Use of a Lower Cut-Off Value for HbA1c to Predict Postoperative Renal Complication Risk in Patients Undergoing Coronary Artery Bypass Grafting

Gümüş, Funda; Polat, Adil; Sınıkoglu, Sıtkı Nadir; Yektaş, Abdülkadir; Kerem, Eitan; Alagöl, Ayşin

doi:10.1053/j.jvca.2013.02.030

Cited by 22 publications

(25 citation statements)

References 20 publications

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“…Halkos et al [30] found that HbA 1c levels greater than 7% were associated with renal failure. Additionally, Gumus et al [9] found that elevated levels of HbA 1c were associated with increased renal complications. Likewise, in our study, a relationship was found between high preoperative creatinine, BUN, HbA 1c levels and occurrence of postoperative AKI in our study.…”

Section: Discussionmentioning

confidence: 99%

“…HbA 1c levels were found to be related to cardiovascular and renal complications following open heart surgery [9] . Multiple factors have been implicated as contributors to postoperative AKI, including advanced age, female gender, presence of diabetes mellitus, chronic kidney disease, extended time between heart catheterization and surgery, aortic cross clamp time, duration of cardiopulmonary bypass (CPB), and blood transfusion following surgery [6] .…”

Section: Introductionmentioning

confidence: 99%

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Hemoglobin A1c Levels Predicts Acute Kidney Injury after Coronary Artery Bypass Surgery in Non-Diabetic Patients

Koçoğulları

Kunt²,

Aksoy

et al. 2017

Braz J Cardiovasc Surg

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Introduction Elevated hemoglobin A1c levels in patients with diabetes mellitus have been known as a risk factor for acute kidney injury after coronary artery bypass grafting. However, the relationship between hemoglobin A1c levels in non-diabetics and acute kidney injury is under debate. We aimed to investigate the association of preoperative hemoglobin A1c levels with acute kidney injury in non-diabetic patients undergoing isolated coronary artery bypass grafting.Methods202 non-diabetic patients with normal renal function (serum creatinine <1.4 mg/dl) who underwent isolated coronary bypass were analyzed. Hemoglobin A1c level was measured at the baseline examination. Patients were separated into two groups according to preoperative Hemoglobin A1c level. Group 1 consisted of patients with preoperative HbA1c levels of < 5.6% and Group 2 consisted of patients with preoperative HbA1c levels of ≥ 5.6%. Acute kidney injury diagnosis was made by comparing baseline and postoperative serum creatinine to determine the presence of predefined significant change based on the Kidney Disease Improving Global Outcomes (KDIGO) definition.ResultsAcute kidney injury occurred in 19 (10.5%) patients after surgery. The incidence of acute kidney injury was 3.6% in Group 1 and 16.7% in Group 2. Elevated baseline hemoglobin A1c level was found to be associated with acute kidney injury (P=0.0001). None of the patients became hemodialysis dependent. The cut off value for acute kidney injury in our group of patients was 5.75%.ConclusionOur findings suggest that, in non-diabetics, elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients undergoing coronary artery bypass grafting. Prospective randomized studies in larger groups are needed to confirm these results.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hemoglobin A1c Levels Predicts Acute Kidney Injury after Coronary Artery Bypass Surgery in Non-Diabetic Patients

Koçoğulları

Kunt²,

Aksoy

et al. 2017

Braz J Cardiovasc Surg

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show abstract

“…Our findings have been corroborated by other studies. Elevated HbA1c has been reported to be associated with increased early mortality rates, adverse postoperative outcomes, and shorter long-term survival [3,4,13,[16][17][18]. Rates of deep [3] as well as superficial [19] sternal wound infections were significantly increased with a higher HbA1c.…”

Section: Commentmentioning

confidence: 97%

Preoperative Glycosylated Hemoglobin: A Risk Factor for Patients Undergoing Coronary Artery Bypass

Narayan

Kshirsagar

Mandal

et al. 2017

The Annals of Thoracic Surgery

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“…Chronic renal dysfunction (CRD) denoted the patients who had serum creatinine levels above the normal (0.5-1.3 mg/dL [44-115 mmol/L]) range. 4 The pulmonary function of the patients was evaluated with spirometry preoperatively. As a result of the spirometry, the values for forced vital capacity (FVC), forced expiratory volume in 1 second (FEV 1 ), and FVC/FEV 1 ratio were obtained.…”

Section: Definitionsmentioning

confidence: 99%

Prolonged Mechanical Ventilation After CABG: Risk Factor Analysis

Gümüş

Polat

Yektaş

et al. 2015

Journal of Cardiothoracic and Vascular Anesthesia

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Use of a Lower Cut-Off Value for HbA1c to Predict Postoperative Renal Complication Risk in Patients Undergoing Coronary Artery Bypass Grafting

Cited by 22 publications

References 20 publications

Hemoglobin A1c Levels Predicts Acute Kidney Injury after Coronary Artery Bypass Surgery in Non-Diabetic Patients

Hemoglobin A1c Levels Predicts Acute Kidney Injury after Coronary Artery Bypass Surgery in Non-Diabetic Patients

Preoperative Glycosylated Hemoglobin: A Risk Factor for Patients Undergoing Coronary Artery Bypass

Prolonged Mechanical Ventilation After CABG: Risk Factor Analysis

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