Using the SEER database, we report what we believe to be the largest head and neck MCC study to date. Our results suggest that sentinel lymph node status does not predict survival in head and neck MCC. Independent predictors of MCC-related mortality seem to be unique in the head and neck region.

Analysis of the largest laryngeal BSCC series to date (n = 145) demonstrates that BSCC carries a worse prognosis than conventional SCC of the larynx.

SpCC of the head and neck is more likely than SCC to present at an early stage, with fewer nodal metastases. Survival rates appear to depend on anatomic site as well.

BSCC's propensity for advanced-stage presentation was confirmed in this study. However, BSCC appears to carry a paradoxically similar, or better, prognosis compared to conventional-type SCC in most cases.