Recent advances in functionally modified polymers for mucoadhesive drug delivery

Surendranath, Medha; Rekha, M.R.; Ramesh, P.

doi:10.1039/d2tb00856d

Cited by 18 publications

(14 citation statements)

References 97 publications

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“…For drug delivery purposes, the mucoadhesion implies the attachment of a drug delivery system to the mucous coat on the surface of the target tissues [ 96 , 97 , 98 ]. Several simultaneous interfacial interactions are involved in the complex mucoadhesion process, and the interactions can occur through covalent bonds or supramolecular interactions (including hydrogen bond and hydrophobic/electrostatic interactions) [ 96 , 99 , 100 , 101 ]. In the pH M modifying buccal/sublingual formulations, polymers with a fairly good mucoadhesion are applied to extend the retention time of the formulations on the oral mucosa.…”

Section: Challengesmentioning

confidence: 99%

Microenvironmental pH Modification in Buccal/Sublingual Dosage Forms for Systemic Drug Delivery

He¹,

2023

Pharmaceutics

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Many drug candidates are poorly water-soluble. Microenvironmental pH (pHM) modification in buccal/sublingual dosage forms has attracted increasing interest as a promising pharmaceutical strategy to enhance the oral mucosal absorption of drugs with pH-dependent solubility. Optimizing drug absorption at the oral mucosa using pHM modification is considered to be a compromise between drug solubility and drug lipophilicity (Log D)/permeation. To create a desired pHM around formulations during the dissolution process, a suitable amount of pH modifiers should be added in the formulations, and the appropriate methods of pHM measurement are required. Despite pHM modification having been demonstrated to be effective in enhancing the oral mucosal absorption of drugs, some potential risks, such as oral mucosal irritation and teeth erosion caused by the pH modifiers, should not been neglected during the formulation design process. This review aims to provide a short introduction to the pHM modification concept in buccal/sublingual dosage forms, the properties of saliva related to pHM modification, as well as suitable drug candidates and pH modifiers for pHM modifying buccal/sublingual formulations. Additionally, the methods of pHM measurement, pHM modification methods and the corresponding challenges are summarized in the present review.

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Section: Challengesmentioning

confidence: 99%

Microenvironmental pH Modification in Buccal/Sublingual Dosage Forms for Systemic Drug Delivery

He¹,

2023

Pharmaceutics

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“…Recent advances in mucoadhesive polymers for oral mucosa include functional modifications of anionic, cationic, and nonionic polymers to increase these polymer–mucin interactions. The insertion of catechol functional groups in polymers enhances mucoadhesion, as it occurs by methylation of the amino group, the increase in the degree of quaternization, and the conjugation of boronate groups and thiolathion (Surendranath et al 2022). Methacrylation also promotes mucoadhesion due to the Michael-type addition reactions (Surendranath et al 2022).…”

Section: Advances In Mucoadhesion and Delivery Systemsmentioning

confidence: 99%

Mucoadhesive Vaccine Delivery Systems for the Oral Mucosa

Mokabari

Varoni

2023

J Dent Res

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Vaccine technology has evolved continuously since its beginning, and mucosal vaccination, including intranasal, sublingual, and oral administrations, has recently gained great scientific interest. The oral mucosa represents a promising minimally invasive route for antigen delivery, mainly at sublingual and buccal mucosal sites, and it is easily accessible, immunologically rich, and able to promote an effective systemic and local immune response. The aim of this review is to provide an updated overview on the technologies for oral mucosal vaccination, with emphasis on mucoadhesive biomaterial-based delivery systems. Polymeric-based nanoparticles, multilayer films and wafers, liposomes, microneedles, and thermoresponsive gels are the most investigated strategies to deliver antigens locally, showing mucoadhesive properties, controlled release of the antigen, and the ability to enhance immunological responses. These formulations have achieved adequate properties in terms of vaccine stability, are minimally invasive, and are easy to produce and manage. To date, oral mucosa vaccine delivery systems represent a promising and open field of research. Future directions should focus on the role of these systems to induce sustained innate and adaptive immune responses, by integrating the recent advances achieved in mucoadhesion with those related to vaccine technology. Being painless, easy to administer, highly stable, safe, and effective, the antigen delivery systems via the oral mucosa may represent a useful and promising strategy for fast mass vaccination, especially during pandemic outbreaks.

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“…[11][12][13] Important aspect to consider for the development of mucoadhesive film is the contact time of the drug and cancer cells. [14][15][16] The residence time of mucoadhesive oral films on the oral mucosa has been enhanced to improve the drug partitioning to target tissue to overcome the oral mucosa penetration barrier. [17] As a result, these strategies may significantly advance the development of a sustained and targeted drug delivery system for oral cavity tissues.…”

Section: Original Articlementioning

confidence: 99%

Untitled

2022

AJP

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Background: Oral cancer affects millions of people worldwide, which is more common in those 35 and older. Low-targeted therapy options for oral malignancies and poor drug uptake by lesions in the oral cavity followed by systemic injection contribute to high mortality and poor patient quality of life. Aim: The present study was undertaken for optimization and assessment of the designed cisplatin mucoadhesive film made of hydroxyl propyl methyl cellulose and chitosan that can be used locally to treat oral cancer. Materials and Methods: The films were prepared by solvent casting method, employing a Box-Behnken design, and subsequently confirmed by ANOVA analysis. The formulations were optimized by swelling index and residence time. Physiochemical characteristics of oral films, including pH, weight, thickness, tensile strength, folding endurance, and in vitro drug release, were also assessed. Results and Discussion: According to the factors selected for the optimization, the formulation (F3) was selected as the optimized formulation with highest desirability of 0.997. In vitro release profile indicated initial burst release and subsequently a sustained release of cisplatin from the film for 24 h. The release kinetics data displayed a Korsmeyer-Peppas release model with the best-fit match R 2 value (0.9257). In vitro exposing the KB-3-1 cell line to the optimized film resulted in dose-dependent cancer cell death. The IC 50 of free cisplatin and cisplatin mucoadhesive film (F3) on KB-3-1 was found to be 94.25 μg/ml and 23.64 μg/ml, respectively. This study demonstrates that local bioadhesive therapies are effective in treating cancer of the oral cavity. Conclusion: On the basis of data, it could be concluded that the number of polymers used was the critical factor for the production of cisplatin mucoadhesive film that had a substantial influence on their physical attributes. This factorial design study has served as a valuable tool for optimizing mucoadhesive film for the delivery of cisplatin.

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Recent advances in functionally modified polymers for mucoadhesive drug delivery

Abstract: Novel methods for the delivery of drugs other than the conventional method of oral administration had been a thrust area of research for a few decades. Mucoadhesive delivery of drugs...

Cited by 18 publications

References 97 publications

Microenvironmental pH Modification in Buccal/Sublingual Dosage Forms for Systemic Drug Delivery

Microenvironmental pH Modification in Buccal/Sublingual Dosage Forms for Systemic Drug Delivery

Mucoadhesive Vaccine Delivery Systems for the Oral Mucosa

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