T2‐weighted prostate MRI at 7 tesla using a simplified external transmit‐receive coil array: Correlation with radical prostatectomy findings in two prostate cancer patients

Rosenkrantz, Andrew B.; Zhang, Bei; Ben‐Eliezer, Noam; Nobin, J. Le; Melamed, Jonathan; Deng, Fang; Taneja, Samir S.; Wiggins, Graham C.

doi:10.1002/jmri.24511

Cited by 25 publications

(19 citation statements)

References 6 publications

(9 reference statements)

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“…However, a 3T vs. 7T comparison with identical coils would favor one of the field strengths, as optimal coil design depends on the field strength. In this study, the 7T coil array was an in‐house developed array that resulted from a gradual evolution of body imaging arrays at 7T . The 3T coil array is a widely used, state‐of‐the‐art commercial coil and it is also the coil array that is used for prostate cancer patients in our department.…”

Section: Discussionmentioning

confidence: 99%

Comparing signal‐to‐noise ratio for prostate imaging at 7T and 3T

Steensma

Luttje

Voogt

et al. 2018

Magnetic Resonance Imaging

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Background In MRI, the signal‐to‐noise ratio (SNR) theoretically increases with B 0 field strength. However, because of attenuation of the radiofrequency (RF) fields at 7T, it is not certain if this SNR gain can be realized for prostate imaging. Purpose/Hypothesis To investigate the SNR gain in prostate imaging at 7T as compared with 3T. It is expected that SNR will improve for prostate imaging at 7T compared with 3T. Study Type Prospective. Subjects Four healthy volunteers and one prostate cancer patient. Field Strength/Sequence All subjects were scanned at 3T and at 7T using optimal coil setups for both field strengths. For all volunteers, proton density‐weighted images were acquired for SNR analysis and actual flip angle imaging (AFI) maps were acquired for correction of measured SNR values. In the patient, a T 2 ‐weighted (T 2 w) image was acquired at 3T and at 7T. Assessment SNR was calculated in the prostate region for all volunteers. SNR was normalized for flip angle, receiver bandwidth, and voxel volume. SNR was also calculated for different sensitivity encoding (SENSE) acceleration factors. Statistical Testing SNR values are represented as the arithmetic mean of SNR values in the prostate. Estimated SNR in the T 2 w image is calculated as the arithmetic mean of the signal intensity (SI) divided by the standard deviation of the SI in a specified zone. Tumor‐to‐tissue contrast is calculated as (SI tumor +SI zone )/( SI tumor ‐SI zone ). Results An increase in SNR ranging from 1.7‐fold to 2.8‐fold was measured in the prostate at 7T in comparison to 3T for four volunteers. At 7T, it is possible to achieve a 4‐fold SENSE acceleration in the left‐right direction with similar SNR to a nonaccelerated 3T image. T 2 w imaging was done at 3T and 7T in one patient, where improved tumor‐to‐tissue contrast was demonstrated at 7T. Data Conclusion SNR improves for prostate imaging at 7T as compared with 3T. Level of Evidence: 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:1446–1455.

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Section: Discussionmentioning

confidence: 99%

Comparing signal‐to‐noise ratio for prostate imaging at 7T and 3T

Steensma

Luttje

Voogt

et al. 2018

Magnetic Resonance Imaging

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“…Some limitations of MRI are that highfieldstrength MRI systems cur rently available are not configured for intraoperative imaging and surgical guidance, and their resolution is still limited to about 200 μm per voxel in plane and 2-3 mm in the z direction. Future trends in imaging of the prostate using MRI include the introduction of magnets with a higher field strength (for example, 7 T and greater) for continued improvement in sensitivity, resolution, and image acquisition times; [91][92][93][94] however, further safety studies are w arranted before increased field strengths should be used. …”

Section: Magnetic Resonance Imagingmentioning

confidence: 99%

Novel methods for mapping the cavernous nerves during radical prostatectomy

Fried

Burnett

2015

Nat Rev Urol

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The cavernous nerves, which course along the surface of the prostate gland, are responsible for erectile function. During radical prostatectomy, urologists are challenged in preserving these nerves and their function. Cavernous nerves are microscopic and show variable location in different patients; therefore, postoperative sexual potency rates are widely variable following radical prostatectomy. A variety of technologies, including electrical and optical nerve stimulation, dye-based optical fluorescence and microscopy, spectroscopy, ultrasound and magnetic resonance imaging have all been used to study cavernous nerve anatomy and physiology, and some of these methods are also potential intraoperative methods for identifying and preserving cavernous nerves. However, all of these technologies have inherent limitations, including slow or inconsistent nerve responses, poor image resolution, shallow image depth, slow image acquisition times and/or safety concerns. New and emerging technologies, as well as multimodal approaches combining existing methods, hold promise for improved postoperative sexual outcomes and patient quality of life following radical prostatectomy.

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“…Rosenkrantz et al demonstrated the feasibility of 7T MRI in 2 patients with biopsy proven prostate cancer. They demonstrated a signal to noise ratio gain of 2.1 at 7T MRI vs 3T MRI and images showed excellent visual correlation with the radical prostatectomy specimens [25]. Several studies demonstrated the safety and feasibility of MR spectrocopic imaging at 7T in patients with biopsy proven prostate cancer.…”

Section: Imaging For Patient Selectionmentioning

confidence: 99%

Imaging modalities in focal therapy

Muller

Bos

Pinto

et al. 2014

Current Opinion in Urology

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Purpose of review Focal therapy for prostate cancer is emerging as a management option between active surveillance and radical treatments. In this article we present two of the most important imaging modalities in focal therapy, multiparametric MRI and Ultrasonography. We review recent advances within these two platforms. Recent findings State-of-the-art imaging in all phases of focal therapy is essential for treatment safety. In patient selection, treatment guidance and follow-up, different aspects of imaging are important. mpMRI is an imaging technology with high imaging resolution and contrast. This makes it an excellent technology for patient selection and treatment planning and follow-up. Ultrasound has the unique property of real time image acquisition. This makes it an excellent technology for real time treatment guidance. There are multiple novelties in these two platforms that have increased the accuracy considerably. Examples in ultrasound are: CEUS, elastography, shear-wave elastography and histoscanning. In mpMRI these advantages consist of multiple sequences combined to one image and MR thermometry. Summary Standardization of mpTRUS and mpMRI is of paramount importance. For targeted treatment and follow-up, a good negative predictive value of the test is important. There is much to gain both of these developing fields and imaging accuracy of the two platforms is comparable. Standardization in conduct and interpretation, 3D reconstruction and fusion of the two platforms can make focal therapy for prostate cancer standard of care.

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T2‐weighted prostate MRI at 7 tesla using a simplified external transmit‐receive coil array: Correlation with radical prostatectomy findings in two prostate cancer patients

Abstract: We have demonstrated feasibility of a simplified external coil array for high-resolution T2-weighted prostate MRI at 7T.

Cited by 25 publications

References 6 publications

Comparing signal‐to‐noise ratio for prostate imaging at 7T and 3T

Comparing signal‐to‐noise ratio for prostate imaging at 7T and 3T

Novel methods for mapping the cavernous nerves during radical prostatectomy

Imaging modalities in focal therapy

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