Thalidomide prolongs survival after experimental musculoskeletal injury, through an effect on mononuclear apoptosis

Panousis, Konstantinos P.; Nikolaou, Vassilios S.; Τσαγανός, Θωμάς; Lallos, Stergios N.; Giamarellos‐Bourboulis, Evangelos J.; Efstathopoulos, Nicolas

doi:10.1016/j.jss.2013.11.1104

Cited by 3 publications

(2 citation statements)

References 37 publications

(34 reference statements)

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“…[23] Thalidomide is known to inhibit TNF-α through expedited degradation of messenger RNA. [24] Our study was coherent with above studies that found increased TNF-α levels. At the same time, it was observed that both etanercept and thalidomide treatment was convenient in decreasing TNF-α levels.…”

Section: Discussionsupporting

confidence: 93%

The Therapeutic Effects of Thalidomide and Etanercept on Septic Rats Exposed to Lipopolysaccharide

İlhan

Susam

Gül

2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:The aim of this study was to evaluate the therapeutic effects of thalidomide and etanercept on lipopolysaccharide (LPS)-induced sepsis in a rat model. METHODS:Thirty male Wistar Albino rats were divided into 5 groups: Control, LPS, LPS+Thalidomide, LPS+Etanercept, and LPS+Thalidomide+Etanercept. The control group was given a 1 mL intraperitoneal (i.p.) injection of 0.9% saline solution. For endotoxic treatment, the rats were injected with a single i.p. dose of LPS (Escherichia coli 0111:B4 (5 mg/kg). Thalidomide (0.5 mg/ kg) and etanercept (1 mg/kg) were administered i.p. to the therapeutic groups. Hepatic tissue tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and platelet-derived growth factor (PDGF) levels were determined by enzyme-linked immunosorbent assay and malondialdehyde (MDA) levels and total oxidant status (TOS) were measured using appropriate methods. RESULTS:In vivo results exhibited elevated liver tissue TNF-α, IL-6, ICAM-1, PDGF, MDA, and TOS levels in the LPS-treated animals compared with the controls. The analysis of liver tissue supported the findings of biochemical alterations and indicated a therapeutic role for thalidomide and etanercept. Treatment of septic animals with these agents resulted in a remarkable decrease in the selected proinflammatory cytokines, angiogenic factors, and reactive oxygen parameters. CONCLUSION:Restoration of cytokine balance and oxidant status to normal levels following treatment with selected therapeutic agents suggests that thalidomide and etanercept can help to avoid the potentially devastating effects of sepsis.

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Section: Discussionsupporting

confidence: 93%

The Therapeutic Effects of Thalidomide and Etanercept on Septic Rats Exposed to Lipopolysaccharide

İlhan

Susam

Gül

2018

Ulus Travma Acil Cerrahi Derg

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“…In the study by Panousis evaluating thalidomide effect on musculoskeletal injury in an experimental model, thalidomide prolonged the survival of experimental models with musculoskeletal injury by preventing mononuclear apoptosis. Therefore, thalidomide can be used for management of severe traumas [12]. Thalidomide has several adverse effect on the patients with multiple myeloma, but the most common complication is toxic neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Avascular Necrosis of Humeral Head after Thalidomide Use: A Report of Two Cases

Rezaeian

2018

OPROJ

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Radiographic evaluation: Standard radiological diagnoses include conventional x-ray images. True anterior-posterior (AP) view (Figure 1) showed subchondral sclerosis and a radiolucent Abstract Background: Thalidomide is an immunomodulatory drug which is used for treatment of certain cancers such as multiple myeloma. Multiple myeloma (MM) is a cancer that creates a specific type of white blood cell called plasma cell and accumulates these cancerous cells in bone marrow. To our knowledge, there is no report of avascular necrosis of humeral head after thalidomide use; hence, the aim of present study was to report two cases of avascular necrosis of humeral head after thalidomide use in MM patients.

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Apoptosis of T Cells and Monocytes

Kucharzik¹

2015

Frontiers of Gastrointestinal Research

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Thalidomide prolongs survival after experimental musculoskeletal injury, through an effect on mononuclear apoptosis

Cited by 3 publications

References 37 publications

The Therapeutic Effects of Thalidomide and Etanercept on Septic Rats Exposed to Lipopolysaccharide

The Therapeutic Effects of Thalidomide and Etanercept on Septic Rats Exposed to Lipopolysaccharide

Avascular Necrosis of Humeral Head after Thalidomide Use: A Report of Two Cases

Apoptosis of T Cells and Monocytes

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