Evaluation of the serum zinc level in patients with vitiligo

Mogaddam, Majid Rostami; Ardabili, Nastaran Safavi; Maleki, Nasrollah; Chinifroush, Mir Mehdi; Fard, Elham Maleki

doi:10.5114/ada.2017.67073

Cited by 15 publications

(28 citation statements)

References 25 publications

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“…Rostami Moghaddam and colleagues (13) reported lower zinc levels in patients with vitiligo. Mirnezami and Rahimi (5) also reported low serum zinc levels in generalized patients with vitiligo.…”

Section: Discussionmentioning

confidence: 98%

“…It is plausible that the deficiency of both vitamin D and zinc levels due to their role in monogenesis, can affect disease progression and severity. However, different studies have reported conflicting results regarding the vitamin D and zinc levels in these patients (4)(5)(6)(13)(14)(15). Also, the association between vitiligo and thyroid disease is not well understood.…”

Section: Introductionmentioning

confidence: 99%

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Zinc, vitamin D and TSH levels in vitiligo patients

Saniee¹

2019

Erciyes Med J

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Objective: Vitiligo is an acquired depigmenting autoimmune disorder of the skin. The disease association with autoimmune diseases, such as thyroid diseases, has been reported. Previous studies among patients with vitiligo have suggested possible correlation between zinc and vitamin D levels with conflicting results. Here we compared the thyroid hormones, zinc, and vitamin D levels in patients with vitiligo with normal healthy subjects. Materials and Methods: We recruited 98 patients with vitiligo and 98 age-and sex-matched healthy subjects visiting dermatology clinics during spring and summer 2017. Serum zinc and vitamin D levels as well as thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (anti-TPO) were measured and compared between groups. Results: Patients with vitiligo had significantly lower zinc (p=0.01) and higher anti-TPO levels (p=0.02) with no difference in vitamin D (p=0.73) and TSH levels (p=0.31). Patients with vitiligo had also significantly higher rate of increased TSH (p=0.02) and positive anti-TPO (p=0.01). We observed no significant correlation between serum levels of vitamin D, zinc, and TSH with age, gender, and disease duration in patients with vitiligo. Conclusion: Patients with vitiligo, compared to healthy subjects, had lower serum zinc levels, but not vitamin D levels. Increased TSH levels were higher in patients with vitiligo with non-significantly higher anti-TPO AB as suggested to be related to autoimmune disease.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Zinc, vitamin D and TSH levels in vitiligo patients

Saniee¹

2019

Erciyes Med J

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“…7 Moreover, our results were consistent with a number of recent studies showing a significant decrease in zinc levels of vitiligo patients compared to healthy controls. [8][9][10] On the contrary some results refuted this relation and established no significant difference in serum zinc levels between vitiligo patients and healthy controls. 11 One study found zinc serum levels to be statistically higher in patients when compared to controls while another study found zinc serum levels insignificantly higher in patients compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic implications of assessment of serum zinc levels in patients with vitiligo: A patient controlled prospective study

Zaki

Nada

Elshahed

et al. 2020

Dermatologic Therapy

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Vitiligo is an autoimmune disease characterized by patches of depigmentation. Zinc is an antiapoptotic molecule that exhibits antioxidant properties. The study aimed to investigate the serum levels of zinc in vitiligo patients compared to healthy controls and to whether exists a correlation between disease severity and serum levels of zinc. Fifty patients with vitilgo (group A) and 50 age and sex matched healthy controls (group B) were recruited and serum zinc level was measured using atomic absorption spectrophotometry and results were compared and correlated to each other and to disease severity and extension. The mean serum zinc levels in group A was 50.93 ± 11.02 in comparison to a mean of 77.09 ± 12.16 in group B (P = .049, T = −1.993). Vitiligo area severity index (VASI) scores in the vitiligo group ranged from 0.5 to 27 with a mean ± SD of (9.19 ± 4.47). A high statistically significant negative correlation was demonstrated between serum zinc levels and the extension of vitiligo (P value = .0001 and R value = − 0.835). A significant association exists between vitiligo and serum zinc levels. Serum zinc levels correlated negatively with vitiligo disease severity and extension. Zinc supplementation and use can be of potential importance in setting vitiligo treatment protocols.

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“…Obtained serum samples were stored at -80 °C until use. For determination of Zn and Cu levels in serum, samples were diluted 10 times with ultrapure water without preliminary preparation and read against a standard chart using the method mentioned above, according to Mogaddam et al [5] and Michalska-Mosiej et al [6]. Each serum sample was measured at least 3 times.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the levels of trace elements in the blood and hair of patients with seborrheic dermatitis

Nazik¹,

Bengü²,

Gül³

et al. 2019

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Background: Seborrheic dermatitis is a chronic inflammatory disease. Structure and amount of lipids in skin, immunological reaction against Malassezia, lipase activity, genetics, environmental factors and stress contribute to the development of the disease, but the pathogenesis is not known precisely. Trace elements play a role in many important functions of organisms. However, the effects of trace elements on skin and adnexal structures are not fully understood. In this study, we aimed to determine the serum zinc, copper, and iron levels as well as the hair zinc, copper, iron, and manganese levels in patients with seborrheic dermatitis and to reveal the relationship between these parameters and seborrheic dermatitis. Materials and methods: 35 female patients with seborrheic dermatitis, aged over 18 years, and 34 healthy females with no known dermatologic or systemic diseases at similar ages were included in the study. Groups were compared in terms of serum and hair trace element levels. Results: When the serum samples of the groups were compared in terms of trace element levels, copper was statistically significantly higher in the seborrheic dermatitis group, but there was no statistically significant difference between zinc and iron levels. Zinc, copper, iron, and manganese levels in the hair samples of the seborrheic dermatitis group were significantly higher than in the control group. Conclusion: Results have shown that trace elements can contribute to the pathophysiology of seborrheic dermatitis. Malassezia colonization seen in seborrheic dermatitis, irritation, and inflammation may affect the passage and distribution of trace elements.

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Evaluation of the serum zinc level in patients with vitiligo

Cited by 15 publications

References 25 publications

Zinc, vitamin D and TSH levels in vitiligo patients

Zinc, vitamin D and TSH levels in vitiligo patients

Therapeutic implications of assessment of serum zinc levels in patients with vitiligo: A patient controlled prospective study

Evaluation of the levels of trace elements in the blood and hair of patients with seborrheic dermatitis

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