Novel methods for mapping the cavernous nerves during radical prostatectomy

Fried, Nathaniel M.; Burnett, Arthur L.

doi:10.1038/nrurol.2015.174

Cited by 17 publications

(18 citation statements)

References 104 publications

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“…Among the various noninvasive techniques to achieve deep tissue penetration, ultrasound is widely recognized as an efficient biomedical diagnostic imaging modality in hospitals due to its inherent deep-penetration properties (e.g., < 20 cm) 173, 174. It has been extensively utilized in clinics to provide valuable information of internal body structures such as muscles, tendons, joints, vessels, organs, and practice of examining pregnant women with obstetric ultrasound for prenatal care in recent decades 175, 176.…”

Section: Light-assisted Approaches For Theranosticsmentioning

confidence: 99%

Recent Advances of Light-Mediated Theranostics

Ai¹,

Mu²,

Xing³

2016

Theranostics

185

121

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Currently, precision theranostics have been extensively demanded for the effective treatment of various human diseases. Currently, efficient therapy at the targeted disease areas still remains challenging since most available drug molecules lack of selectivity to the pathological sites. Among different approaches, light-mediated therapeutic strategy has recently emerged as a promising and powerful tool to precisely control the activation of therapeutic reagents and imaging probes in vitro and in vivo, mostly attributed to its unique properties including minimally invasive capability and highly spatiotemporal resolution. Although it has achieved initial success, the conventional strategies for light-mediated theranostics are mostly based on the light with short wavelength (e.g., UV or visible light), which may usually suffer from several undesired drawbacks, such as limited tissue penetration depth, unavoidable light absorption/scattering and potential phototoxicity to healthy tissues, etc. Therefore, a near-infrared (NIR) light-mediated approach on the basis of long-wavelength light (700-1000 nm) irradiation, which displays deep-tissue penetration, minimized photo-damage and low autofluoresence in living systems, has been proposed as an inspiring alternative for precisely phototherapeutic applications in the last decades. Despite numerous NIR light-responsive molecules have been currently proposed for clinical applications, several inherent drawbacks, such as troublesome synthetic procedures, low water solubility and limited accumulation abilities in targeted areas, heavily restrict their applications in deep-tissue therapeutic and imaging studies. Thanks to the amazing properties of several nanomaterials with large extinction coefficient in the NIR region, the construction of NIR light responsive nanoplatforms with multifunctions have become promising approaches for deep-seated diseases diagnosis and therapy. In this review, we summarized various light-triggered theranostic strategies and introduced their great advances in biomedical applications in recent years. Moreover, some other promising light-assisted techniques, such as photoacoustic and Cerenkov radiation, were also systemically discussed. Finally, the potential challenges and future perspectives for light-mediated deep-tissue diagnosis and therapeutics were proposed.

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Section: Light-assisted Approaches For Theranosticsmentioning

confidence: 99%

Recent Advances of Light-Mediated Theranostics

Ai¹,

Mu²,

Xing³

2016

Theranostics

185

121

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“…Figure 2 illustrates the phenomena of changing resolution and tissue penetration depth as a function of US frequency (23). In general, US attenuation is a result of interactions between the US wave and tissue resulting in signal scattering and absorption.…”

Section: Us Physicsmentioning

confidence: 99%

Ultrasound capsule endoscopy: sounding out the future

Cox¹,

Stewart²,

Lay³

et al. 2017

Ann. Transl. Med.

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Video capsule endoscopy (VCE) has been of immense benefit in the diagnosis and management of gastrointestinal (GI) disorders since its introduction in 2001. However, it suffers from a number of well recognized deficiencies. Amongst these is the limited capability of white light imaging, which is restricted to analysis of the mucosal surface. Current capsule endoscopes are dependent on visual manifestation of disease and limited in regards to transmural imaging and detection of deeper pathology. Ultrasound capsule endoscopy (USCE) has the potential to overcome surface only imaging and provide transmural scans of the GI tract. The integration of high frequency microultrasound (µUS) into capsule endoscopy would allow high resolution transmural images and provide a means of both qualitative and quantitative assessment of the bowel wall. Quantitative ultrasound (QUS) can provide data in an objective and measurable manner, potentially reducing lengthy interpretation times by incorporation into an automated diagnostic process.The research described here is focused on the development of USCE and other complementary diagnostic and therapeutic modalities. Presently investigations have entered a preclinical phase with laboratory investigations running concurrently.

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“…The individual CN are a few hundreds of micrometers in diameter and the CNB are even thinner, making it difficult to predict the exact locations and paths of these nerves, due to interpatient variability. 5 Despite the innovation of laparoscopic/robotic RP 6 , post-operative erectile function recovery outcomes have not necessarily improved over time with only approximately 70% resulting in fully restored potency rates at 12 months after surgery. 7 Irrespective of surgical approach, RP demands an improved understanding of the anatomical features of the target tissue, particularly with respect to the functional anatomy of the CN network for its maximal preservation.…”

Section: Introductionmentioning

confidence: 99%

Real-time, functional intra-operative localization of rat cavernous nerve network using near-infrared cyanine voltage-sensitive dye imaging

Kang

Karakus³

et al. 2019

Preprint

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AbstractDespite current progress achieved in the surgical technique of radical prostatectomy, post-operative complications such as erectile dysfunction and urinary incontinence persist at high incidence rates. In this paper, we present a methodology for functional intra-operative localization of the cavernous nerve (CN) network for nerve-sparing radical prostatectomy using near-infrared cyanine voltage-sensitive dye (VSD) imaging, which visualizes membrane potential variations in the CN and its branches (CNB) in real time. As a proof-of-concept experiment, we demonstrate a functioning complex nerve network in response to electrical stimulation of the CN, which was clearly differentiated from surrounding tissues in an in vivo rat prostate model. Stimulation of an erection was confirmed by correlative intracavernosal pressure (ICP) monitoring. Within 10 minutes, we performed trans-fascial staining of the CN by direct VSD administration. Our findings suggest the applicability of VSD imaging for real-time, functional imaging guidance during nerve-sparing radical prostatectomy.

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Novel methods for mapping the cavernous nerves during radical prostatectomy

Cited by 17 publications

References 104 publications

Recent Advances of Light-Mediated Theranostics

Recent Advances of Light-Mediated Theranostics

Ultrasound capsule endoscopy: sounding out the future

Real-time, functional intra-operative localization of rat cavernous nerve network using near-infrared cyanine voltage-sensitive dye imaging

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