Objective Hyposmia is a sensorial disorder in which patients have a reduced sense of smell. However, there are no effective regimens for the management of this disorder. Therefore, the aim of this study is to evaluate the therapeutic effect of intranasal insulin on olfactory recovery in patients with hyposmia. Study Design This is a double-blinded, randomized controlled trial. Setting Intervention. Subjects and Methods This study was administered on 38 patients with hyposmia according to the inclusion and exclusion criteria. Patients were randomly divided into 2 parallel groups. The intervention and placebo groups underwent endoscopic placement of intranasal insulin gel foam (40 IU) and saline-soaked gel foam into the olfactory cleft, respectively. The procedure was performed twice a week for 4 weeks with butanol threshold testing initially and 4 weeks after treatment. Results The Connecticut Chemosensory Clinical Research Center score in the intervention group was significantly higher compared to that of the placebo group after 4 weeks ( P = .01). Moreover, no adverse effects were reported in both groups. Conclusion Our findings indicated that intranasal insulin (40 IU) administration may trigger the improvement in the olfactory sense and also appears to be free of significant adverse events in this small cohort. However, due to limited research regarding this topic, further studies using a larger population are required.
BackgroundPostoperative pain is one of the most complications in endoscopic sinus surgery. We aimed to evaluate the effect of the sphenopalatine ganglion block (SPGB) with bupivacaine on postoperative pain in patients undergoing endoscopic sinus surgery.Methods and Materials: In this clinical trial, 40 patients who indicated functional endoscopic sinus surgery were selected and then divided into 2 parallel groups as intervention and control. The intervention group was received 1.5 mL of bupivacaine 0.5% (injected to sphenopalatine ganglion) and while control was injected 1.5 mL of normal saline at the same injection site. Also, the visual analogue scale (VAS) was recorded immediately after anesthesia, along with 6, 12, 24, 48 h, 7 days, and 21 days after the operation for all patients.ResultsImmediately after anesthesia, as well as 6, 12, and 24 h after the operation, VAS in the intervention group was significantly lower than in the control group (P < .05, for all). However, there were no significant differences between the 2 groups regarding VAS 48 h as well as 7 and 21 days after surgery (P > .05, for both). Also, the rescue analgesia in the intervention group was significantly lower than in the control group (P = .01).ConclusionSPGB with bupivacaine 0.5% (1.5 mL) was a simple, effective, safe, and noninvasive method for the management of postoperative pain in the patients undergoing endoscopic sinus surgery.
Pregabalin has more effect, safely and usefully than acetaminophen on the management of postoperative pain in the patients with nasal polyposis undergoing functional endoscopic sinus surgery.
BackgroundChronic rhinosinusitis (CRS) is a common inflammatory disease of nasal and
paranasal sinuses, with many treatment methods available for the management
of this disease. Recently, herbal medicines have shown a significant impact
on inflammatory diseases such as CRS, and one of these herbal medicines is
Nigella sativa. Therefore, the current study aimed to
evaluate the effectiveness of N. sativa in patients with
CRS without nasal polyp (CRSsNP).MethodsIn this randomized clinical trial, 65 patients with mild to moderate CRSsNP
were enrolled based on the inclusion criteria. Patients were divided
randomly into 2 parallel groups: intervention and placebo groups. Patients
in the intervention group received 2 puffs/day of N. sativa
nasal spray (1 g/day of N. sativa) and in the placebo group
received 2 puffs/day of sodium chloride spray 0.65%.ResultsThirty-one patients (19 men and 12 women) in the intervention group and 34 in
the placebo group (18 men and 16 women) were evaluated. Lund–McKay, Lund
Kennedy, and Sino-Nasal Outcome Test-22 scores were assessed for both groups
after 8 weeks of treatments. These scores decreased significantly in both
groups. However, these scores were significantly lower in the intervention
group compared with the placebo group (P < .0001, for
all).ConclusionThe use of N. sativa nasal spray has symptom reliever effect
with no adverse effects in patients with CRSsNP.
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