Time-course analysis of 3-epi-25-hydroxyvitamin D3 shows markedly elevated levels in early life, particularly from vitamin D supplementation in preterm infants

Ooms, Nina; Daal, Henny van; Beijers, Antonius M.; Gerrits, G. P. J. M.; Semmekrot, B.A.; Ouweland, Johannes M.W. van den

doi:10.1038/pr.2015.251

Cited by 33 publications

(31 citation statements)

References 27 publications

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“…It is important to note, however, that the concentrations measured by RIA may be falsely elevated by the inclusion of inactive vitamin D metabolites such as 3-epi-25-hydroxyvitamin D as compared with measurements performed through HPLC. 20 Although the absolute values will be higher than studies that use pure 25OHD measures, the trends and associations with vitamin D concentrations seen in our study are valid.…”

Section: Discussionsupporting

confidence: 50%

“…19 In this study, we chose to use the standard clinical RIA measurement to reflect less specific but more clinically relevant levels, with the knowledge that these levels may be falsely elevated by the inclusion of inactive vitamin D metabolites such as 3-epi-25-hydroxyvitamin D or other crossreacting moieties. 20,21 The primary aim of this study was to evaluate the association between vitamin D concentration at birth in term infants with HIE and brain injury as demonstrated by magnetic resonance imaging (MRI). Since vitamin D supplementation is an easy, inexpensive, and safe intervention, it would be an ideal candidate as a supplemental therapy to hypothermia.…”

Section: Introductionmentioning

confidence: 99%

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Neonatal Vitamin D Status Is Associated with the Severity of Brain Injury in Neonatal Hypoxic–Ischemic Encephalopathy: A Pilot Study

et al. 2020

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Objective The primary aim of this study was to evaluate the association between 25-hydroxyvitamin D (25OHD) concentration at birth and the short-term outcomes in neonatal hypoxic–ischemic encephalopathy (HIE). Our secondary aim was to evaluate the effect of postnatal vitamin D supplementation on outcomes in the perinatal period after hypoxic injury. Study Design This retrospective cohort study included all infants ≥35 weeks gestation admitted to a regional level IV neonatal intensive care unit and diagnosed with moderate or severe HIE. Spearman correlation coefficients were used to evaluate associations between clinical outcomes including standardized brain magnetic resonance imaging (MRI) scores and either 25OHD concentrations in the first 48 hours of life or total vitamin D supplementation. Result A total of 43 infants met inclusion criteria; 22 had 25OHD concentrations drawn within the first 48 hours. There was a significant inverse association between 25OHD concentration and brain injury on MRI (p = 0.017). There was a trend toward decreased ventilator days in infants receiving higher doses of vitamin D in the first week of life (p = 0.062), but there was no association between vitamin D dosing and MRI injury. Conclusion These results support an association between lower vitamin-D levels and early adverse outcomes in HIE, including radiographic severity of brain injury.

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Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Neonatal Vitamin D Status Is Associated with the Severity of Brain Injury in Neonatal Hypoxic–Ischemic Encephalopathy: A Pilot Study

et al. 2020

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“…It has been shown that C3-epimer can contribute up to 60% of total 25(OH)D in infants up to 1 year of age. This epimer has been shown also to be elevated, though to a lesser extent, in pregnant women and cord blood (6-10%) [Bailey et al 2013;Karras et al 2013;Ooms et al 2016 …”

Section: Achieving Adequate Maternal Vitamin D Levelsmentioning

confidence: 99%

Maternal vitamin D levels during pregnancy and neonatal health: evidence to date and clinical implications

Karras

Fakhoury

Muscogiuri³

et al. 2016

Therapeutic Advances in Musculoskeletal

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Low maternal vitamin D levels during pregnancy have been associated with a plethora of adverse neonatal outcomes, including small for gestational age and preterm births, detrimental effect on offspring bone and teeth development, and risk of infectious diseases. Although most observational studies indicate a significant linear relationship between maternal 25-hydroxyvitamin D and the above outcomes, some randomized controlled trials to date are inconclusive, mostly due to differences in study design and supplementation regimen. The currently available results indicate that vitamin D supplementation during pregnancy reduces the risk of preterm birth, low birth weight, dental caries of infancy, and neonatal infectious diseases such as respiratory infections and sepsis. This narrative review aims to summarize available trial results regarding the effect of low maternal vitamin D levels during pregnancy, in conjunction with neonatal outcomes on the field, with a discourse on the appropriate clinical approach of this important issue.

