Ocular Risk Factors for Exudative AMD: A Novel Semiautomated Grading System

Marques, João Pedro; Costa, Miguel; Melo, Pedro; Oliveira, Carlos Manta; Pires, Isabel; Cachulo, Maria Luz; Figueira, João; Silva, Rufino

doi:10.1155/2013/464218

Cited by 15 publications

(21 citation statements)

References 32 publications

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“…Also of note is the fact that in this study we used software to quantify the ocular fundus lesions and to standardize the grading process (Retmarker AMD Research software) [33]. This software incorporates the International Classification Grading System, thus allowing a comparison with other major AMD European studies, such as the Rotterdam Study [18], the EUREYE Study [19], the Reykjavik Eye Study [21], and the Tromso Eye Study [27].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Age-Related Macular Degeneration in Portugal: The Coimbra Eye Study - Report 1

Cachulo

Lobo²,

Figueira

et al. 2015

Ophthalmologica

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Purpose: To evaluate the age- and gender-specific prevalence of early and late age-related macular degeneration (AMD) in a Portuguese population-based sample. Methods: All patients aged ≥55 years of a Portuguese primary health-care unit were recruited for a cross-sectional population-based study. Responders underwent complete ophthalmological examination and digital fundus imaging. Early and late AMD was defined according to the International Age-Related Macular Epidemiological Study Group Classification, and the adopted staging for AMD was the same as that used in the Rotterdam study. The age- and gender-adjusted prevalence of early and late forms of AMD was calculated. Results: Of the 4,370 eligible subjects, 3,000 underwent study procedures (68.6% response rate) and 2,975 were included in the analysis; they had a mean age of 68.9 ± 8.6 years. The overall prevalence of early and late AMD was 15.53% (95% CI 14.25-16.88) and 0.67% (95% CI 0.41-1.04), respectively. Neovascular AMD (NV-AMD) and geographic atrophy (GA) accounted for 0.44% (95% CI 0.23-0.75) and 0.27% (95% CI 0.12-0.53) of individuals, respectively. The highest prevalence of advanced AMD was among those aged ≥75 years (1.13% for NV-AMD; 0.63% for GA). Conclusions: To our knowledge, this is the first AMD epidemiological study in a Portuguese population. The early forms of the disease had a similar prevalence to that of other large-scale population-based cohorts, but late AMD was less frequent than previously reported.

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Section: Discussionmentioning

confidence: 99%

“…Briefly, the grading process always began by calibration, using the optic disc as a reference, with an adopted diameter of 1.5 mm. Afterwards, it was performed as previously described [33]. The stages of ARM disease were graded based on the features observed.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Age-Related Macular Degeneration in Portugal: The Coimbra Eye Study - Report 1

Cachulo

Lobo²,

Figueira

et al. 2015

Ophthalmologica

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“…The central subfield overlaps with the central macula (fig. 1) [24]. Other areas of RNP were also qualitatively analyzed for classification into ischemic/nonischemic subtypes in the final visit.…”

Section: Methodsmentioning

confidence: 99%

Treatment of Retinal Vein Occlusion with Ranibizumab in Clinical Practice: Longer-Term Results and Predictive Factors of Functional Outcome

et al. 2015

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Purpose: To evaluate long-term results and predictors of efficacy in patients with macular edema due to retinal vein occlusion (RVO) treated with intravitreal ranibizumab in a clinical practice setting. Methods: The clinical records of patients with a minimum follow-up of 3 years were retrospectively analyzed. Sixteen eyes with branch RVO (BRVO) and 16 with central RVO (CRVO) were included. All patients performed cross-sectional evaluation with best-corrected visual acuity (BCVA), spectral domain optical coherence tomography and fluorescein angiography. The foveal avascular zone (FAZ) was assessed and microstructural morphology of the retina was characterized. Results: Follow- up was 42.9 ± 9.0 and 44.8 ± 8.0 months in the CRVO and BRVO groups, respectively. Patients with CRVO received on average 6.9 injections, with a final VA gain of 8.3 ± 15.0 letters (p = 0.05). BRVO eyes had on average 5.9 injections, with a final VA gain of 1.6 ± 21.0 letters (p > 0.05). The FAZ area remained stable in both groups (p > 0.05). Baseline BCVA and disruption of the retinal pigment epithelium (RPE) were predictors of final BCVA (p = 0.001 and 0.011, respectively). Conclusion: Although functional outcomes were inferior to those reported in clinical trials, ranibizumab was satisfactory in the long-term treatment of macular edema secondary to RVO and was not associated with increased macular ischemia. Final BCVA depends on baseline BCVA and RPE integrity.

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“…The differential grading was supported by software developed to visualize digital color fundus photographs and to grade AMD retinal lesions – RetmarkerAMD Research (Retmarker SA, Coimbra, Portugal). This platform was developed to assist manual grading of lesions, according to the International Age-Related Macular Epidemiological Study Group Classification [24], and automatically calculates the number of lesions, their size, area and location, as previously described by our group [26]. …”

Section: Methodsmentioning

confidence: 99%

Incidence of Age-Related Macular Degeneration in the Central Region of Portugal: The Coimbra Eye Study – Report 5

et al. 2019

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Purpose: To describe the 6.5-year incidence and progression of age-related macular degeneration (AMD) in a coastal town of central Portugal. Methods: Population-based cohort study. Participants underwent standardized interviews and ophthalmological examination. Color fundus photographs were graded according to the International Classification and Grading System for AMD and ARM. The crude and age-standardized incidence of early and late AMD was calculated, and progression was analyzed. Results: The 6.5-year cumulative incidence of early AMD was 10.7%, and of late AMD it was 0.8%. The incidence of early AMD was 7.2, 13.1 and 17.7% for participants aged 55–64, 65–74 and 75–84 years (p < 0.001). The late AMD incidence was 0.3, 0.9 and 2.8% for the corresponding age groups (p = 0.003). The age-standardized incidence was 10.8% (95% CI, 10.74–10.80%) for early and 1.0% (95% CI, 1.00–1.02%) for late AMD. The incidence of both neovascular AMD and geographic atrophy was 0.4%. Progression occurred in 17.2% of patients. Conclusion: The early AMD incidence in a coastal town of central Portugal was found to be similar to that of major epidemiological studies of European-descent populations; however, the incidence of late AMD was lower, and further analysis on risk factors will be conducted.

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Ocular Risk Factors for Exudative AMD: A Novel Semiautomated Grading System

Cited by 15 publications

References 32 publications

Prevalence of Age-Related Macular Degeneration in Portugal: The Coimbra Eye Study - Report 1

Prevalence of Age-Related Macular Degeneration in Portugal: The Coimbra Eye Study - Report 1

Treatment of Retinal Vein Occlusion with Ranibizumab in Clinical Practice: Longer-Term Results and Predictive Factors of Functional Outcome

Incidence of Age-Related Macular Degeneration in the Central Region of Portugal: The Coimbra Eye Study – Report 5

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