Detection of low level microwave radiation induced deoxyribonucleic acid damage vis-à-vis genotoxicity in brain of fischer rats

Deshmukh, Pravin Suryakantrao; Megha, Kanu; Banerjee, Basu Dev; Ahmed, Rafat S.; Chandna, Sudhir; Abegaonkar, Mahesh P.; Tripathi, Anil Kumar

doi:10.4103/0971-6580.111549

Cited by 32 publications

(8 citation statements)

References 31 publications

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“…The brain has a high metabolic rate, making it more prone to damage by ROS and oxidative damage compared to other organs [ 69 ]. Excessive amounts of ROS in tissues may lead to necrosis, the death of neurons and neuronal damage in brain tissue, as well as to neurological disorders such as Alzheimer’s disease, spinal cord injury, multiple sclerosis, and epilepsy [ 70 ] ( Fig. 2 ).…”

Section: Emf-related Oxidative Stress and Effects On Tissuementioning

confidence: 99%

Effects of electromagnetic fields exposure on the antioxidant defense system

Kıvrak

Yurt

Kaplan

et al. 2017

J Microsc Ultrastruct

184

113

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Technological devices have become essential components of daily life. However, their deleterious effects on the body, particularly on the nervous system, are well known. Electromagnetic fields (EMF) have various chemical effects, including causing deterioration in large molecules in cells and imbalance in ionic equilibrium. Despite being essential for life, oxygen molecules can lead to the generation of hazardous by-products, known as reactive oxygen species (ROS), during biological reactions. These reactive oxygen species can damage cellular components such as proteins, lipids and DNA. Antioxidant defense systems exist in order to keep free radical formation under control and to prevent their harmful effects on the biological system. Free radical formation can take place in various ways, including ultraviolet light, drugs, lipid oxidation, immunological reactions, radiation, stress, smoking, alcohol and biochemical redox reactions. Oxidative stress occurs if the antioxidant defense system is unable to prevent the harmful effects of free radicals. Several studies have reported that exposure to EMF results in oxidative stress in many tissues of the body. Exposure to EMF is known to increase free radical concentrations and traceability and can affect the radical couple recombination. The purpose of this review was to highlight the impact of oxidative stress on antioxidant systems.Abbreviations: EMF, electromagnetic fields; RF, radiofrequency; ROS, reactive oxygen species; GSH, glutathione; GPx, glutathione peroxidase; GR, glutathione reductase; GST, glutathione S-transferase; CAT, catalase; SOD, superoxide dismutase; HSP, heat shock protein; EMF/RFR, electromagnetic frequency and radiofrequency exposures; ELF-EMFs, exposure to extremely low frequency; MEL, melatonin; FA, folic acid; MDA, malondialdehyde.

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Section: Emf-related Oxidative Stress and Effects On Tissuementioning

confidence: 99%

Effects of electromagnetic fields exposure on the antioxidant defense system

Kıvrak

Yurt

Kaplan

et al. 2017

J Microsc Ultrastruct

184

113

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“…Previous investigations indicated that radiations can induce several damages at DNA level (20), changes in the structure and functions of plasma membrane [i.e., NADH (nicotinamide adenine dinucleotide) oxidase and phosphatidylserine] (21), Ca 2+ signaling and NMDA (Nmethyl-d-aspartic acid) receptor functions (22), voltagegated calcium channels (23), and oxidative stress (10). These changes could cause cellular and organ dysfunctions.…”

Section: Ionizing /Non-ionizing Radiation and Cell Functionmentioning

confidence: 99%

“…Components of heredity substances of eukaryote cells are susceptible to oxidative damages; pyrimidines are more susceptible to oxidative damages than purines and Various studies showed that exposure to ionizing radiation directly and indirectly via generating singlet oxygen, induce lesions in cellular DNA through deletions, mutations and other lethal genetic effects (20). The 8-hydroxy-2-deoxyguanosine (8-OH-2-deoxyguianosine) is a common byproduct of DNA oxidation considered as a key biomarker of oxidative DNA damage (35).…”

