Keratocystic odontogenic tumor: A retrospective analysis of genetic, immunohistochemical and therapeutic features. Proposal of a multicenter clinical survey tool

Finkelstein, Michael W.; Hellstein, John W.; Lake, Kimberly S.; Vincent, Steven D.

doi:10.1016/j.oooo.2013.03.018

Cited by 24 publications

(28 citation statements)

References 49 publications

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“…KCOT-3 cells secreted active MMP-2 as determined by a gel zymography assay. Expression of 2,3, 11, 12, 14, and 16 was confirmed in matching primary KCOT tumor sections representing syndromic and nonsyndromic KCOTs. Conclusion: KCOT primary cell populations and tumors express a wide range of MMPs, which likely play a role in the bone-invasive nature of these tumors.…”

mentioning

confidence: 78%

“…Roles attributed to MMPs in tumor development include regulation of tumor growth by mediating the release of stimulating growth factors into the tumor microenviroment (e.g. insulin-like growth factors, epidermal growth factor receptor ligands; MMP-1, 2, 3,7,9,11,19), promoting angiogenesis by degrading the extracellular matrix and increasing availability to vascular endothelial growth factor (MMP-1, 2, 7, 9, and 14) and supporting cell migration and invasion by promoting epithelial-to-mesenchymal transition allowing cells to decrease cell-cell adhesion (MMP-2, 3, 9, 13, 14). Of these MMPs Earlier studies have identified the expression of MMP-1, 2, 9, 13, and 26 in some KCOTs.…”

Section: Discussionmentioning

confidence: 99%

“…They are invasive within the maxilla or mandible and are reported to recur at the primary site depending on the form of surgical treatment used (3-60%) (3). KCOTs can occur as nonsyndromic, sporadic cases or associated with Nevoid basal cell carcinoma syndrome (NBCCS, also known as Gorlin's syndrome).…”

Section: Introductionmentioning

confidence: 99%

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Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells

Amm

Casimir

Clark

et al. 2014

Connective Tissue Research

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mentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells

Amm

Casimir

Clark

et al. 2014

Connective Tissue Research

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“…The basal layer of cuboidal to columnar cells with hyperchromatic and palisaded nuclei is observed. The connective tissue wall may be containing epithelial islands or daughter cyst, and some cases may have acute or chronic inflammation (25).…”

Section: Odontogenin Keratocystmentioning

confidence: 99%

“…In contrast to endodontic lesion, the conservative treatment of OKC is enucleation and curettage. Due to high rates of recurrence, the patient with this lesion should be followed up after five years of treatment (25,28).…”

Section: Odontogenin Keratocystmentioning

confidence: 99%

Periapical Lesions: a Review of Clinical, Radiographic, and Histopathologic Features

Razavi¹,

Kiani²,

Khalesi³

2015

Avicenna J Dent Res

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Context:The essential role of a general dental practitioner is recognizing the nature of the oral cavity lesions. Periapical lesions, which are observed in radiographs of patients, may have odontogenic or nonodontogenic origins. This review aimed to study differential diagnosis of common and important periapical lesions. Evidence Acquisition: English-language literature were searched by manual and electronic search with the terms "periapical lesions", "jaw neoplasms", and "non-odontogenic lesions" in three data bases of MEDLINE, Google scholar, and SCOPUS among published studies since 2000 to 2013. All review articles, original articles, case reports, and case series were evaluated. Results: In this study, it has been showed that many periapical lesions have not endodontic origin and not healing by root canal therapy. Conclusions:The authors recommended to have paraclinical tests, especially vitality tests, in addition to clinical and radiographic examinations to avoid endodontic mistreatment. In suspicious cases, biopsy of lesions, referral to pathologist, and long-term fallow-up is required.

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Investigation of clinicopathological parameters and expression of COX-2, bcl-2, PCNA, and p53 in primary and recurrent sporadic odontogenic keratocysts

et al. 2018

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ObjectivesOdontogenic keratocyst (OKC) presents considerable variation in aggressiveness and propensity for recurrence, yet hitherto, no explicit clinicopathological features have been determined to clearly demonstrate the potential for relapse. This retrospective study aims to investigate the prognostic relevance of various clinicopathological features as well as immunoexpression of COX-2, bcl-2, PCNA, and p53 in sporadic OKC.Materials and methodsAmong 41 patients with OKC treated by enucleation, the frequency of recurrence for various clinicopathological features as well as immunoexpression for COX-2, bcl-2, PCNA, and p53 was evaluated.ResultsThe mean follow-up was 8.49 years, and recurrences were ascertained in 29.27% of cases. We found significant differences between recurrent and non-recurrent cysts in terms of multilocularity (P = 0.029), cortical perforation (P = 0.001), and lesion size (P < 0.001). Hazard risk for the recurrence was 3.362 (95% CI 1.066–10.598) for multilocular cysts, 7.801 (95% CI 2.1–28.985) for evidence of cortical perforation, and 1.004 (1.002–1.006) for 1 mm2 of lesion size on panoramic radiographs. We also found that immunoexpression of PCNA significantly correlates with the radiographic evidence of cortical perforation (P = 0.048) and that there is significant positive correlation between expression of COX-2 and bcl-2 (P = 0.001) as well as significant negative correlation between immunoexpression of COX-2 and age (P = 0.002). None of the other analyzed factors were associated with the recurrence.ConclusionsLarger size, multilocularity, and cortical perforation in sporadic OKC may be correlated with the relapse.Clinical relevanceImmunohistochemical analyses of COX-2, bcl-2, PCNA, and p53 lack prognostic utility in sporadic OKC.

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Keratocystic odontogenic tumor: A retrospective analysis of genetic, immunohistochemical and therapeutic features. Proposal of a multicenter clinical survey tool

Cited by 24 publications

References 49 publications

Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells

Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells

Periapical Lesions: a Review of Clinical, Radiographic, and Histopathologic Features

Investigation of clinicopathological parameters and expression of COX-2, bcl-2, PCNA, and p53 in primary and recurrent sporadic odontogenic keratocysts

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