CD157 at the intersection between leukocyte trafficking and epithelial ovarian cancer invasion

Abstract

CD157 is a member of the ADP-ribosyl cyclase gene family that is involved in the metabolism of NAD. CD157 behaves both as an ectoenzyme and as a receptor. Though CD157 is anchored to the membrane by a glycosylphosphatidylinositol moiety, which makes it unsuitable to transduce signals on its own, it exploits its localization in selected membrane microdomains and its proclivity to interact with integrins to accomplish receptor functions. Initially characterized as a stromal and myeloid antigen involved in the control of leukocyte adhesion, migration and diapedesis, CD157 was subsequently found to have a far wider distribution. In particular, CD157 was found to be expressed by epithelial ovarian cancer cells where it is involved in interactions among tumor cells, extracellular matrix proteins and mesothelium. The overall picture inferred from experimental and clinical observations is that CD157 is a critical player both in leukocyte trafficking and in ovarian cancer invasion and metastasis formation. In this review, we will discuss the biological mechanisms underpinning the role of CD157 in the control of leukocyte migration and ovarian cancer dissemination.

Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease

“…It is of interest to test if these behavioral impairments in CD157 −/− mice likely reflect impairment of the amygdala (Harding et al, 2002; Surdhar et al, 2012). However, there is no direct evidence that CD157 plays a role in neuronal migration during neurogenesis, although CD157 binds integrins in human monocytes (Lo Buono et al, 2011, 2014) and plays a role in neutrophil migration (Quarona et al, 2013). Our preliminary results show that CD157 is expressed in nestin-positive neural stem cells near the brain ventricular zone.…”

“…CD157 plays a variety of roles in humoral immune responses, neutrophil transmigration and haematopoietic stem cell support (Ishihara and Hirano, 2000; Funaro et al, 2004; Podestà et al, 2005; Malavasi et al, 2006; Mouchiroud et al, 2013). CD157 is also involved in the pathophysiology of various diseases, such as the survival of B cells in rheumatoid arthritis, the progression of leukaemia and metastasis of human ovarian carcinoma cells (Kaisho et al, 1994; Shimaoka et al, 1998; Ishihara and Hirano, 2000; Ortolan et al, 2010; Quarona et al, 2013; Lo Buono et al, 2014). In addition, a new role for CD157 has been reported in stem cells: CD157 induces the catalysis of cyclic ADP-ribose in paneth cells, which promotes intestinal stem cell self-renewal in mice on a calorie-restricted diet (Yilmaz et al, 2012); or lung stem/progenitor cells express CD157 (Wu et al, 2013).…”

Selegiline Ameliorates Depression-Like Behavior in Mice Lacking the CD157/BST1 Gene, a Risk Factor for Parkinson’s Disease

“…CD157/BST-1 has a variety of roles in the humoral immune response, neutrophil transmigration and hematopoietic stem cell support (Ishihara and Hirano, 2000; Funaro et al, 2004; Podestà et al, 2005; Malavasi et al, 2006; Mouchiroud et al, 2013). CD157/BST-1 is also involved in the pathogenesis of several diseases such as survival of B lymphocytes in rheumatoid arthritis, progression of leukemia, and metastasis of human ovarian carcinoma cells (Kaisho et al, 1994; Shimaoka et al, 1998; Ishihara and Hirano, 2000; Ortolan et al, 2010; Quarona et al, 2013; Lo Buono et al, 2014). Recently, genome-wide association studies and meta-analyses for PD identified intronic single-nucleotide polymorphisms (SNPs) in the CD157/BST1 gene on the human chromosome 4p15 as a new susceptibility locus in Asian and European populations (Satake et al, 2009; Tan et al, 2010; Liu et al, 2011, 2013b; International Parkinson Disease Genomics Consortium et al, 2011; Saad et al, 2011; Simón-Sánchez et al, 2011; UK Parkinson’s Disease Consortium et al, 2011; Zimprich, 2011; Lill et al, 2012; Sharma et al, 2012).…”

Communication Impairment in Ultrasonic Vocal Repertoire during the Suckling Period of Cd157 Knockout Mice: Transient Improvement by Oxytocin

“…BST-1 was first isolated from bone marrow stromal cell lines (Kaisho et al, 1994), and BST1 was identified as CD157 by gene cloning (Itoh et al, 1994). Interestingly, despite the important role of CD157 in the immune system (Shimaoka et al, 1998; Lo Buono, 2014), the CD157/BST1 gene was identified as a risk-factor for neurodegeneration, particularly for Parkinson's disease (PD), or at least one of a variety of PD symptoms (Satake et al, 2009; Simón-Sánchez et al, 2011; Sharma et al, 2012; Zhu et al, 2012; Liu et al, 2013b). In addition, a new role for CD157 has been reported in stem cells, which is that CD157 induces the catalysis of cyclic ADP-ribose in paneth cells, which promotes intestinal stem cell self-renewal in mice that are on a calorie-restricted diet (Yilmaz et al, 2012), and cyclic ADP-ribose/CD157 promotes the proliferation of lung stem/progenitor cells (Wu et al, 2013).…”