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“…The observed increase in serum concentrations of 24,25(OH) 2 D and the epimer 3‐epi‐25‐OH‐D 3 within fetuses of Cyp27b1 null mothers suggests increased production or accumulation of these metabolites of 25OHD. The epimer is known to circulate at higher levels in fetuses and neonates compared with maternal or normal adult values . The physiological relevance of 24,25(OH) 2 D and 3‐epi‐25‐OH‐D 3 are uncertain, but both may contribute to the suppression of PTH in the fetal circulation and may be contributing to the alterations in amniotic fluid calcium and phosphorus and serum calcium.…”

Section: Discussionmentioning

confidence: 99%

Mineral Homeostasis in Murine Fetuses Is Sensitive to Maternal Calcitriol but Not to Absence of Fetal Calcitriol

Ryan

Alhani

Sellars

et al. 2018

Journal of Bone and Mineral Research

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Vitamin D receptor (VDR) null fetuses have normal serum minerals, parathyroid hormone (PTH), skeletal morphology, and mineralization but increased serum calcitriol, placental calcium transport, and placental expression of Pthrp, Trpv6, and (as reported in this study) Pdia3. We examined Cyp27b1 null fetal mice, which do not make calcitriol, to determine if loss of calcitriol has the same consequences as loss of VDR. Cyp27b1 null and wild‐type (WT) females were mated to Cyp27b1+/‐ males, which generated Cyp27b1 null and Cyp27b1+/‐ fetuses from Cyp27b1 null mothers, and Cyp27b1+/‐ and WT fetuses from WT mothers. Cyp27b1 null fetuses had undetectable calcitriol but normal serum calcium and phosphorus, PTH, fibroblast growth factor 23 (FGF23), skeletal mineral content, tibial lengths and morphology, placental calcium transport, and expression of Trpv6 and Pthrp; conversely, placental Pdia3 was downregulated. However, although Cyp27b1+/‐ and null fetuses of Cyp27b1 null mothers were indistinguishable, they had higher serum and amniotic fluid calcium, lower amniotic fluid phosphorus, lower FGF23, and higher 25‐hydroxyvitamin D and 24,25‐dihydroxyvitamin D than in WT and Cyp27b1+/‐ fetuses of WT mothers. In summary, loss of fetal calcitriol did not alter mineral or bone homeostasis, but Cyp27b1 null mothers altered mineral homeostasis in their fetuses independent of fetal genotype. Cyp27b1 null fetuses differ from Vdr null fetuses, possibly through high levels of calcitriol acting on Pdia3 in Vdr nulls to upregulate placental calcium transport and expression of Trpv6 and Pthrp. In conclusion, maternal calcitriol influences fetal mineral metabolism, whereas loss of fetal calcitriol does not. © 2018 American Society for Bone and Mineral Research.

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Time-course analysis of 3-epi-25-hydroxyvitamin D3 shows markedly elevated levels in early life, particularly from vitamin D supplementation in preterm infants

Cited by 33 publications

References 27 publications

Neonatal Vitamin D Status Is Associated with the Severity of Brain Injury in Neonatal Hypoxic–Ischemic Encephalopathy: A Pilot Study

Neonatal Vitamin D Status Is Associated with the Severity of Brain Injury in Neonatal Hypoxic–Ischemic Encephalopathy: A Pilot Study

Maternal vitamin D levels during pregnancy and neonatal health: evidence to date and clinical implications

Mineral Homeostasis in Murine Fetuses Is Sensitive to Maternal Calcitriol but Not to Absence of Fetal Calcitriol

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