Question 1: In a child with epilepsy, does melatonin affect the seizure threshold?

Banerjee, Somnath; Kumar, Vinod

doi:10.1136/archdischild-2013-304036

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…The best evidence indicates that melatonin improves sleep and appears safe in children with epilepsy, and may possibly have a positive impact on seizure control. 27 Clinical trials are needed to better evaluate the impact of melatonin therapy on children with epilepsy.…”

Section: Herbs and Other Alternative Therapiesmentioning

confidence: 99%

Options for Pharmacoresistant Epilepsy in Children: When Medications Don’t Work

Sharp¹,

Samanta²,

Willis³

2015

Pediatr Ann

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Medications are often first-line treatment for epilepsy in children. A detailed review of antiepileptic drugs and their application in various epilepsy syndromes is provided in the article "Antiepileptic Drugs--A Review" by Sankaraneni and Lachhwani (this issue). Here, we will focus on nonmedicinal approaches-some fairly longstanding and described since Biblical times such as the ketogenic diet while others are relatively new such as neurostimulation. Yet, others such as cannabinoids have been utilized for centuries for their medicinal properties, but we are just learning the scientific basis behind their efficacy. Families are often interested in nonmedicinal avenues of treatment, and knowledge of these options can empower a pediatrician to help families make choices that have scientific validity.

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Section: Herbs and Other Alternative Therapiesmentioning

confidence: 99%

Options for Pharmacoresistant Epilepsy in Children: When Medications Don’t Work

Sharp¹,

Samanta²,

Willis³

2015

Pediatr Ann

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Comparison Between Efficacy of Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures: A Randomized Clinical Trial

Barghout

Alshahawy

Amrousy

et al. 2019

Pediatric Neurology

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The role of melatonin and its analogues in epilepsy

Khan

Khurana

Vyas

et al. 2020

Reviews in the Neurosciences

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Extensive research has gone into proposing a promising link between melatonin administration and attenuation of epileptic activity, the majority of which suggest its propensity as an antiseizure with antioxidant and neuroprotective properties. In the past few years, a number of studies highlighting the association of the melatonergic ligands with epilepsy have also emerged. In this context, our review is based on discussing the recent studies and various mechanisms of action that the said category of drugs exhibit in the context of being therapeutically viable antiseizure drugs. Our search revealed several articles on the four major drugs i.e. melatonin, agomelatine, ramelteon and piromelatine along with other melatonergic agonists like tasimelteon and TIK-301. Our review is suggestive of antiseizure effects of both melatonin and its analogues; however, extensive research work is still required to study their implications in the treatment of persons with epilepsy. Further evaluation of melatonergic signaling pathways and mechanisms may prove to be helpful in the near future and might prove to be a significant advance in the field of epileptology.

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Question 1: In a child with epilepsy, does melatonin affect the seizure threshold?

Cited by 3 publications

References 12 publications

Options for Pharmacoresistant Epilepsy in Children: When Medications Don’t Work

Options for Pharmacoresistant Epilepsy in Children: When Medications Don’t Work

Comparison Between Efficacy of Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures: A Randomized Clinical Trial

The role of melatonin and its analogues in epilepsy

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