Incidence, Trends, and Survival of Children With Embryonal Tumors

Tulla, Mira; Berthold, Frank; Graf, Norbert; Rutkowski, Stefan; Schweinitz, Dietrich von; Spix, Claudia; Kaatsch, Peter

doi:10.1542/peds.2015-0224

Cited by 56 publications

(56 citation statements)

References 51 publications

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“…In our study we did not find a difference in survival between the TYA age group and children aged 5-9 years. We did however observe a doubling of the risk of death for those aged under 5 years, consistent with other studies (3,5,(15)(16)(17)(18)(19)31) due to treatment strategies for infants and young children that defer or avoid radiation (7).…”

Section: Discussionsupporting

confidence: 91%

“…Central nervous system (CNS) tumours are the second most common site of neoplasms diagnosed in children, accounting for approximately one quarter of all childhood cancers (0-14 years), (1) and 14% of tumours diagnosed in teenagers and young adults (TYA) (15)(16)(17)(18)(19)(20)(21)(22)(23)(24) years) (2). They are the most common cause of cancer related death in children and TYA (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…Population-based studies which have analysed survival rates separately for medulloblastoma and CNS PNET have shown that children diagnosed with medulloblastoma have better survival outcomes than those with CNS PNET (5-year survival rates range between 58-69% for medulloblastoma vs. 27-47% for CNS PNET) (3,(15)(16)(17)(18). The incidence of childhood CNS embryonal tumours increased in Europe between 1978 and 1997 (19).…”

Section: Introductionmentioning

confidence: 99%

“…Analysis by subgroup in children in Germany found that incidence trends for medulloblastoma in children have remained stable between 1991 and 2012 while over the same period the PNET rate decreased mainly due to improved diagnostic tools and classification of tumours (18).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Incidence and survival of children and young people with central nervous system embryonal tumours in the North of England, 1990–2013

Fairley

Picton

McNally

et al. 2016

European Journal of Cancer

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Incidence and survival of children and young people with central nervous system embryonal tumours in the North of England, 1990–2013

Fairley

Picton

McNally

et al. 2016

European Journal of Cancer

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“…This is in contrast with other studies, which have identified the male sex as a risk factor for neuroblastoma. 46,47 Childhood carcinomas are rare. Consequently, they occurred infrequently in children with cancer who were treated at the NCI.…”

Section: Gender Percentage (%)mentioning

confidence: 99%

Epidemiological review of childhood cancers in central Sudan

et al. 2018

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Background: Epidemiological studies of paediatric cancer incidence in Sudan are rare.Objectives: The aim of this study was to provide baseline information about the epidemiology of childhood cancers in patients treated at the National Cancer Institute (NCI) in Wad Medani, Sudan.Methods: We performed a retrospective health facility–based study of cancer incidence and patient characteristics of children who were treated at the NCI from January 1999 to December 2015. The changing patterns of cancers incidence during the study period were also recorded.Results: Of 15 387 new patients with cancer who were registered at the NCI during the study period, 1159 (7.5%) were children (younger than 15 years). The mean age of the paediatric patients was 7 years, with standard deviation of 5. Most of the patients (36%) were 10 to 15 years old, 33% were 0 to 4 years old and 31% were 5 to 10 years old. Among the study population, 60% were males and 40% were females. Approximately 76% of children lived in rural areas in Sudan. Leukaemias (29%) and lymphomas (26%) comprised 55% of all paediatric cancers. Central nervous system (CNS) tumours constituted 6% of all paediatric tumours, whereas non-CNS embryonal tumours (i.e. nephroblastoma, neuroblastoma, hepatoblastoma and retinoblastoma) accounted for 20%. The average number of cases per year increased from 42 in 1999–2005 to 75 in 2006–2010 and 106 in 2011–2015.Conclusion: The number of patients seeking treatment for childhood cancers has increased every year in central Sudan. Leukaemias and lymphomas constitute more than half of these cancers. A population-based cancer registry is needed to determine the true incidence of childhood cancers in Sudan.

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The utility of alpha‐fetoprotein screening in Beckwith–Wiedemann syndrome

Duffy

Deardorff

Kalish

2017

American J of Med Genetics Pt A

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Beckwith-Wiedemann syndrome (BWS) is one of the most common cancer predisposition disorders. As a result, BWS patients receive tumor screening as part of their clinical management. Until recently, this screening has been employed uniformly across all genetic and epigenetic causes of BWS, including the utilization of ultrasonography to detect abdominal tumors and alpha-fetoprotein (AFP) to detect hepatoblastoma. The advancements in our understanding of the genetics and epigenetics leading to BWS has evolved over time, and has led to the development of genotype/phenotype correlations. As tumor risk appears to correlate with genetic and epigenetic causes of BWS, several groups have proposed alterations to tumor screening protocols based on the etiology of BWS, with the elimination of AFP as a screening measure and the elimination of all screening measures in BWS patients with loss of methylation at the KCNQ1OT1:TSS-DMR 2 (IC2). There are many challenges to this suggestion, as IC2 patients may have additional factors that contribute to risk of hepatoblastoma including fetal growth patterns, relationship with assisted reproductive technologies, and the regulation of the IC2 locus.

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Incidence, Trends, and Survival of Children With Embryonal Tumors

Cited by 56 publications

References 51 publications

Incidence and survival of children and young people with central nervous system embryonal tumours in the North of England, 1990–2013

Incidence and survival of children and young people with central nervous system embryonal tumours in the North of England, 1990–2013

Epidemiological review of childhood cancers in central Sudan

The utility of alpha‐fetoprotein screening in Beckwith–Wiedemann syndrome

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