Cancer Risk among Children Born after Assisted Conception

Abstract

There was no increase in the overall risk of cancer among British children born after assisted conception during the 17-year study period. Increased risks of hepatoblastoma and rhabdomyosarcoma were detected, but the absolute risks were small. (Funded by Cancer Research UK and others.).

Genetic predisposition in children with cancer – affected families' acceptance of Trio-WES

“…Moreover, neither parental age nor ART seems to be associated with an increased cancer risk in our study cohort. This is in line with previous findings that children born after ART are not at increased cancer risk [15,17].…”

Incidence, Trends, and Survival of Children With Embryonal Tumors

“…In addition, an increased risk of hepatoblastoma has been detected in children born after assisted conception or presumed use of infertility treatment. 42,43 However, for these children as well, the risk seems to be associated with low birth weight and not with assisted conception. 43,44 The premature birth rates increase worldwide including the majority of industrial countries such as Germany.…”

“…42,43 However, for these children as well, the risk seems to be associated with low birth weight and not with assisted conception. 43,44 The premature birth rates increase worldwide including the majority of industrial countries such as Germany. 45 It has been suggested that the improved survival of preterm babies might explain the increasing trend of hepatoblastomas and that some factors in neonatal intensive care could contribute to it.…”

Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE Study

“…A few previous published studies reported positive associations between CL, infertility [8,9] and some fertility treatments [8,[10][11][12], albeit with inconsistency regarding the type of treatment. Petridou et al [12], reported a twofold increase in risk with in vitro fertilization (IVF), but the finding was not replicated by Rudant et al [8] in the ESCALE study or in a recent UK cohort study [13]. On the contrary, the ESCALE study showed an association between CL and ovulation induction without IVF or artificial insemination (AI), suggesting a role of drugs other than gonadotropins.…”