudiexanthone (1), together with five known compounds, euxanthone (2), isogarcinol (3), garcinol (4), betulinic acid (5) and zeorin (6) were isolated from the leaves of Garcinia nobilis Engl. The structures were determined by 1D and 2D NMR techniques and X-ray diffraction for 6. The in vitro antiproliferative properties of isolated compounds were evaluated against the human breast cancer cell line MCF-7. All compounds showed an antiproliferative activity with an IC 50 value down to $11 mM for isogarcinol.

New Compounds from Terrestrial Plants: A Perspective View

“…One new xanthone was isolated from Garcinia nobilis Engl. leaf extract [40]. From the flower and twig extracts of Garcinia mckeaniana, a new biphenyl and one new simple xanthone were reported [41], and in studies using the fruit extract of Garcinia cambogia, ten new polyisoprenylated benzophenone derivatives were isolated and tested for their biological activity [42].…”

“…Figure 9. New abietane diterpenoids chemical structures.Pimarane(38 and 39) and abietane(40) diterpenoids were obtained from the aerial parts of Blumea balsamifera (L.) DC (Asteraceae)[83] (Figure10). The compounds showed anti-inflammatory action by inhibiting TNF-α induced by LPS.…”

New Compounds from Plants: A Perspective View

“…One new xanthone was isolated from Garcinia nobilis Engl. leaves extract [40]. From the flower and twig extracts of Garcinia mckeaniana a new biphenyl and one new simple xanthone was reported [41], and in studies using the fruits extract of Garcinia cambogia, ten new polyisoprenylated benzophenone derivatives were isolated and tested for their biological activity [42].…”