Interleukin‐8 ‐251A/T gene polymorphism and lung cancer susceptibility: a meta‐analysis

Wang, Xiaobin; Li, Yunsong; Li, Jie; Ye, Han; Liu, Zhidong

doi:10.1111/jcmm.12466

Cited by 16 publications

(12 citation statements)

References 33 publications

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“…[2,26,27] A functional polymorphism –251T>A in the proximal promoter region of IL-8 gene has been ever found to be associated with several inflammatory diseases, such as bronchial asthma, [28] gastritis, [29] and pancreatitis, [30] which may be due to the frequently reported relationship between –251A allele and higher IL-8 transcription activity, thereby which is able to result in altered susceptibility to diseases. [31] Likewise, studies regarding the association of IL-8 gene polymorphism –251T>A with susceptibility to AD in populations have emerged in recent years, however, obtained discrepant results. Mai et al [21] and Kang et al [18] found an overall significant association between the IL-8 gene –251T>A variant and increased individual susceptibility to AD, whereas other studies failed to reveal such association, [20,22,24] which prompted the further investigations to verify the association with a large-scare sample size.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-8 gene polymorphism –251T>A contributes to Alzheimer's disease susceptibility

Qin

Li²,

Wang³

et al. 2016

Medicine

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Background:Published association studies have investigated the correlation between interleukin-8 (IL-8) gene polymorphism –251T>A and susceptibility to Alzheimer's disease (AD); however, the results are conflicting. Thus, we conducted the meta-analysis to reassess the effect of IL-8 gene –251T>A variant on the risk of AD.Methods:Relevant studies regarding this association were electronically searched and identified from the PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and the Chinese Biomedicine Database. The odds ratios (ORs) with the corresponding 95% confidence intervals (95% CIs) were pooled to calculate the strength of this association.Results:Nine studies with a total of 1406 cases and 2152 controls were included in the meta-analysis. Overall, a significant association of IL-8 gene –251T>A polymorphism with increased risk of AD was observed in several genetic models (allele, A vs T: OR=1.32, 95%CI=1.16-1.50; homozygous, AA vs TT: OR=1.70, 95%CI=1.21–2.21; heterozygous, TA vs TT: OR=1.37, 95%CI=1.12–1.69; recessive, AA vs TA+TT: OR=1.40, 95%CI=1.12–1.75). Similarly, such association was also revealed both in Asian and European populations in the subgroup analysis by ethnicity.Conclusion:The current study suggested that IL-8 gene polymorphism –251T>A may contribute to the susceptibility to AD.

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Section: Discussionmentioning

confidence: 99%

Interleukin-8 gene polymorphism –251T>A contributes to Alzheimer's disease susceptibility

Qin

Li²,

Wang³

et al. 2016

Medicine

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“…Several studies have reported the association between polymorphisms in the IL-8 gene and the development of different types of cancers, including liver, gastric, lung, ovarian, and colorectal cancers (Burada et al, 2013;Yang et al, 2014;Koensgen et al, 2015;Kumar et al, 2015;Wang et al, 2014Wang et al, , 2015. A previous meta-analysis conducted by Yang et al (2014) indicated that the IL-8 rs4073 gene polymorphism does not influence the susceptibility to oral cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Wang et al (2015) suggested that mutations in the IL-8 gene confer an increased risk of lung cancer in Asians. Another study discovered an association between the IL-8 +781 and +2767 polymorphisms and susceptibility to ovarian cancer in a German population (Koensgen et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Role of IL-8 gene polymorphisms in glioma development in a Chinese population

Fu¹,

Wang²,

Qi³

2016

Genet. Mol. Res.

