Mucoadhesive hybrid gel improves intraperitoneal platinum delivery

Cho, Sungpil; Sun, Yongen; Jarboe, Elke A.; Soisson, Andrew P.; Dodson, Mark K.; Gaffney, David K.; Janát-Amsbury, Margit M.

doi:10.1016/j.ijpharm.2013.09.035

Cited by 7 publications

(3 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…General theories of the molecular basis of adhesion have been applied to the discussion of mucoadhesion [31]. Chitosan performs well as a mucoadhesive dosage form both in vivo [32][33][34][35][36][37][38] and in vitro [2,25,26,28,[39][40][41][42][43][44][45][46] and it is therefore of interest to determine the strength of the basic interactions related to this important property.…”

Section: Introductionmentioning

confidence: 99%

Direct Determination of Chitosan–Mucin Interactions Using a Single-Molecule Strategy: Comparison to Alginate–Mucin Interactions

et al. 2015

View full text Add to dashboard Cite

Aqueous chitosan possesses attractive interaction capacities with various molecular groups that can be involved in hydrogen bonds and electrostatic and hydrophobic interactions. In the present paper, we report on the direct determination of chitosan-mucin molecular pair interactions at various solvent conditions as compared to alginate-mucin interactions. Two chitosans of high molecular weight with different degrees of acetylation-thus possessing different solubility profiles in aqueous solution as a function of pH and two alginates with different fractions of α-guluronic acid were employed. The interaction properties were determined through a direct unbinding assay at the single-molecular pair level using an atomic force microscope. When probed against immobilized mucin, both chitosans and alginates revealed unbinding profiles characteristic of localized interactions along the polymers. The interaction capacities and estimated OPEN ACCESSPolymers 2015, 7 162 parameters of the energy landscapes of the pairwise chitosan-mucin and alginate-mucin interactions are discussed in view of possible contributions from various fundamental forces. Signatures arising both from an electrostatic mechanism and hydrophobic interaction are identified in the chitosan-mucin interaction properties. The molecular nature of the observed chitosan-mucin and alginate-mucin interactions indicates that force spectroscopy provides fundamental insights that can be useful in understanding the surface binding properties of other potentially mucoadhesive polymers.

show abstract

Section: Introductionmentioning

confidence: 99%

Direct Determination of Chitosan–Mucin Interactions Using a Single-Molecule Strategy: Comparison to Alginate–Mucin Interactions

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The functionalization of anti‐CD133 prolonged the median survival rate in the IP treatment of Pt‐prodrug loaded carbon nanotubes. Janat‐Amsbury and coworkers showed that IP administration of a cisplatin loaded polymeric hybrid gel (HG‐CDDP) exhibited higher cisplatin accumulation in the genomic DNA of peritoneal tissues than that observed by IV injection . Recently, in situ crosslinkable hydrogels based on hyaluronic acid (HA) derivatives were designed for IP delivery of cisplatin for local therapy of ovarian cancer .…”

Section: Local Platinum Drug Delivery Strategiesmentioning

confidence: 99%

“…Janat-Amsbury and coworkers showed that IP administration of a cisplatin loaded polymeric hybrid gel (HG-CDDP) exhibited higher cisplatin accumulation in the genomic DNA of peritoneal tissues than that observed by IV injection. 169 Recently, in situ crosslinkable hydrogels based on hyaluronic acid (HA) derivatives were designed for IP delivery of cisplatin for local therapy of ovarian cancer. 25 However, cisplatin loaded nanogels did not show a better efficacy than free cisplatin, but rather induced a slight increase in tumor burdens in the later time points, suggesting that the empty carriers or degraded products may have unexpected biological effects on the residual tumors.…”

Section: Intraperitoneal Deliverymentioning

confidence: 99%

Multifunctional platinum‐based nanoparticles for biomedical applications

Cheng

Liu

2016

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Platinum-based anticancer drugs play a central role in current cancer therapy. However, their applicability and efficacy are limited by drug resistance and adverse effects. Nanocarrier-based platinum drug delivery systems are promising alternatives to circumvent the disadvantages of bare platinum drugs. The various properties of nanoparticle chemistry allow for the trend toward multiple functionality. Nanoparticles preferentially accumulate at the tumor site through passive targeting, and the attachment of tumor targeting moieties further enhances their tumor-specific localization as well as tumor cell uptake. The introduction of stimuli-responsive groups into drug delivery systems can further achieve spatially and temporally controlled drug release in response to specific stimuli. Combination therapy strategies have been used to promote synergetic efficacy and overcome the resistance of platinum drugs. The tumor-localized drug delivery strategies exhibit benefits for preventing local tumor recurrence. In addition, the combination of platinum drugs and imaging agents in one unity allows the cancer diagnostics for real-time monitoring the distribution of drug-loaded nanoparticles inside the body and tumor. This review discusses recent scientific advances in multifunctional nanoparticle formulations of platinum drugs, and these designs exhibit new potential of multifunctional nanoparticles for delivering platinum-based anticancer drugs. WIREs Nanomed Nanobiotechnol 2017, 9:e1410. doi: 10.1002/wnan.1410 For further resources related to this article, please visit the WIREs website.

show abstract