Taro corms mucilage/HPMC based transdermal patch: An efficient device for delivery of diltiazem hydrochloride

Sarkar, Gunjan; Saha, Nayan Ranjan; Roy, Indranil; Bhattacharyya, Amartya; Bose, Moumita; Mishra, Roshnara; Rana, Dipak; Bhattacharjee, Debashis; Chattopadhyay, Dipankar

doi:10.1016/j.ijbiomac.2014.02.024

Cited by 64 publications

(24 citation statements)

References 30 publications

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“…of leaf powder taken Identification Test: About 2 ml of aqueous extract of the mucilage was prepared and about 2.5 ml of absolute alcohol added to it 15 . The presence of mucilage in the extracted material was confirmed by performing Molisch's and Ruthenium red 16 .…”

Section: Quantification Of Mucilagementioning

confidence: 95%

Untitled

2018

IJPSR

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Plant mucilages have found wide application in food, pharmaceutical and cosmetic industries. Hence, it would be worthwhile to characterise the physical and chemical attributes of mucilages from commonly available plants for their beneficial utilization. Hibiscus rosasinensis Linn. (Family Malvaceae), widely grown as an ornamental throughout the tropics and subtropicsis a good source of mucilage. The present study focuses on the extraction of the mucilage from the leaves of Hibiscus rosa-sinensis, its subsequent quantification and physico-chemical characterisation. A protocol was presently standardized for the yield optimization of mucilage from Hibiscus through detection of an appropriate maceration temperature and precipitation solvent. Further analyses revealed ideal pH value, swelling index, flow properties and particle size of Hibiscus mucilage. Moreover, chemical, FTIR spectral and electrokinetic data of Hibiscus mucilage revealed that it can be considered as a suitable blending ingredient in composites with potential industrial applications. INTRODUCTION: Mucilages are normal metabolic products formed from sugars and uronic acid units in plant cells. Hydrophilic nature of mucilagenous plant parts becomes evident from the viscous and slimy mass it forms when dissolved in water 1. Some of the mucilage rich plants are Aloe vera, Abelmoschus esculentus, Trigonella foenumgraceum, Asparagus racemosus, Lepidium sativum, Salvia hispanica, Althaea officinalis and Hibiscus rosa-sinensis 2, 3. Generally, mucilages are merely considered as carbohydrate reserves in plant cells. However, reports show that they provide additional physiological benefits to plants including frost tolerance, water transport, wound response, plant host-pathogen interaction and maintenance of ionic balance of plant cells 4, 5 .

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Section: Quantification Of Mucilagementioning

confidence: 95%

Untitled

2018

IJPSR

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“…This may be due to the good solubility of drug in hydrophilic polymer (in this case HPMC K4M). In addition, entrapment of drug molecules in the polymeric chain leads to sustained release of the drug from the films [9]. Numbers of white spots were observed in case of aged film (Fig.…”

Section: Scanning Electron Microscopic (Sem) and Stability Studiesmentioning

confidence: 93%

“…6a). A clear and smooth film surface in case of fresh film indicates uniform distribution of drug in the polymer matrix having equal amount of hydrophilic and hydrophobic polymers [9]. This may be due to the good solubility of drug in hydrophilic polymer (in this case HPMC K4M).…”

Section: Scanning Electron Microscopic (Sem) and Stability Studiesmentioning

confidence: 98%

“…The main aim of the folding endurance study is to test the ability of the film to endure rupture during the application and use [9]. The folding endurance values were ranged from 240.25 ± 7.4 in case of DF1 to 210.1 ± 5.78 in case of DF5 (Table 3).…”

Section: Folding Endurancementioning

confidence: 99%

“…Out of various transdermal drug delivery systems such as matrix, reservoir, microreservoir, membrane matrix hybrid and adhesive, matrix diffusion type is widely accepted because of its ease of manufacturing. Many researchers have successfully developed films of DTH using combination of different polymers including ethyl cellulose-PVP, Eudragit-PVP-PEG 4000, HPMC-EC [8], taro corn mucilage-HPMC [9] and PVA-xanthan gum [5].…”

Section: Introductionmentioning

confidence: 99%

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Transdermal delivery of Diltiazem HCl from matrix film: Effect of penetration enhancers and study of antihypertensive activity in rabbit model

Parhi

Suresh²

2016

Journal of Advanced Research

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The present investigation focused on the development of Diltiazem HCl (DTH) matrix film and its characterization by in-vitro, ex-vivo and in-vivo methods. Films were prepared by solvent casting method by taking different ratios of hydroxypropyl methylcellulose K4M (HPMC K4M) and Eudragit RS100. Various parameters of the films were analyzed such as mechanical property using tensile tester, interaction study by Fourier transform infrared spectroscopy (FTIR) and Thermogravimetric analysis (TGA), in-vitro drug release through cellulose acetate membrane, ex-vivo permeation study using abdominal skin of rat employing Franz diffusion cell, and in-vivo antihypertensive activity using rabbit model. The FTIR studies confirmed the absence of interaction between DTH and selected polymers. Thermal analysis showed the shifting of endothermic peak of DTH in film, indicating the dispersion of DTH in molecular form throughout the film. Incorporation of 1,8-cineole showed highest flux (89.7 μg/cm(2)/h) of DTH compared to other penetration enhancers such as capsaicin, dimethyl sulfoxide (DMSO), and N-methyl pyrrolidone (NMP). Photomicrographs of histology study on optimized formulation (DF9) illustrated disruption of stratum corneum (SC) supporting the ex-vivo results. The in-vivo antihypertensive activity results demonstrated that formulation DF9 was effective in reducing arterial blood pressure in normotensive rabbits. SEM analysis of films kept for stability study (40 ± 2 °C/75% ± 5%RH for 3 months) revealed the formation of drug crystals which may be due to higher temperature. The findings of the study provide a better alternative dosage form of DTH for the effective treatment of hypertension with enhanced patient compliance.

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