Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease

Lopatina, Olga; Yoshihara, Toshio; Nishimura, Tomoko; Zhong, Jing; Akther, Shirin; Fakhrul, Azam A. K. M.; Liang, Mingkun; Higashida, Chiharu; Sumi, Kohei; Furuhara, Kazumi; Inahata, Yuki; Huang, J. J.; Koizumi, Keita; Yokoyama, Shigeru; Tsuji, Takahiro; Petugina, Yulia; Sumarokov, Andrei; Салмина, А. Б.; Hashida, Koji; Kitao, Yasuko; Hori, Osamu; Asano, Masahide; Kitamura, Yoshihisa; Kozaka, Takashi; Shiba, Kazuhiro; Zhong, Fangfang; Xie, Min; Sato, Makoto; Ishihara, Katsuhiko; Higashida, Haruhiro

doi:10.3389/fnbeh.2014.00133

Cited by 85 publications

(140 citation statements)

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“…In support of the above observation and as reported previously [42], the brain CD157 mRNA levels decreased markedly 7–14 days postnatally from the relatively high levels in the embryonic period (shown in Fig. 3a ( n = 5 mice)).…”

Section: Resultssupporting

confidence: 92%

“…One hundred percent refers to values on postnatal days 1 or 14 for CD157 and CD38 , respectively. Data for CD157 and CD38 were obtained from previous reports by Lopatina et al [42] and Higashida et al [45], respectively ( n = 5 mice for CD157 and n = 4 mice for CD38 ). b Quantitative data obtained by RT-PCR analysis of CD157 and CD38 mRNA expression in four brain regions of adult male mice using β-actin mRNA as an internal control.…”

Section: Resultsmentioning

confidence: 99%

“…Nonetheless, it is worth considering how CD157 contributes to the occurrence of PD or to at least one or a variety of PD symptoms. Previously, we examined the neuronal function of CD157 by analyzing the phenotypes of CD157 deletion mice that would presumably provide insights into the neuronal functions of CD157 [42]. Interestingly, the results obtained indicated no motor dysfunction but social behavioral impairments in CD157 knockout (KO, CD157 − / − ) mice such as apathy-, anxiety-, and depression-like behaviors [42], which are slightly different from the expected phenotypes involving motor dysfunction that are commonly observed in PD.…”

Section: Introductionmentioning

confidence: 99%

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An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator

et al. 2017

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BackgroundRecent rodent and human studies provide evidence in support of the fact that CD157, well known as bone marrow stromal cell antigen-1 (BST-1) and a risk factor in Parkinson’s disease, also meaningfully acts in the brain as a neuroregulator and affects social behaviors. It has been shown that social behaviors are impaired in CD157 knockout mice without severe motor dysfunction and that CD157/BST1 gene single nucleotide polymorphisms are associated with autism spectrum disorder in humans. However, it is still necessary to determine how this molecule contributes to the brain’s physiological and pathophysiological functions.MethodsTo gain fresh insights about the relationship between the presence of CD157 in the brain and its enzymatic activity, and aberrant social behavior, CD157 knockout mice of various ages were tested.ResultsCD157 immunoreactivity colocalized with nestin-positive cells and elements in the ventricular zones in E17 embryos. Brain CD157 mRNA levels were high in neonates but low in adults. Weak but distinct immunoreactivity was detected in several areas in the adult brain, including the amygdala. CD157 has little or no base exchange activity, but some ADP-ribosyl cyclase activity, indicating that CD157 formed cyclic ADP-ribose but much less nicotinic acid adenine dinucleotide phosphate, with both mobilizing Ca2+ from intracellular Ca2+ pools. Social avoidance in CD157 knockout mice was rescued by a single intraperitoneal injection of oxytocin.ConclusionsCD157 may play a role in the embryonic and adult nervous systems. The functional features of CD157 can be explained in part through the production of cyclic ADP-ribose rather than nicotinic acid adenine dinucleotide phosphate. Further experiments are required to elucidate how the embryonic expression of CD157 in neural stem cells contributes to behaviors in adults or to psychiatric symptoms.Electronic supplementary materialThe online version of this article (doi:10.1186/s12868-017-0350-7) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator

et al. 2017

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“…Since CD157 is a marker of stem cell both in human [25] and mouse [26, 27], the hypothesis that CD157 serves as a point of convergence in conferring mesenchymal and stem-like differentiation to mesothelioma cells is intriguing and deserve further investigation.…”

