Role of IL-8 gene polymorphisms in glioma development in a Chinese population

Abstract

ABSTRACT. This case-control study aimed to investigate the role of -251 T>A (rs4073) and -781 C>T (rs2227306) polymorphisms in the interleukin-8 (IL-8) gene in the development of glioma in a Chinese population. One hundred and twenty-seven glioma patients and 284 healthy control subjects were recruited to this study between February 2013 and December 2014. The IL-8 -251 T>A (rs4073) and -781 C>T (rs2227306) polymorphisms were genotyped by polymerase chain reaction coupled with restriction fragment length polymorphism. The patients and control subjects were comparable by gender (c 2 = 1.24, P = 0.27), tobacco smoking status (c 2 = 0.80, P = 0.37), alcohol consumption status (c 2 = 0.97, P = 0.32), and family history of cancer (c 2 = 1.54, P = 0.22). The age of glioma patients was statistically lower than that of control subjects (t = 2.87, P = 0.002). The chisquare test revealed the lack of any statistically significant differences in the genotype distributions of IL-8 rs4073 (c 2 = 0.89, P = 0.64) and rs2227306 (c 2 = 2.58, P = 0.28) between the glioma patients and control subjects. Unconditional logistic regression analysis revealed that the IL-8 rs4073 and rs2227306 gene polymorphisms did not contribute to the development of glioma. In conclusion, we determined that there is a lack of evidence suggesting a significant association between the IL-8 rs4073 and rs2227306 gene polymorphisms and the development of glioma in a Chinese population.

Extrinsic noise and heavy-tailed laws in gene expression

“…The standard Telegraph model for transcription describes the effect of intrinsic noise at the level of a single gene, yet the process will often also be influenced by other sources of variability. Such extrinsic noise has been widely observed experimentally Elowitz (2002); Swain et al (2002); Raser and O'Shea (2004); Gasch et al (2017), and considered theoretically Dattani and Barahona (2016); Fu and Pachter (2016); Bressloff and Levien (2019); Thomas (2019), but incorporating these effects into the Master equations has generally proven challenging. The approach we take in the context of the Telegraph model is to consider the model parameters themselves to vary between cells, and therefore to be drawn from probability distributions Lenive et al (2016).…”

Association of IL-6, IL-8, MMP-13 gene polymorphisms with knee osteoarthritis susceptibility in the Chinese Han population

“…Studies have reported that non-physiological mechanical stress caused by joint deformities can up-regulate the expression of interleukin (IL) 6 (IL-6), IL-8, and matrix metalloproteinase-13 (MMP-13) in the callus and is potentially involved in OA progression [9]. Single nucleotide polymorphisms (SNPs) in the genes encoding IL-6 [10], IL-8 [11], and MMP-13 [12] have been associated with the occurrence of various diseases. However, few studies have investigated the occurrence of OA.…”

Genetic regulation of IL-8 influences disease presentation of multiple sclerosis

“…SNP rs2227306 has been associated with worse clinical course in different inflammatory conditions. [30][31][32][33] T allelic variant of SNP rs2227306 has been associated with a higher risk of developing age-related wet macular degeneration, which is typically associated with increased intravitreal and retinal inflammation. 34 Notably, intravitreal levels of IL-8 are significantly increased in this condition, suggesting a possible role of SNP rs2227306 in regulating the secretion and function of this chemokine.…”