Comparison Between Efficacy of Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures: A Randomized Clinical Trial

Barghout, M.; Alshahawy, Azza Kamal; Amrousy, Doaa El; Darwish, Amira Hamed

doi:10.1016/j.pediatrneurol.2019.01.010

Cited by 8 publications

(3 citation statements)

References 23 publications

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“…Several relatively small studies have evaluated the intermittent and chronic use of the antiseizure medications valproate and levetiracetam, as well as pyridoxine, melatonin, and zinc sulfate to prevent febrile seizures. 81 , 82 , 83 , 84 , 85 , 86 Although these studies demonstrated some marginal success at febrile seizure prevention, a 2021 Cochrane systematic review concluded there is currently insufficient evidence to support the use of these agents for this purpose. 87 Clearly, more research is needed in this area.…”

Section: Future Considerationsmentioning

confidence: 99%

Febrile seizures: A review

Eilbert

Chan

2022

JACEP Open

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Febrile seizures are common, occurring in up to 5% of children in the United States. Frequently perceived by caregivers as a life‐threatening event, febrile seizures are a common cause of emergency department visits. The concern for permanent neurologic sequelae and future epilepsy after febrile seizures has resulted in a significant amount of research on these topics. The development of childhood vaccines over the past several decades has led to a significant reduction in childhood bacterial meningitis. This in turn has led to a dramatic change in the evaluation and treatment of febrile seizures. In this review, the different types of febrile seizures as well as the evaluation and prognosis of each are discussed.

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Section: Future Considerationsmentioning

confidence: 99%

Febrile seizures: A review

Eilbert

Chan

2022

JACEP Open

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“…Both melatonin and diazepam were given only during febrile illness, and patients were followed up for 6 months. Both melatonin and diazepam significantly reduced the recurrence of febrile seizures without significant differences between the two groups ( 31 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of melatonin on sleep quality and EEG features in childhood epilepsy: a possible non-conventional treatment

Dell'Isola,

Tascini,

Vinti

et al. 2023

Front. Neurol.

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BackgroundSleep and epilepsy are characterized by a bidirectional relationship. Indeed, epilepsy predisposes to the development of sleep disorders, while sleep deprivation may exacerbate epilepsy. In addition, antiseizure medication can disrupt normal sleep architecture. Therefore, adequate sleep hygiene could lead to improvement in seizure control. The present study aimed to evaluate the effect of melatonin on seizure frequency, EEG tracing, and sleep in children with focal idiopathic epilepsy.MethodsThis observation study evaluated the effect of 4 mg oral melatonin in ameliorating sleep–wake cycle, seizure frequency, and EEG features in children with focal idiopathic epilepsy of infancy. Twenty children were enrolled from September 2020 to August 2021. The study consisted of serial controls at enrollment (t0), at 3 months (t1), and at 6 months (t2) including neurological examination, questionnaire about sleep disturbances (CSHQ), and EEG.ResultsA significant improvement in sleep quality and daytime sleepiness was observed after melatonin supplementation. Furthermore, we observed a noteworthy improvement in EEG tracing at t2 that exhibited a significant correlation with improvements in CSHQ scores.ConclusionThe studies conducted so far to evaluate the effect of melatonin in persons with epilepsy do not lead to definitive conclusions. Despite the small population sample and the study design, we report sleep and EEG improvement after melatonin administration in our cohort. Larger studies are needed to further study the neuroprotective and anticonvulsant properties of melatonin.

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“…It can be used for the treatment of children with developmental disorders, such as ASD and attention deficit/hyperactivity disorder to improve their sleep disturbance ( 11 , 12 ). Animal experiments and limited human data have confirmed the neuroprotective effect of melatonin on hypoxic-ischemic (HI) or developmental seizure-induced excitotoxic brain damage ( 13 – 15 ). Here, two studies have explored the molecular signaling mechanism of the neuroprotective effect of melatonin through the in vitro glutamate excitotoxic injury model and the in vivo cerebral palsy model.…”

Section: Introductionmentioning

confidence: 99%