Section: Discussionmentioning

confidence: 99%

CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome

et al. 2014

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Malignant mesothelioma is a deadly tumor whose diagnosis and treatment remain very challenging. There is an urgent need to advance our understanding of mesothelioma biology and to identify new molecular markers for improving management of patients. CD157 is a membrane glycoprotein linked to ovarian cancer progression and mesenchymal differentiation. The common embryonic origin of ovarian epithelial cells and mesothelial cells and the evident similarities between ovarian and mesothelial cancer prompted us to investigate the biological role and clinical significance of CD157 in malignant pleural mesothelioma (MPM).CD157 mRNA and protein were detected in four of nine MPM cell lines of diverse histotype and in 85.2% of MPM surgical tissue samples (32/37 epithelioid; 37/44 biphasic). CD157 expression correlated with clinical aggressiveness in biphasic MPM. Indeed, high CD157 was a negative prognostic factor and an independent predictor of poor survival for patients with biphasic MPM by multivariate survival analysis (HR = 2.433, 95% CI 1.120-5.284; p = 0.025). In mesothelioma cell lines, CD157 gain (in CD157-negative cells) or knockdown (in CD157-positive cells) affected cell growth, migration, invasion and tumorigenicity, most notably in biphasic MPM cell lines. In these cells, CD157 expression was associated with increased activation of the mTOR signaling pathway, resulting in decreased platinum sensitivity. Moreover, a trend towards reduced survival was observed in patients with biphasic MPM receiving postoperative platinum-based chemotherapy. These findings indicate that CD157 is implicated in multiple aspects of MPM progression and suggest that CD157 expression could be used to stratify patients into different prognostic groups or to select patients that might benefit from particular chemotherapeutic approach.

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“…The images were obtained using an Olympus IX71 inverted microscope equipped with a cooled CCD camera (Cool SNAP HQ2; Roper Scientific, Tucson, AZ, USA). The number of c-Fos immuno-positive nuclei in each brain section was recorded and analyzed using Metamorph software (Molecular Devices, Downingtown, PA, USA), as described previously [31,32]. Only the c-Fos-positive nuclei within a specific size range were counted and a constant threshold level of staining was used to distinguish c-Fos-positive cells as follows: a fluorescence diameter < 13.5 μm and intensity above 445.6 (arbitrary units) were counted.…”

Section: Methodsmentioning

confidence: 99%

c-Fos expression in the paternal mouse brain induced by communicative interaction with maternal mates

et al. 2014

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BackgroundAppropriate parental care by fathers greatly facilitates health in human family life. Much less is known from animal studies regarding the factors and neural circuitry that affect paternal behavior compared with those affecting maternal behavior. We recently reported that ICR mouse sires displayed maternal-like retrieval behavior when they were separated from pups and caged with their mates (co-housing) because the sires receive communicative interactions via ultrasonic and pheromone signals from the dams. We investigated the brain structures involved in regulating this activity by quantifying c-Fos-immunoreactive cells as neuronal activation markers in the neural pathway of male parental behavior.Resultsc-Fos expression in the medial preoptic area (mPOA) was significantly higher in sires that exhibited retrieval behavior (retrievers) than those with no such behavior (non-retrievers). Identical increased expression was found in the mPOA region in the retrievers stimulated by ultrasonic vocalizations or pheromones from their mates. Such increases in expression were not observed in the ventral tegmental area (VTA), nucleus accumbens (NAcc) or ventral palladium (VP). On the following day that we identified the families of the retrievers or non-retrievers, c-Fos expression in neuronal subsets in the mPOA, VTA, NAcc and VP was much higher in the retriever sires when they isolated together with their mates in new cages. This difference was not observed in the singly isolated retriever sires in new cages. The non-retriever sires did not display expression changes in the four brain regions that were assessed.ConclusionThe mPOA neurons appeared to be activated by direct communicative interactions with mate dams, including ultrasonic vocalizations and pheromones. The mPOA-VTA-NAcc-VP neural circuit appears to be involved in paternal retrieval behavior.

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Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease

Cited by 85 publications

References 99 publications

An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator

An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator

CD157 enhances malignant pleural mesothelioma aggressiveness and predicts poor clinical outcome

c-Fos expression in the paternal mouse brain induced by communicative interaction with maternal mates

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