Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE Study

Ajrouche, Roula; Rudant, Jérémie; Orsi, Laurent; Petit, Arnaud; Baruchel, André; Nelken, Brigitte; Pasquet, Marlène; Gautier, Michel; Bergeron, Christophe; Ducassou, Stéphane; Gandemer, Virginie; Lutz, Patrick; Saumet, L.; Rialland, Xavier; Hémon, Denis; Clavel, Jacqueline

doi:10.1007/s10552-014-0429-8

Cited by 37 publications

(38 citation statements)

References 46 publications

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“…The results of recent reports are in line with our findings, such as the ESTELLE case–control study, a French investigation of smaller size compared with the NARECHEM‐BT study, which also reported statistically significant specific associations between maternal history of stillbirth and miscarriage and ALL (OR: 2.6, 95% CI 1.1–5.9) and AML (OR: 1.8, 95% CI 1.1–2.8). In contrast, another French study (Etude Sur les Cancers et les Leucémies de l'Enfant (ESCALE), Study on Environmental and Genetic Risk Factors of Childhood Cancers and Leukemia) reported a null association between history of miscarriages and ALL or AML.…”

Section: Commentsupporting

confidence: 91%

History of Maternal Fetal Loss and Childhood Leukaemia Risk in Subsequent Offspring: Differentials by Miscarriage or Stillbirth History and Disease Subtype

Karalexi

Skalkidou

Thomopoulos

et al. 2015

Paediatric Perinatal Epid

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Differential pathophysiological pathways pertaining to genetic polymorphisms or cytogenetic aberrations are likely to create hostile environments leading either to fetal loss or the development of specific leukaemia subtypes in subsequent offspring, notably distinct associations of maternal miscarriage history confined to AML and stillbirth history confined to ALL (specifically B-ALL). If confirmed and further supported by studies revealing underlying mechanisms, these results may shed light on the divergent leukemogenesis processes.

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Section: Commentsupporting

confidence: 91%

History of Maternal Fetal Loss and Childhood Leukaemia Risk in Subsequent Offspring: Differentials by Miscarriage or Stillbirth History and Disease Subtype

Karalexi

Skalkidou

Thomopoulos

et al. 2015

Paediatric Perinatal Epid

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“…It is also hypothesized that the association with childhood cancers may be due to factors related to underlying subfertility rather than the treatment for infertility itself, as assessed in several studies. Most studies that investigated time to pregnancy or the need for medical consultation for infertility found no association with leukemia, but these studies did not differentiate between women who received treatment for infertility or not [49–54]. A study in Denmark obtained information from the Danish Infertility Cohort, which consists of women with fertility problems referred to medical facilities in Denmark and those with a diagnosis of infertility from the National Patient Register or the Danish IVF registry (e.g.…”

Section: Discussionmentioning

confidence: 99%

Parental age and childhood cancer risk: A Danish population-based registry study

Contreras

Hansen

Ritz

et al. 2017

Cancer Epidemiology

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Background Though the association between parental age at child’s birth and the risk of childhood cancer has been previously investigated, the evidence to date is inconclusive and scarce for rarer cancer types. Methods Cancer cases (N=5,856) were selected from all children born from 1968–2014 and diagnosed from 1968–2015 in Denmark at less than 16 years of age listed in the nationwide Danish Cancer Registry. Cases were individually matched to controls (1:100) on sex and year of birth with a total of 585,594 controls randomly sampled from all live births in Denmark from the Danish Central Population Registry. Parental age at child’s birth was extracted from the Central Population Registry. Conditional logistic regression models were used to estimate odds ratios for the association between parental age at child’s birth and childhood cancer risk. Parental age was modeled as both categorical (referent group, parents aged 25–29) and continuous per 5-year increase in age. Results Offspring of older mothers were at an increased risk of acute lymphoblastic leukemia (ALL) [OR=1.10, 95% CI: (1.02, 1.19) per 5-year increase in age]. Older maternal age (40+) increased the risk of non-Hodgkin lymphoma (NHL) [OR=1.96, 95%CI: (1.12, 3.43)]. The risk of Wilms’ tumor also appeared elevated with older paternal age [OR=1.11, 95% CI: (0.97, 1.28) per 5-year increment in age]. Conclusion Older parental age was a risk factor for various childhood cancers in Danish children. Further investigation of the biological and social factors that may be contributing to these associations is warranted.

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“…A study in France showed an association between leukemia and ovulation induction but not with in vitro fertilization [42]. Another study by the same group in France did not confirm this association nor with specific types of ovulation induction medication [43]. Finally, it is possible that the association with ovulation induction treatment might be related to factors underlying fertility problems [44], and not the treatment itself.…”

Section: Discussionmentioning

confidence: 99%

Environmental, maternal, and reproductive risk factors for childhood acute lymphoblastic leukemia in Egypt: a case-control study

et al. 2016

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BackgroundAcute lymphocytic leukemia (ALL) is the most common pediatric cancer. The exact cause is not known in most cases, but past epidemiological research has suggested a number of potential risk factors. This study evaluated associations between environmental and parental factors and the risk for ALL in Egyptian children to gain insight into risk factors in this developing country. Methods: We conducted a case-control design from May 2009 to February 2012. Cases were recruited from Children’s Cancer Hospital, Egypt (CCHE). Healthy controls were randomly selected from the general population to frequency-match the cumulative group of cases by sex, age groups (<1; 1 – 5; >5 – 10; >10 years) and region of residence (Cairo metropolitan region, Nile Delta region (North), and Upper Egypt (South)). Mothers provided answers to an administered questionnaire about their environmental exposures and health history including those of the father. Odds ratios (ORs) and 95 % confidence intervals (CI) were calculated using logistic regression with adjustment for covariates.ResultsTwo hundred ninety nine ALL cases and 351 population-based controls frequency-matched for age group, gender and location were recruited. The risk of ALL was increased with the mother’s use of medications for ovulation induction (ORadj = 2.5, 95 % CI =1.2 –5.1) and to a lesser extend with her age (ORadj = 1.8, 95 % CI = 1.1 – 2.8, for mothers ≥ 30 years old). Delivering the child by Cesarean section, was also associated with increased risk (ORadj = 2.01, 95 % CI =1.24–2.81).ConclusionsIn Egypt, the risk for childhood ALL appears to be associated with older maternal age, and certain maternal reproductive factors.

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Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE Study

Cited by 37 publications

References 46 publications

History of Maternal Fetal Loss and Childhood Leukaemia Risk in Subsequent Offspring: Differentials by Miscarriage or Stillbirth History and Disease Subtype

History of Maternal Fetal Loss and Childhood Leukaemia Risk in Subsequent Offspring: Differentials by Miscarriage or Stillbirth History and Disease Subtype

Parental age and childhood cancer risk: A Danish population-based registry study

Environmental, maternal, and reproductive risk factors for childhood acute lymphoblastic leukemia in Egypt: a case-control study

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