Clinical outcomes of platelet rich plasma (PRP) as an adjunct to microfracture surgery in osteochondral lesions of the talus

Güney, Ahmet; Akar, Mustafa; Karaman, Íbrahím; Oner, Mithat; Güney, Betül

doi:10.1007/s00167-013-2784-5

Cited by 113 publications

(109 citation statements)

References 32 publications

(40 reference statements)

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“…Several trials have reported superior functional outcome and improved histologic scores when comparing PRPenhanced microfracture versus microfracture alone. 10,11 Data regarding outcomes of BioCartilage use in human subjects are limited to expert opinion, but controlled human trials examining outcome differences between standard microfracture and BioCartilage techniques are currently under way. To date, an overall beneficial effect has been observed in more than 1,000 patients implanted with BioCartilage, with no adverse events related to this therapy.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Glenoid Chondral Defect Using Micronized Allogeneic Cartilage Matrix Implantation

Shin

Mellano

Cvetanovich

et al. 2014

Arthroscopy Techniques

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Focal chondral lesions of the glenohumeral joint, though less common than chondral defects in the knee or ankle, can be a significant source of pain in an active population. For patients in whom nonsurgical management fails, promising results have been reported after arthroscopic microfracture surgery to treat such lesions. However, microfracture leads to growth of fibrocartilage tissue and is biomechanically less durable than native hyaline cartilage. Recently, augmentation of the microfractured defect with micronized allogeneic cartilage and platelet-rich plasma has been described to restore hyaline-like cartilage and potentially protect the subchondral bone from postsurgical fracture biology within the base of the defect. We present a simple arthroscopic technique of implanting dehydrated, micronized allogeneic cartilage scaffold to treat an isolated chondral lesion of the glenoid.

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Section: Discussionmentioning

confidence: 99%

Treatment of Glenoid Chondral Defect Using Micronized Allogeneic Cartilage Matrix Implantation

Shin

Mellano

Cvetanovich

et al. 2014

Arthroscopy Techniques

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“…The ability of PRP preparations that mimic a native ECM milieu to recruit host progenitor/stem cells to enhance endogenous regenerative processes has also been proposed for further investigation [55]. In one study, when used as an adjuvant agent in arthroscopic microfracture surgery for the management of osteochondral lesions of the talus, PRP resulted in an improved functional status score in the medium term [606]. Additionally, when used in lumbar spine surgery for patients with posterolateral arthrodesis, a cancellous bone substitute soaked in PRP resulted in an enhanced fusion rate during the first 6 months after surgery and increased bone density, thus joining osteoinductive and osteoconductive effects [607].…”

Section: Formulations Enriched With Endogenous Growth Factorsmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

925

513

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Biomaterials have played an increasingly prominent role in the success of biomedical devices and in the development of tissue engineering, which seeks to unlock the regenerative potential innate to human tissues/organs in a state of deterioration and to restore or reestablish normal bodily function. Advances in our understanding of regenerative biomaterials and their roles in new tissue formation can potentially open a new frontier in the fast-growing field of regenerative medicine. Taking inspiration from the role and multi-component construction of native extracellular matrices (ECMs) for cell accommodation, the synthetic biomaterials produced today routinely incorporate biologically active components to define an artificial in vivo milieu with complex and dynamic interactions that foster and regulate stem cells, similar to the events occurring in a natural cellular microenvironment. The range and degree of biomaterial sophistication have also dramatically increased as more knowledge has accumulated through materials science, matrix biology and tissue engineering. However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production. Utilizing biomaterials of human origin as building blocks for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural tissue with regard to its physical and chemical properties for the orchestration of wound healing and tissue regeneration. In addition to directly using tissue transfers and transplants for repair, new applications of human-derived biomaterials are now focusing on the use of naturally occurring biomacromolecules, decellularized ECM scaffolds and autologous preparations rich in growth factors/non-expanded stem cells to either target acceleration/magnification of the body's own repair capacity or use nature's paradigms to create new tissues for restoration. In particular, there is increasing interest in separating ECMs into simplified functional domains and/or biopolymeric assemblies so that these components/constituents can be discretely exploited and manipulated for the production of bioscaffolds and new biomimetic biomaterials. Here, following an overview of tissue auto-/allo-transplantation, we discuss the recent trends and advances as well as the challenges and future directions in the evolution and application of human-derived biomaterials for reconstructive surgery and tissue engineering. In particular, we focus on an exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications and to provide inspiration for the design of future biomaterials.

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“…In a welldesigned randomized prospective study performed by Guney et al, 23 patients who received microfracture surgery were divided into 2 groups. Sixteen patients received treatment with microfracture surgery alone, whereas the remaining patients (PRP group, n = 19) were also given 1 dose of PRP the day after surgery.…”

Section: Discussionmentioning

confidence: 99%

Clinical Effects of Platelet-Rich Plasma and Hyaluronic Acid as an Additional Therapy for Talar Osteochondral Lesions Treated with Microfracture Surgery

et al. 2015

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Clinical outcomes of platelet rich plasma (PRP) as an adjunct to microfracture surgery in osteochondral lesions of the talus

Abstract: II.

Cited by 113 publications

References 32 publications

Treatment of Glenoid Chondral Defect Using Micronized Allogeneic Cartilage Matrix Implantation

Treatment of Glenoid Chondral Defect Using Micronized Allogeneic Cartilage Matrix Implantation

Advancing biomaterials of human origin for tissue engineering

Clinical Effects of Platelet-Rich Plasma and Hyaluronic Acid as an Additional Therapy for Talar Osteochondral Lesions Treated with Microfracture Surgery

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