Positive association between Interleukin-8 -251A > T polymorphism and susceptibility to gastric carcinogenesis: a meta-analysis

Abstract

BackgroundsThe associations between the polymorphisms of interleukin-8 (IL-8) gene and gastric carcinogenesis have been extensively investigated in recent years. However, the results remain conflicting rather than conclusive.MethodsA meta-analysis of 18 eligible studies was performed to evaluate the association of IL-8 -251A > T polymorphism with risk of gastric carcinogenesis. A systematic literature search of MEDLINE, Embase, and Web of Science, CNKI databases was conducted. Statistical analysis was performed by using the Revman 5.1 software and the Stata 12.0 software.ResultsOf the 293 unique studies identified using our search criteria, 18 studies fulfilled our inclusion criteria and were included in the meta-analysis. These studies cumulatively reported 5,321 cases and 6,465 controls. The combined results based on all studies showed that the IL-8 -251A > T polymorphism was associated with the risk of gastric carciongenesis (A vs. T: OR: 1.14 [1.02, 1.26], P = 0.02), especially gastric cancer (A vs. T: OR: 1.15 [1.03, 1.29], P = 0.02), but not associated with the risk of precancerous lesion (A vs. T: OR: 1.09 [0.99, 1.20], P = 0.08). Analysis stratified by ethnicity may seem that IL-8 -251A > T polymorphism was susceptible to gastric cancer in Asian population, but not in Caucasian population.ConclusionsOur meta-analysis results provide evidence that IL-8 -251A > T polymorphism is significantly associated with increased risk of gastric carcinogenesis in Asian population, particularly in gastric cancer. Further large and well-designed studies are required to confirm this conclusion.

The Role of Interleukin-8 and Its Mechanism in Patients with Breast Cancer: Its Relation with Oxidative Stress and Estrogen Receptor

“…Chemotactic cytokines, which is produced by tumor and endothelial cells, can play an important role in cancer including angiogenesis, progression of tumor, migration, and facilitating evasion of immune surveillance (16 (24) and acts as a member of Glu-Leu-Arg (ELR) motif positive Cysteine-X-Cysteine (CXC) (25) chemokine (26)(27)(28) secreted by tumor cells (25). It is also mainly secreted by monocytes and endothelial cells (4,29).…”

Contribution of Genetic Polymorphisms of Inflammation Response Genes on Sporadic Colorectal Cancer Predisposition Risk in Malaysian Patients – A Case Control Study

“…However, few other meta-analyses on the association of this polymorphism with other cancers showed a positive association with some of the cancers. An association of this polymorphism was reported by Cheng et al, (2013) for gastric cancer risk in Asian population, for Oral cancer risk in Caucasian population by and for renal cell cancer risk by Chen et al, (2016) in Chinese Han population. In a meta-analysis on association between IL-8 -251 T>A and risk of lung cancer done by Gao et al, (2014), the results showed that the IL-8-251A/T polymorphism was associated with lung cancer susceptibility in Asians and the -251 A allele may increase risk of lung cancer in Asians.…”

Interleukin‐8 ‐251A/T gene polymorphism and lung cancer susceptibility: a meta‐analysis

“…Recently, variants of the IL-8 gene involved in the aetiology of several cancers have drawn increasing attention. Recently, two meta-analysis [26,27] about Interleukin-8 -251A > T polymorphism indicated that the polymorphism interleukin-8 -251A/T is associated with a significantly increased risk of gastric carcinogenesis, breast cancer and nasopharyngeal carcinoma. This meta-analysis summarize all the available data on the association between IL-8 -251T/A polymorphism and lung cancer risk, including a total of 3265 lung cancer cases and 3607 controls.…”