Pharmaceutical Applications of Natural Polymers

Nayak, Atul; Olatunji, Ololade; Das, Diganta Bhusan; Vladisavljević, Goran T.

doi:10.1007/978-3-319-26414-1_9

Cited by 9 publications

(8 citation statements)

References 203 publications

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“…Several studies deal with HA-based devices composed of other biopolymers such as heparin, silk fibroin [ 107 ], chitosan [ 12 , 132 , 138 , 139 , 140 , 141 ], collagen [ 132 , 142 , 143 ] and alginate [ 11 , 144 ], or synthetic ones like poly(methylvinylether-alt-maleic acid [ 133 ], polycaprolactone [ 145 , 146 ], PDLLA [ 147 ], PEG [ 148 ] and poloxamer [ 95 , 126 , 127 , 128 ]. These composite scaffolds made of natural polymers are biocompatible systems that exhibit interesting properties for tissue engineering applications such as structure, porosity, stiffness and correct controlled degradation rates [ 14 , 149 ]. Natural macromolecules exhibit abilities for site-specific cell adhesion, and given that HA is the main component of the brain ECM, neural cells can interact with a matrix which mimics their natural environment [ 3 , 10 , 14 ].…”

Section: Ha-based Specific Device For Various Applicationsmentioning

confidence: 99%

Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders

Djoudi

Molina-Peña²,

Ferreira³

et al. 2022

IJMS

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Hyaluronic acid (HA) is a Glycosaminoglycan made of disaccharide units containing N-acetyl-D-glucosamine and glucuronic acid. Its molecular mass can reach 10 MDa and its physiological properties depend on its polymeric property, polyelectrolyte feature and viscous nature. HA is a ubiquitous compound found in almost all biological tissues and fluids. So far, HA grades are produced by biotechnology processes, while in the human organism it is a major component of the extracellular matrix (ECM) in brain tissue, synovial fluid, vitreous humor, cartilage and skin. Indeed, HA is capable of forming hydrogels, polymer crosslinked networks that are very hygroscopic. Based on these considerations, we propose an overview of HA-based scaffolds developed for brain cancer treatment, central and peripheral nervous systems, discuss their relevance and identify the most successful developed systems.

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Section: Ha-based Specific Device For Various Applicationsmentioning

confidence: 99%

Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders

Djoudi

Molina-Peña²,

Ferreira³

et al. 2022

IJMS

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“…It has been demonstrated that polymeric nanoparticles have the advantages of high stability and mass production [ 22 ]. Natural polymers used in the pharmaceutical industry include dextrose, chitosan, gelatin, collagen, heparin, and albumin [ 23 ]. On the other hand, synthetic polymers such as polyethylene glycol, polylactic acid, poly(lactic-co-glycolic acid), and poly(caprolactone) can also be used in drug delivery [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Smart Polymeric Nanoparticles in Cancer Immunotherapy

Shen

et al. 2023

Pharmaceutics

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Cancer develops with unexpected mutations and causes death in many patients. Among the different cancer treatment strategies, immunotherapy is promising with the benefits of high specificity and accuracy, as well as modulating immune responses. Nanomaterials can be used to formulate drug delivery carriers for targeted cancer therapy. Polymeric nanoparticles used in the clinic are biocompatible and have excellent stability. They have the potential to improve therapeutic effects while significantly reducing off-target toxicity. This review classifies smart drug delivery systems based on their components. Synthetic smart polymers used in the pharmaceutical industry, including enzyme-responsive, pH-responsive, and redox-responsive polymers, are discussed. Natural polymers derived from plants, animals, microbes, and marine organisms can also be used to construct stimuli-responsive delivery systems with excellent biocompatibility, low toxicity, and biodegradability. The applications of smart or stimuli-responsive polymers in cancer immunotherapies are discussed in this systemic review. We summarize different delivery strategies and mechanisms that can be used in cancer immunotherapy and give examples of each case.

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“…In the pharmaceutical industry, plants and plant products are continually used as sources of drugs and excipients. In particular, plant-derived polymers have contributed significant roles in drug delivery systems where they function as excipients [1]. Excipients refer to the non-pharmacological ingredients that are required to convert the Active Pharmaceutical Ingredient (API) into a dosage form.…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Applications of Pectin

Akin-Ajani¹,

Okunlola²

2022

Pectins - The New-Old Polysaccharides

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Pectin, a natural ionic polysaccharide found in the cell wall of terrestrial plants undergoes chain–chain association to form hydrogels upon addition of divalent cations. Based on its degree of esterification, pectin has been classified into two main types. The high methoxyl pectin with a degree of esterification greater than 50%, which is mainly used for its thickening and gelling properties and the low methoxyl pectin, which is widely used for its low sugar-content in jams, both applications being in the food industry. Pectin is mostly derived from citrus fruit peels, but can also be found in other plants such as waterleaf leaves, cocoa husk, and potato pulps. Pectin has been used as an excipient in pharmaceutical formulations for various functions. This chapter will focus on the various applications to which pectin has been used in the pharmaceutical industry.

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Pharmaceutical Applications of Natural Polymers

Cited by 9 publications

References 203 publications

Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders

Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders

Smart Polymeric Nanoparticles in Cancer Immunotherapy

Pharmaceutical Applications of Pectin

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