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ABSTRACT. This case-control study aimed to investigate the role of -251 T>A (rs4073) and -781 C>T (rs2227306) polymorphisms in the interleukin-8 (IL-8) gene in the development of glioma in a Chinese population. One hundred and twenty-seven glioma patients and 284 healthy control subjects were recruited to this study between February 2013 and December 2014. The IL-8 -251 T>A (rs4073) and -781 C>T (rs2227306) polymorphisms were genotyped by polymerase chain reaction coupled with restriction fragment length polymorphism. The patients and control subjects were comparable by gender (c 2 = 1.24, P = 0.27), tobacco smoking status (c 2 = 0.80, P = 0.37), alcohol consumption status (c 2 = 0.97, P = 0.32), and family history of cancer (c 2 = 1.54, P = 0.22). The age of glioma patients was statistically lower than that of control subjects (t = 2.87, P = 0.002). The chisquare test revealed the lack of any statistically significant differences in the genotype distributions of IL-8 rs4073 (c 2 = 0.89, P = 0.64) and rs2227306 (c 2 = 2.58, P = 0.28) between the glioma patients and control subjects. Unconditional logistic regression analysis revealed that the IL-8 rs4073 and rs2227306 gene polymorphisms did not contribute to the development of glioma. In conclusion, we determined that there is a lack of evidence suggesting a significant association between the IL-8 rs4073 and rs2227306 gene polymorphisms and the development of glioma in a Chinese population.

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“… 23 – 26 A large number of studies have investigated associations between the CXCL8 −251 A/T (rs4073) gene polymorphism and the risk of human cancers, with conflicting conclusions. 27 – 32 …”

Section: Introductionmentioning

confidence: 99%

Association of IL-8 gene promoter -251 A/T and IL-18 gene promoter -137 G/C polymorphisms with head and neck cancer risk: a comprehensive meta-analysis

Wang¹,

Gao²,

Huang³

et al. 2018

CMAR

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PurposeNo consensus exists on the impact of polymorphisms in cytokines (such as interleukin IL-8 and IL-18) on cancer risk; moreover, there is very little evidence regarding head and neck cancer (HNC).MethodsThus, a meta-analysis including 22 studies with 4731 cases and 8736 controls was conducted to evaluate this association. The summary odds ratio (OR) and corresponding 95% confidence intervals (CIs) for C-X-C motif chemokine ligand 8 (CXCL8, which encodes IL-8) and IL-18 polymorphisms and HNC risk were estimated.ResultsThe results showed a significantly increased risk of HNC susceptibility for IL18 −137 G/C in five genetic models, but, interestingly, no significant association was found for the CXCL8 −251 A/T polymorphism. When stratified by cancer type, an increased risk of nasopharyngeal cancer was found for both −137 G/C and −251A/T. When the studies were stratified by ethnicity and genotyping method, there were significant associations between Asian populations and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) studies for −137 G/C, and African populations for −251 A/T in some genetic models. A positive association was also found between the population-based groups in some models for −137 G/C; conversely, significantly decreased risk was found among the −251 A/T hospital-based group. Meta-regression was also conducted. The publication year, control source, and cancer type contributed to CXCL8 −251 A/T heterogeneity; however, no factors were found that contributed to IL-18 −137 G/C heterogeneity. Marginal significance was found in the recessive model for IL-18 −137 G/C by Egger’s test, whereas no publication bias was detected for CXCL8 −251 A/T.ConclusionsThe results indicate that the IL-18 −137 G/C polymorphism is associated with HNC risk, especially nasopharyngeal cancer, in Asian populations and, when using PCR-RFLP, CXCL8 −251 A/T polymorphisms play a complex role in HNC development.

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Interleukin‐8 ‐251A/T gene polymorphism and lung cancer susceptibility: a meta‐analysis

Cited by 16 publications

References 33 publications

Interleukin-8 gene polymorphism –251T>A contributes to Alzheimer's disease susceptibility

Interleukin-8 gene polymorphism –251T>A contributes to Alzheimer's disease susceptibility

Role of IL-8 gene polymorphisms in glioma development in a Chinese population

Association of IL-8 gene promoter -251 A/T and IL-18 gene promoter -137 G/C polymorphisms with head and neck cancer risk: a comprehensive meta-analysis

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