Section: Radiation Ros and Dna Damagementioning

confidence: 99%

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Oxidative Stress as the Underlying Biomechanism of Detrimental Outcomes of Ionizing and Non-Ionizing Radiation on Human Health: Antioxidant Protective Strategies

Akbari

Jelodar

Nazifi

et al. 2019

Zahedan J Res Med Sci

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Context: The deleterious effects of ionizing and non-ionizing radiations occur through non-thermal and thermal effects. Thermal effects occur particularly at long wavelength radiations with heating properties and increase temperature of the tissue. The non-thermal effects are due to the changes in structure and functions of cell membrane, genetic effects, extracellular /intracellular signaling pathways, and oxidative stress. Objectives: Oxidative stress referring to overproduction of reactive oxygen species (ROS) and /or deficiency in antioxidant defense mechanisms acts like a double-edged sword. Therefore, modification of endogenous antioxidants activity and production of ROS have a significant role in controlling such conditions. Methods: The current review study focused on the effects of oxidative stress after exposure to ionizing and non-ionizing radiations on cell functions and antioxidant defense. Results: The results of many studies suggested that exposure to both ionizing and non-ionizing radiations (e.g., radiofrequency electromagnetic fields emitted from mobile phones and other wireless technologies) may activate oxidizing events, which transform the atomic structure and change macromolecules structures such as proteins, lipids, and DNA. Conclusions: It can be concluded that physiological responses of cells to injurious stimuli by changes in ROS production cause impairment of cell functions via oxidative damage, and also cause a physiological phenomenon known as adaptive response. In fact, rate of ROS production, redox state of the cell, previous exposures to harmful agents along with other factors contribute to the prevalence of each of such responses.

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“…There is growing serious concern that the exponentially increased exposure to RF-EMF from mobile phones might lead to adverse health effects [ 30 ]. Cell phones are popular communication devices that emit low levels of RF-EMF.…”

Section: Introductionmentioning

confidence: 99%

Looking at the other side of the coin: the search for possible biopositive cognitive effects of the exposure to 900 MHz GSM mobile phone radiofrequency radiation

Mortazavi

Tavakkoli-Golpayegani²,

Haghani

et al. 2014

J Environ Health Sci Engineer

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Although exposure to electromagnetic radiation in radiofrequency range has caused a great deal of concern globally, radiofrequency radiation has many critical applications in both telecommunication and non-communication fields. The induction of adaptive response phenomena by exposure to radiofrequency radiation as either increased resistance to a subsequent dose of ionizing radiation or resistance to a bacterial infection has been reported recently. Interestingly, the potential beneficial effects of mobile phone radiofrequency radiation are not only limited to the induction of adaptive phenomena. It has previously been indicated that the visual reaction time of university students significantly decreased after a 10 min exposure to radiofrequency radiation emitted by a mobile phone. Furthermore, it has been revealed that occupational exposures to radar radiations decreased the reaction time in radar workers. Based on these findings, it can be hypothesized that in special circumstances, these exposures might lead to a better response of humans to different hazards. Other investigators have also provided evidence that confirms the induction of RF-induced cognitive benefits. Furthermore, some recent reports have indicated that RF radiation may play a role in protecting against cognitive impairment in Alzheimer’s disease. In this light, a challenging issue will arise if there are other RF-induced stimulating effects. It is also challenging to explore the potential applications of these effects. Further research may shed light on dark areas of the health effects of short and long-term human exposure to radiofrequency radiation.

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Detection of low level microwave radiation induced deoxyribonucleic acid damage vis-à-vis genotoxicity in brain of fischer rats

Cited by 32 publications

References 31 publications

Effects of electromagnetic fields exposure on the antioxidant defense system

Effects of electromagnetic fields exposure on the antioxidant defense system

Oxidative Stress as the Underlying Biomechanism of Detrimental Outcomes of Ionizing and Non-Ionizing Radiation on Human Health: Antioxidant Protective Strategies

Looking at the other side of the coin: the search for possible biopositive cognitive effects of the exposure to 900 MHz GSM mobile phone radiofrequency radiation

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