Contribution of Genetic Polymorphisms of Inflammation Response Genes on Sporadic Colorectal Cancer Predisposition Risk in Malaysian Patients – A Case Control Study

Ankathil, Ravindran; Mustapha, Mohd Aminudin; Aziz, Ahmad Aizat Abdul; Shahpudin, Siti Nurfatimah Mohd; Zakaria, Andee Dzulkarnaen; Hassan, Muhammad Radzi Abu; Musa, Kamarul Imran

doi:10.31557/apjcp.2019.20.6.1621

Cited by 5 publications

(3 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bondurant et al (14) reported that the SNP, rs4073, in IL-8 is associated with an increased CRC risk. Furthermore, another previous study involving Malaysian patients with CRC revealed that the homozygous variant of IL-8-251AA was associated with a higher susceptibility of CRC compared with the homozygous wild-type-251TT genotype (37). The IL-8-251T>A polymorphism has been reported to be associated with a higher promoter activity, which in turn increases the levels of IL-8 and promotes the proangiogenic effects of IL-8, and ultimately increases tumor cell proliferation (38).…”

Section: Discussionmentioning

confidence: 98%

Association between the serum concentrations and mutational status of IL‑8, IL‑27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer

2021

View full text Add to dashboard Cite

The present study aimed to determine the diagnostic value of the serum levels and mutational status of IL-8, IL-27 and VEGF, and the expression levels of human ether-a-go-go-related gene (hERG) in patients with colorectal cancer (CRC). The serum concentrations were determined using the ELISA technique and genotype variations of IL-8, IL-27 and VEGF were examined using Sanger sequencing, and the expression levels of hERG, which encodes a potassium channel, were determined by quantitative PCR, in blood and tissue samples obtained from 80 patients with CRC and 80 healthy individuals. The results of the present study revealed that the percentage of granulocytes and serum concentrations of carcinoembryonic antigen, IL-8 and IL-27 were significantly increased, whereas the percentage of lymphocytes was decreased in patients with CRC. In total, 31 mutations in three genes (eight mutations in VEGF, 13 mutations in IL-27 and 10 mutations in IL-8) were identified in patients with CRC. The relative mRNA expression levels of hERG were also significantly upregulated in tissue and blood samples of patients with CRC compared with those of healthy individuals. In conclusion, the results of the present study indicated that the increased concentrations and genetic variations of IL-8, IL-27 and VEGF may serve important roles in the development and angiogenic processes of CRC. These changes were concomitant with the upregulation of the expression levels of the potassium channel hERG.

show abstract

Section: Discussionmentioning

confidence: 98%

Association between the serum concentrations and mutational status of IL‑8, IL‑27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer

2021

View full text Add to dashboard Cite

show abstract

“…RDW reflects the heterogeneous parameters of red blood cell size and peripheral blood [ 14 , 15 ]. In addition, research shows that various factors will affect PLR and NLR individual test results and reduce sensitivity and specificity [ 16 ]. Therefore, PLR is carried out in patients with colorectal cancer, and NLR combination is very necessary.…”

Section: Discussionmentioning

confidence: 99%

Value Research of NLR, PLR, and RDW in Prognostic Assessment of Patients with Colorectal Cancer

Chen

Shen

2022

Journal of Healthcare Engineering

View full text Add to dashboard Cite

Objective. This study aimed to investigate the relevance of the study with the neutrophil count and lymphocyte count ratio (NLR), platelet count and lymphocyte count ratio (PLR), and red blood cell distribution width (RDW) in the prognostic evaluation of colorectal cancer patients. Methods. 143 patients with colorectal cancer from January 2016 to January 2019 were selected by our hospital, and then, other 143 cases of physical examiners as normal groups were selecting to proceed colonoscopic biopsy to diagnose 106 cases of precancerous diseases related to colorectal cancer. Among them were the inflammatory bowel group (n = 56) and the colorectal polyp group (n = 50). Analysis of the survival impact factors of patients with carcinoma of the rectum, preoperative NLR, ROW, PLR, and prognostic relationship, and comparison of NLR, PLR, and RDW diagnostic rate and expression were performed. Results. Tissue type, TNM stage, lymph node metastasis, NLR, RDW, and PLR had a predictive influence on patients with colorectal cancer ( P 0.05 ). There was no link between gender, age, aetiology, pathological type, and prognosis in patients with colorectal cancer ( P > 0.05 ). Multiple variables in patients with colorectal cancer are affected by tissue categorization (poor differentiation), TNM stages (III, IV), lymph node metastases, NLR, ROW, and PLR ( P 0.05 ). When compared to solo NLR, Row, and PLR diagnostics, the combination diagnosis and malignancy rates were greater, and the differences were statistically significant ( P 0.05 ). Diagnostic sensitivity, specificity, and accuracy were greater when compared to single NLR, ROW, and PLR. When compared to the normal control group, NLR, ROW, and PLR have greater levels, and the differences are statistically significant ( P 0.05 ). The patient survival declines more slowly as PLR, NLR, and the severity of the condition rises. Conclusion. NLR, ROW, and PLR combined diagnosis has high accuracy in colorectal cancer diagnosis, and the prognosis of patients with NLR, ROW, and PLR levels has a tight association; so, clinically, the above signs should be identified, and the optimal treatment time is grasped.

show abstract

“…Ravindran Ankathil et al. found that ICAM-1 rs5498 did not show significant association for CRC risk in Malaysian CRC patients ( 90 ). In our previous study, ICAM-1 rs3093030 polymorphism did not influence CRC risk ( 89 ).…”

Section: Icam-1 Single Nucleotide Polymorphisms In Crcmentioning

confidence: 99%

Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implications

et al. 2022

View full text Add to dashboard Cite

Colorectal cancer (CRC) is a major global health problem and one of the major causes of cancer-related death worldwide. It is very important to understand the pathogenesis of CRC for early diagnosis, prevention strategies and identification of new therapeutic targets. Intercellular adhesion molecule-1 (ICAM-1, CD54) displays an important role in the the pathogenesis of CRC. It is a cell surface glycoprotein of the immunoglobulin (Ig) superfamily and plays an essential role in cell-cell, cell-extracellular matrix interaction, cell signaling and immune process. It is also expressed by tumor cells and modulates their functions, including apoptosis, cell motility, invasion and angiogenesis. The interaction between ICAM-1 and its ligand may facilitate adhesion of tumor cells to the vascular endothelium and subsequently in the promotion of metastasis. ICAM-1 expression determines malignant potential of cancer. In this review, we will discuss the expression, function, prognosis, tumorigenesis, polymorphisms and therapeutic implications of ICAM-1 in CRC.

show abstract

Contribution of Genetic Polymorphisms of Inflammation Response Genes on Sporadic Colorectal Cancer Predisposition Risk in Malaysian Patients – A Case Control Study

Cited by 5 publications

References 59 publications

Association between the serum concentrations and mutational status of IL‑8, IL‑27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer

Association between the serum concentrations and mutational status of IL‑8, IL‑27 and VEGF and the expression levels of the hERG potassium channel gene in patients with colorectal cancer

Value Research of NLR, PLR, and RDW in Prognostic Assessment of Patients with Colorectal Cancer

Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implications

Contact Info

Product

Resources

About