Treatment of Glenoid Chondral Defect Using Micronized Allogeneic Cartilage Matrix Implantation

Shin, Jason J.; Mellano, C; Cvetanovich, Gregory L.; Frank, Rachel M.; Cole, Brian J.

doi:10.1016/j.eats.2014.05.014

Cited by 19 publications

(10 citation statements)

References 10 publications

(12 reference statements)

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“…The use of MCM has further been reported on chondral defects of the glenoid, capitellum, and tibial plateau. [21][22][23][24] However, there is limited data to guide the optimal clinical treat-ment protocol for the use of MCM, and additional laboratory studies could further enhance the current technique.…”

Section: Discussionmentioning

confidence: 99%

Effects of Micronized Cartilage Matrix on Cartilage Repair in Osteochondral Lesions of the Talus

et al. 2018

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Background The repair of osteochondral lesions remains a challenge due to its poor vascularity and limited healing potential. Micronized cartilage matrix (MCM) is dehydrated, decellularized, micronized allogeneic cartilage matrix that contains the components of native articular tissue and is hypothesized to serve as a scaffold for the formation of hyaline-like tissue. Our objective was to demonstrate in vitro that the use of MCM combined with mesenchymal stem cells (MSCs) can lead to the formation of hyaline-like cartilage tissue in a single-stage treatment model. Design In group 1 (no wash), 250 µL MCM was reconstituted in 150 µL Dulbecco's phosphate-buffered saline (DPBS) for 5 minutes. Group 2 (saline wash) included 250 µL MCM washed in 20 mL DPBS for 30 minutes, then aspirated to remove all DPBS and reconstituted in 150 µL DPBS. Group 3 (serum wash): 250µL MCM washed in 20 mL DPBS for 30 minutes, then aspirated and reconstituted in 150 µL fetal bovine serum. Each group was then added to 50 µL solution of MSC suspended in DPBS at a concentration of 1.2 × 10 cells/350 µL. After 3 weeks, the defects were extracted and sectioned to perform viability and histologic analyses. Results Stem cells without rehydration of the MCM showed almost no viability whereas near complete cell viability was seen after rehydration with serum or saline solution, ultimately leading to chondrogenic differentiation and adhesion to the MCM particles. Conclusion We have shown in this proof-of-concept in vitro study that MCM can serve as a scaffold for the growth of cartilage tissue for the treatment of osteochondral lesions.

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Section: Discussionmentioning

confidence: 99%

Effects of Micronized Cartilage Matrix on Cartilage Repair in Osteochondral Lesions of the Talus

et al. 2018

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“…Currently, there is no cure for arthrosis, nor for rheumatoid arthritis (RA) or the other three types of arthritis, but some approaches involve invasive practices, such as microfracture procedures 1 , which however cause fibrosis instead of stimulating cartilage growth, autografting (to prevent rejection), and finally chondrocyte or stem cell implantations within the affected site.…”

Section: Artificial Aggrecan Prodrugs In the Treatment Of Arthrosismentioning

confidence: 99%

Artificial Aggrecan prodrugs in the treatment of Arthrosis

Damavandi¹

2021

Preprint

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Arthrosis (OA) is a debilitating disease which increasingly affects the geriatric population. Recent studies have shown that proteoglycan forming cartilage in human tissue is citrullinated in osteoarthritic patients and this could be the cause for the enhanced fragility in the knee joints, leading to fractures and falls. The flexibility of citrulline could be reduced compared to that of arginine as citrulline presents incorporations of rigid nitric elements as well as “condensed” proline atoms, making it resemble a metabolic byproduct of collagen and arginine. In truth, citrulline derives from the activity of multiple enzymes, both aggrecanase and arginase-1. The commentary describes causal involvement of citrullination in OA and also indicates potential therapeutic approaches to how displacing the pathological citrullinated arginine, could help patients with OA.

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“…11 This technique involves securing the allogeneic graft over a microfractured glenoid surface with fibrin glue. Advantages of this technique include an allarthroscopic approach and the ability to accomplish the technique in a single-stage procedure.…”

Section: Discussionmentioning

confidence: 99%

Osteochondral Autograft Transfer Technique for Glenoid Osteochondral Defect

Wyland

Beicker

2016

Arthroscopy Techniques

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Glenoid osteochondral defects can be a significant source of pain and disability in an active population. Many treatments are available, but most joint-preserving procedures are limited to debridement, abrasion chondroplasty, or marrow-stimulation techniques, all of which depend on healthy underlying bone and none of which address underlying bony pathology. Osteochondral autograft transfer has been a successful form of treatment for lesions in the knee, elbow, and ankle, especially when subchondral bone is involved. We describe an arthroscopic method of treating glenoid osteochondral lesions with an osteochondral autograft transfer using a graft from the patient's ipsilateral knee. This technique addresses both cartilage and osseous pathology with minimal morbidity and provides a good biological restorative option for patients with isolated glenoid osteochondral defects.

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Treatment of Glenoid Chondral Defect Using Micronized Allogeneic Cartilage Matrix Implantation

Cited by 19 publications

References 10 publications

Effects of Micronized Cartilage Matrix on Cartilage Repair in Osteochondral Lesions of the Talus

Effects of Micronized Cartilage Matrix on Cartilage Repair in Osteochondral Lesions of the Talus

Artificial Aggrecan prodrugs in the treatment of Arthrosis

Osteochondral Autograft Transfer Technique for Glenoid Osteochondral Defect

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