Decreased copper and zinc in sera of Chinese vitiligo patients: A meta‐analysis

Zeng, Qinghai; Yin, Jun; Fan, Fan; Chen, Jing; Chen, Zuo; Xiang, Yuan; Tan, Lirong; Huang, Jinhua; Xiao, Rong

doi:10.1111/1346-8138.12392

Cited by 35 publications

(36 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The levels of serum Zn were also significantly lower in vitiligo patients than in healthy controls ( p < 0.00001). These results demonstrated that decreased levels of serum Cu and Zn are generally present in vitiligo patients [27]. …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the serum zinc level in patients with vitiligo

Mogaddam

Ardabili

Maleki

et al. 2017

pdia

View full text Add to dashboard Cite

IntroductionVitiligo is an acquired, idiopathic disorder characterized by circumscribed depigmented macules and patches, which affects approximately 0.1–2% of the general population worldwide. Zinc is an essential trace element that is necessary for growth and development at all stages of life. Some studies have reported an association between serum zinc levels and vitiligo.AimTo measure the serum zinc level in patients with vitiligo compared to healthy subjects.Material and methodsOne hundred patients with vitiligo and 100 healthy controls were referred to our clinic. The two groups were matched for age and sex. Atomic absorption spectrophotometry was used to measure serum zinc levels. The statistical analysis was performed using SPSS software.ResultsThe mean serum level of zinc in vitiligo patients and controls was 80.11 ±17.10 μg/dl and 96.10 ±16.16 μg/dl, respectively. The serum zinc level in patients with vitiligo was significantly lower than in healthy controls (p = 0.0001).ConclusionsThe results of our study revealed a significant association between vitiligo and serum zinc levels. A relative decrease in the serum zinc level in vitiligo patients can highlight the role of zinc in the pathogenesis of vitiligo, and large-scale studies need to be conducted to confirm these findings and assess the effect of oral zinc supplements in patients with low zinc levels.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In 2014, Zeng et al [27] conducted a meta-analysis to compare the serum levels of Cu and Zn between vitiligo patients and healthy controls. In this meta-analysis, 16 studies with a total of 891 vitiligo cases and 1682 healthy controls were conducted.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the serum zinc level in patients with vitiligo

Mogaddam

Ardabili

Maleki

et al. 2017

pdia

View full text Add to dashboard Cite

show abstract

“…Until now, a few controlled studies about the serum levels of zinc in AD have revealed contradictory results; some authors reported that it is lower [5, 6], whereas others demonstrated no differences [7, 8]. The same controversial result applies to the serum Zn level in other skin diseases like psoriasis and vitiligo [13, 14]. …”

Section: Discussionmentioning

confidence: 99%

Erythrocyte zinc level in patients with atopic dermatitis and its relation to SCORAD index

Karabacak

Aydın

Kutlu

et al. 2016

pdia

View full text Add to dashboard Cite

IntroductionAtopic dermatitis (AD) is a chronic, pruritic inflammatory disease, characterized by a relapsing-remitting course. The pathogenesis of atopic dermatitis is not completely understood, although the disorder appears to result from the complex interaction between immune abnormalities, genetic and environmental factors. Trace elements are essential for normal functioning of the immune system.AimTo determine zinc levels in serum and erythrocytes of patients with AD using an atomic absorption spectrometric technique and to investigate the relationship between those levels and disease activity.Material and methodsSixty-seven patients and 49 controls were enrolled into the study. The disease severity of AD patients was determined according to the Scoring Atopic Dermatitis (SCORAD) index. We measured zinc levels in serum and erythrocytes by the atomic absorption spectrophotometric technique.ResultsErythrocyte zinc levels were significantly lower in AD patients than in the control group (p < 0.001), whereas serum zinc levels did not differ between the groups (p = 0.148). In the AD patient group there was a negative correlation between the SCORAD score and erythrocyte zinc levels (r = –0.791; p < 0.001).ConclusionsThe negative relationship between disease severity and erythrocyte zinc levels might suggest an immunopathological link between AD progression and intracellular zinc metabolism.

show abstract

“…A meta-analysis of Chinese vitiligo patients by Zeng et al further explored the relationship between both Zn and Cu levels in this population of patients. Serum Cu and Zn were compared between the control and vitiligo patients, with vitiligo patients having significantly lower serum levels of both Cu and Zn compared to controls [34]. Although both of these studies indicate some relationship between serum Zn levels and vitiligo, other findings have determined no significant difference between Zn levels in vitiligo patients compared to controls, leaving this topic controversial [37].…”

Section: Minerals: Zinc and Coppermentioning

confidence: 99%

“…Copper is also considered an antioxidant, as it acts as a coenzyme with antioxidant properties. Both Zn and Cu may also be involved in melanogenesis through the catalysis of eumelanin production [34]. Zinc may further contribute, as deficiencies in the Zn-α2-Glycoprotein (ZAG) have been reported in people with vitiligo.…”

Section: Minerals: Zinc and Coppermentioning

confidence: 99%

Assessment of Dietary Supplementation in the Treatment of Vitiligo

Smith¹,

Mohammad²,

Hamzavi³

2017

TODJ

View full text Add to dashboard Cite

Background:Vitiligo is the most common acquired pigmentary disorder in the world. Due to alterations in physical appearance, vitiligo is a psychologically devastating disease. Although treatment options exist, a cure for this disease has yet to be discovered. Of recent interest in vitiligo is the relationship between diet and disease. Objective:To review various dietary modifications and supplementation used in the management of vitiligo. Materials and Methods:A thorough evaluation of recent literature using the keywords "vitiligo, diet, supplement, antioxidant, vitamin, mineral, zinc, copper, gluten-free, celiac disease, alternative medicine" in the NCBI PubMed search function was performed. Results:A total of 39 relevant articles were reviewed and critically evaluated. Conclusion:Initial studies regarding the treatment of vitiligo through dietary modification are promising, although further studies are needed in multiple populations to explore the therapeutic value of these interventions.

show abstract

Decreased copper and zinc in sera of Chinese vitiligo patients: A meta‐analysis

Cited by 35 publications

References 20 publications

Evaluation of the serum zinc level in patients with vitiligo

Evaluation of the serum zinc level in patients with vitiligo

Erythrocyte zinc level in patients with atopic dermatitis and its relation to SCORAD index

Assessment of Dietary Supplementation in the Treatment of Vitiligo

Contact Info

Product

Resources

About