Safflower yellow injection combined with conventional therapy in treating unstable angina pectoris: a meta-analysis

Kong, Dezhao; Zhang, Zhe; Xiao, Liu; Yuan, Daoxian; Liu, Yue; Yang, Guanlin

doi:10.1016/s0254-6272(14)60021-2

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…Injectable Safflower extract is widely used in Chinese medicine, particularly for the treatment of cerebrovascular and cardiovascular diseases, 9 and has been approved as a medicinal drug by the State Food and Drug Administration since 2005. 10 Hydroxysafflor yellow A (HSYA), which is the main chemical component of safflower, has been shown to possess many pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 Although the exact mechanism underlying PAH is not fully understood, studies using monocrotaline (MCT)-induced models of PAH suggest that inflammatory status and oxidative stress are the main contributors to disease pathogenesis; 6 pulmonary vascular remodelling can be attenuated through inhibition of pulmonary inflammatory cell proliferation and leukocyte infiltration; 7 and alleviating oxidative stress can prevent pulmonary vascular remodeling. 8 Injectable Safflower extract is widely used in Chinese medicine, particularly for the treatment of cerebrovascular and cardiovascular diseases, 9 and has been approved as a medicinal drug by the State Food and Drug Administration since 2005. 10 Hydroxysafflor yellow A (HSYA), which is the main chemical component of safflower, has been shown to possess many pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

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Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats

et al. 2016

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ObjectiveTo evaluate the beneficial effects of hydroxysafflor yellow A (HSYA) on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats, and to investigate the main pathophysiological mechanism of HSYA in preventing development of MCT-induced PAH.MethodsFour groups (control, control with HSYA treatment, MCT-exposed, and MCT-exposed with HSYA treatment) were evaluated at day 28 following MCT exposure. Haemodynamic measurements, right ventricular hypertrophy, morphometry, inflammatory cytokines and oxidant expression were assessed.ResultsHSYA significantly reduced haemodynamic changes, right ventricular hypertrophy and morphometric changes induced by exposure to MCT. HYSA also suppressed MCT-induced inflammation and oxidative stress in rat pulmonary tissue.ConclusionsExperimental MCT-induced PAH may be reduced by HSYA treatment, and the mechanism may involve suppression of inflammation and oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats

et al. 2016

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“…Carthamus tinctorius injection ( CTI) (2.5 and 0.625 g/kg) significantly inhibited the typical ECG S-T segment elevation, reduced concentration of IL-6 and TNF-α in serum, suppressed over expression of Bax protein and also inhibited the reduction of BCl-2 expression and markedly depressed the Bax/Bcl-2 ratio in isoprenaline-induced acute myocardial ischemia (AMI). These findings demonstrate that CTI is cardioprotective against AMI in rats and is likely to related to decrease inflammatory response mediated by TNF-α and IL-6, down-regulate protein level of Bax and up-regulate that of Bcl-2 in the heart tissue (43) .…”

Section: Carthamus Tinctoriusmentioning

confidence: 64%

Medicinal plants with beneficial effects on heart

Al-Snafi¹

2022

GSC Biol. and Pharm. Sci.

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Cardiovascular diseases (CVDs) kill 17.9 million people per year, by 2030, it is predicted that more than 22.2 million people will die annually from CVDs. Many medicinal plants possessed cardiac and anti-arrhythmic effects. The current study was designed to highlight the medicinal plants which possess beneficial effect in heart failure, protect heart from the toxicity of wide range of chemicals, and exert anti-arrhythmic activities.

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“…HSYA injections have been recently reported to be effective as an adjuvant drug in the management of angina pectoris [9,87,88].…”

Section: Abirritationmentioning

confidence: 99%

“…HSYA injections have been recently reported to be effective as an adjuvant drug in the management of angina pectoris [ 9 , 87 , 88 ]. The proposed mechanisms of action include regulating the intracellular flow of Ca 2+ , promoting blood circulation, vasodilation, and increasing blood supply for tissue and organs.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Pharmacological Activities of Safflower Yellow and Its Clinical Applications

Yan

Wen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Safflower is an annual herb used in traditional Chinese herbal medicine. It consists of the dried flowers of the Compositae plant safflower. It is found in the central inland areas of Asia and is widely cultivated throughout the country. Its resistance to cold weather and droughts and its tolerance and adaptability to salts and alkalis are strong. Safflower has the effect of activating blood circulation, dispersing blood stasis, and relieving pain. A natural pigment named safflower yellow (SY) can be extracted from safflower petals. Chemically, SY is a water-soluble flavonoid and the main active ingredient of safflower. The main chemical constituents, pharmacological properties, and clinical applications of SY are reviewed in this paper, thereby providing a reference for the use of safflower in preventing and treating human diseases. Methods. The literature published in recent years was reviewed, and the main chemical components of SY were identified based on chemical formula and structure. The pharmacological properties of hydroxysafflor yellow A (HSYA), SYA, SYB, and anhydrosafflor yellow B (AHSYB) were reviewed. Results. The main chemical constituents of SY included HSYA, SYA, SYB, and AHSYB. These ingredients have a wide range of pharmacological activities. SY has protective effects on the heart, kidneys, liver, nerves, lungs, and brain. Moreover, its effects include, but are not limited to, improving cardiovascular and cerebrovascular diseases, abirritation, regulating lipids, and treating cancer and diabetic complications. HSYA is widely recognised as an effective ingredient to treat cardiovascular and cerebrovascular diseases. Conclusion. SY has a wide range of pharmacological activities, among which improving cardiovascular and cerebrovascular diseases are the most significant.

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Safflower yellow injection combined with conventional therapy in treating unstable angina pectoris: a meta-analysis

Abstract: Safflower yellow injection as an adjunct therapy with conventional drugs shows advantages in easing the clinical symptoms of unstable angina and improving ECG over basic therapy alone. However, the conclusions should be interpreted with care until more high-quality RCTs are reported.

Cited by 8 publications

References 5 publications

Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats

Hydroxysafflor yellow A improves established monocrotaline-induced pulmonary arterial hypertension in rats

Medicinal plants with beneficial effects on heart

Pharmacological Activities of Safflower Yellow and Its Clinical Applications

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