Vitamin D deficiency among native Dutch and first- and second-generation non-Western immigrants

Huibers, Minke H. W.; Visser, Douwe H.; Deckers, Martine; Schoor, Natasja M. van; Furth, A. Marceline van; Wolf, Bart

doi:10.1007/s00431-013-2198-x

Cited by 11 publications

(14 citation statements)

References 22 publications

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“…3 . In a recent cohort study of mother-infant pairs, it was shown that 3-epi-25(OH)D 3 is present at low levels in some pregnant women and fetuses but does not appear to be efficiently transferred transplacentally (20).…”

Section: Origin Of 3-epi-25(oh)dmentioning

confidence: 99%

“…Also, the physiological importance of the C 3 -epimer is heavily debated. In vitro work and rodent models show that 3-epi-25(OH) D 3 and the epimeric form of calcitriol (3-epi-1α,25(OH) 2 D 3 ) bind vitamin D binding protein at 36-46% and vitamin D receptor at 2-3% as compared with non-epimer 25(OH)D 3 and calcitriol (15). However, 3-epi-1α,25(OH) 2 D 3 appears nearly as potent as calcitriol in suppressing parathyroid hormone (16), but it has significantly reduced calcemic effects (17).…”

mentioning

confidence: 99%

“…Transplacental passage of maternal 25-hydroxyvitamin D 3 (25(OH)D 3 ) is the sole source of vitamin D in the developing fetus and implicates that infants are wholly reliant on their mother for their vitamin D status. Given the high prevalence of hypovitaminosis D in pregnant women, supplements are the best way to prevent vitamin D deficiency in infants.…”

mentioning

confidence: 99%

“…itamin D has garnered a great deal of attention in recent years due to a global prevalence of vitamin D deficiency associated with an increased risk of a variety of human diseases (1)(2)(3). Specifically, hypovitaminosis D in pregnant women is highly common and has important implications for the mother and lifelong health of the child, since it has been linked not only to rickets but also to maternal and child infections, small for gestational age, preterm delivery, pre-eclampsia, gestational diabetes, as well as imprinting on the infant for life chronic diseases (4,5).…”

mentioning

confidence: 99%

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Time-course analysis of 3-epi-25-hydroxyvitamin D3 shows markedly elevated levels in early life, particularly from vitamin D supplementation in preterm infants

et al. 2015

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Background: An epimeric form of 25-hydroxyvitamin D 3 (25(OH)D 3 ) has recently been detected in clinical samples, with relatively high levels in infants. Little is known on 3-epi-25(OH) D 3 formation and physiological function. Our objective was to study dynamics of 3-epi-25(OH)D 3 formation during infancy. Methods: 25(OH)D 3 and 3-epi-25(OH)D 3 levels were measured by liquid chromatography-tandem mass spectrometry in 22 preterm (aged 34-37 wk), 15 early preterm (aged <34 wk), and 118 term infants up to 2 y of age. All infants were prescribed vitamin D 400 IU/day after the first week of life. results: At birth, 3-epi-25(OH)D 3 levels were 3 (1-7) nmol/l, <10% of total 25(OH)D 3 . From the second week to 3 mo of age, both 25(OH)D 3 and 3-epi-25(OH)D 3 increased, with highest 3-epi-25(OH)D 3 contribution in early preterm infants (up to 55% of total 25(OH)D 3 vs. 36% in term infants, P < 0.0001). After 3 mo of age, 3-epi-25(OH)D 3 normalized to <10% in all infants. conclusions: At birth, all infants showed low contribution of 3-epi-25(OH)D 3 , increasing the week after starting vitamin D supplementation, until 3 mo of age. Highest levels of 3-epi-25(OH)D 3 were found in early preterm infants, supporting the hypothesis that hepatic immaturity plays a role in 3-epi-25(OH) D 3 formation.

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Section: Origin Of 3-epi-25(oh)dmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

mentioning

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Time-course analysis of 3-epi-25-hydroxyvitamin D3 shows markedly elevated levels in early life, particularly from vitamin D supplementation in preterm infants

et al. 2015

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“…Results of studies in many countries and also national data on Dutch children indicate that prevalence of vitamin D deficiency is not expected to differ in children with or without a fracture (14,17,18,20,21,33,34). Thus, routine vitamin D measurement in children with a fracture should be avoided.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency in Pediatric Fracture Patients: Prevalence, Risk Factors, and Vitamin D Supplementation

Gorter

Oostdijk²,

Felius³

et al. 2016

Jcrpe

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Objective:Although vitamin D levels are not routinely monitored in pediatric fracture patients, identification of children with a vitamin D deficiency may be clinically relevant because of the potential role of vitamin D in fracture healing. This study aimed to determine the prevalence of vitamin D deficiency in a pediatric fracture population and to identify risk factors for deficiency.Methods:All pediatric patients (<18 years) who were treated for a fracture of the upper or lower extremity from September 2012 to October 2013 in the outpatient setting of a level one trauma center were included in this cross-sectional study. Vitamin D deficiency was defined as a serum calcidiol <50 nmol/L. Potential risk factors for vitamin D deficiency were analysed using multivariable logistic regression analysis.Results:A total of 108 boys (58%) and 79 girls, of a mean age 11.1 years (standard deviation 3.9), who had undergone 189 fractures were included in the study. Sixty-four children (34%) were vitamin D deficient. Of those with follow-up measurements, 74% were no longer deficient after supplementation. Vitamin D status did not influence the occurrence of complications during fracture treatment. Independent risk factors for vitamin D deficiency were older age, season (spring), and a non-Caucasian skin type.Conclusion:Clinicians who treat children with a fracture should inform patients and parents on vitamin D supplementation. Vitamin D measurement and supplementation may be needed for children with a non-Caucasian skin type or for those who present with a fracture during spring months.

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Migration and Mental Health: From Vulnerability to Resilience

Galatolo

Biagini

D’Andrea

et al. 2022

Prevention in Mental Health

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Vitamin D deficiency among native Dutch and first- and second-generation non-Western immigrants

Cited by 11 publications

References 22 publications

Time-course analysis of 3-epi-25-hydroxyvitamin D3 shows markedly elevated levels in early life, particularly from vitamin D supplementation in preterm infants

Time-course analysis of 3-epi-25-hydroxyvitamin D3 shows markedly elevated levels in early life, particularly from vitamin D supplementation in preterm infants

Vitamin D Deficiency in Pediatric Fracture Patients: Prevalence, Risk Factors, and Vitamin D Supplementation

Migration and Mental Health: From Vulnerability to Resilience

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