Basaloid squamous cell carcinoma of the oral cavity: An analysis of 92 cases

Fritsch, Valerie A.; Gerry, Daniel; Lentsch, Eric J.

doi:10.1002/lary.24384

Cited by 36 publications

(25 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present literature review based on 119 oral BSCCs revealed essentially similar overall presentation as previously reported and could be considered as a tumor of old age occurring predominantly in men and showing a predilection to the tongue and floor of the mouth (Table 2) [17]. Furthermore, it could also be characterized as a tumor showing an aggressive clinical course, with approximately half of the patients developing local metastasis and slightly more than half the patients dying of the disease (Table 2).…”

Section: Discussionsupporting

confidence: 75%

“…Separating purely oral cavity BSCCs from oropharyngeal tumors was also problematic because lesions occurring at the base of the tongue and palate were considered as belonging to the oropharynx by some, whereas others have included these tumors as arising from the oral cavity [32,33]. However, subsequently, a review article based on 92 cases of purely oral BSCCs was also identified [17]. Most findings of this study corresponded with the findings of the present study, except for the commonest site of occurrence.…”

Section: Discussionsupporting

confidence: 71%

“…Basaloid squamous cell carcinoma is considered as a tumor that predominantly arises in elderly men. In addition, these tumors have been identified in numerous head and neck sites including oral cavity [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18], oropharynx [1,6,[19][20][21][22][23], hypopharynx [16,[24][25][26], esophagus [27][28][29], and sinonasal region [30]. Basaloid squamous cell carcinomas are also considered as more aggressive tumors showing a poorer survival compared with squamous cell carcinoma by some authors [15,21,31], whereas others disagree with this observation [12,16,18,27].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A literature review on oral basaloid squamous cell carcinomas, with special emphasis on etiology

Jayasooriya

Tilakaratne

Mendis

et al. 2013

Annals of Diagnostic Pathology

View full text Add to dashboard Cite

a b s t r a c t a r t i c l e i n f o Keywords: Basaloid squamous cell carcinoma Human papillomavirus Etiology PrognosisIn the recent years, basaloid squamous cell carcinomas (BSCCs) have gained attention because of (1) observation of a relative increase in the number of tumors arising particularly in head and neck sites, (2) identification of human papillomavirus (HPV) in BSCCs arising predominantly in the oropharynx, and (3) controversies that exist regarding the biological aggressiveness of the tumor. The objective of the present review was to address the issues mentioned above by focusing primarily on oral BSCCs, using literature that has been published in the English language up to 2013. According to the literature review, oral BSCCs were found to be relatively more common in elderly patients with a mean age of 64 years. A male predominance with a male/female ratio of 3:1 was observed. The predominant site was the tongue, with almost half of the reported cases occurring at this site, followed by the floor of the mouth and palate. With reference to habit history, majority were found to be tobacco and alcohol users. However, only 3 studies revealed data on HPV status of purely oral BSCC, and according to the results of these studies, of the 17 tumors tested, 4 had harbored high-risk HPV. Furthermore, most oral BSCCs were in an advanced clinical stage, namely, stage III or IV with T3 or T4 lesions and cervical lymph node metastasis at initial presentation, whereas 41% of patients had presented with local recurrences and 45% had died of the disease. In conclusion, although, the present literature review found enough evidence to consider tobacco and alcohol as risk factors for the development of oral BSCC, steps should be taken to fill the gap in our knowledge that exist with reference to contribution of oncoviruses, particularly HPV in the etiology of oral BSCC.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A literature review on oral basaloid squamous cell carcinomas, with special emphasis on etiology

Jayasooriya

Tilakaratne

Mendis

et al. 2013

Annals of Diagnostic Pathology

View full text Add to dashboard Cite

show abstract

“…Prognostically, it is important to distinguish between BCC and BSC.In majority of cases, BSC has been diagnosed on biopsy and histopathological features have been discussed in detail. [1][2][3][4][5] The cytological features have not been discussed much before. To the best of our knowledge, this is the first case report discussing the characteristic cytological features of this rare entity.…”

Section: Discussionmentioning

confidence: 99%

“…Histopathological features of this rare entity have been well discussed in literature. [1][2][3][4][5] But there is scarcity of information on the cytological features of BSC. We have not come across a single case in literature discussing the cytological features of BSC.To the best of our knowledge, this is the first case report discussing the characteristic cytological features of BSC which helped us to clinch the diagnosis.…”

Section: Introductionmentioning

confidence: 99%