Development of mucoadhesive hydrogels based on polyacrylic acid grafted cellulose nanocrystals for local cisplatin delivery

Vakili, Mohammad Reza; Mohammed-Saeid, Waleed; Aljasser, Abdullah; Hopwood-Raja, Julian; Ahvazi, Bijan; Hrynets, Yuliya; Betti, Mirko; Lavasanifar, Afsaneh

doi:10.1016/j.carbpol.2020.117332

Cited by 49 publications

(16 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CNC PAA 9: CDDP complex has significant enhancement in the IC50 of a drug that has a 3-fold increase against HCT 116 cells. CNC PAA does not have any cytotoxicity, and these results have shown that CNC PAA is a good method for local platinum delivery in colorectal cancer as a mucoadhesive hydrogel [267]. A similar study based on CNC was done by Sarkar et al, the main goal of the study being to get good bioavailability and a prolonged residence time.…”

Section: Cellulose Nanocrystalsmentioning

confidence: 72%

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

et al. 2021

View full text Add to dashboard Cite

One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems.

show abstract

Section: Cellulose Nanocrystalsmentioning

confidence: 72%

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Chemical Modifications Of Polymersmentioning

confidence: 99%

“…37 Vakili et al have reported grafting of PAA over cellulose nanocrystals to improve mucoadhesion and mechanical properties and thus deliver the cisplatin drug to the site of colorectal cancer. 38 Alginates, representative of negatively charged polysaccharides, are well-known mucoadhesive polymers and are frequently used in the production of microparticles. 39 These anionic polymers interact with the oligosaccharide chains of mucin by way of hydrogen bonding.…”

Section: Functional Modifications Of Anionic Polymersmentioning

confidence: 99%

Recent advances in functionally modified polymers for mucoadhesive drug delivery

2022

View full text Add to dashboard Cite

show abstract

“…This indicates that, by adding A40, we could increase the steric barriers on the surface of CNC so that the aggregated CNC particles were separated and size was reduced. When the stick-shaped CNC is connected with A40, it should form a long stick connected with multiple A40 dispersants [38,39], as shown in Figure 5c. Finally, the multi-branched sticks were adsorbed to the surface of the TCP, forming stronger steric barriers, so as to more effectively disperse the TCP.…”

Section: Influence Of Cnc Towards β-Tcp Suspensionsmentioning

confidence: 99%

Enhancing Stability of High-Concentration β-Tricalcium Phosphate Suspension for Biomedical Application

et al. 2022

View full text Add to dashboard Cite

We propose a novel process to efficiently prepare highly dispersed and stable Tricalcium Phosphate (β-TCP) suspensions. TCP is coupled with a polymer to enhance its brittleness to be used as an artificial hard tissue. A high solid fraction of β-TCP is mixed with the polymer in order to improve the mechanical strength of the prepared material. The high solid fractions led to fast particle aggregation due to Van der Waals forces, and sediments appeared quickly in the suspension. As a result, we used a dispersant, dispex AA4040 (A40), to boost the surface potential and steric hindrance of particles to make a stable suspension. However, the particle size of β-TCP is too large to form a suspension, as the gravity effect is much more dominant than Brownian motion. Hence, β-TCP was subjected to wet ball milling to break the aggregated particles, and particle size was reduced to ~300 nm. Further, to decrease sedimentation velocity, cellulose nanocrystals (CNCs) are added as a thickening agent to increase the overall viscosity of suspension. Besides the viscosity enhancement, CNCs were also wrapped with A40 micelles and increase the stability of the suspension. These CNC/A40 micelles further facilitated stable suspension of β-TCP particles with an average hydration radius of 244.5 nm. Finally, β-TCP bone cement was formulated with the suspension, and the related cytotoxicity was estimated to demonstrate its applicability for hard tissue applications.

show abstract

Development of mucoadhesive hydrogels based on polyacrylic acid grafted cellulose nanocrystals for local cisplatin delivery

Cited by 49 publications

References 33 publications

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

Recent advances in functionally modified polymers for mucoadhesive drug delivery

Enhancing Stability of High-Concentration β-Tricalcium Phosphate Suspension for Biomedical Application

Contact Info

Product

Resources

About