Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells

Amm, Hope M.; Casimir, Monee D; Clark, Dakota B; Sohn, Phillip; MacDougall, Mary

doi:10.3109/03008207.2014.923875

Cited by 11 publications

(12 citation statements)

References 10 publications

(24 reference statements)

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“…They are thought to play a role in the locally invasive nature of odontogenic tumors. Many studies have shown the expression of various MMPs in odontogenic tumors, including ameloblastomas and KCOT [48, 51, 55–57]. Treating AME-HPV cells with EGF induced increased expression of MMP-2 and MMP-9, and increased the rates of invasion and migration of these cells [54].…”

Section: Epidermal Growth Factor Receptor (Egfr)mentioning

confidence: 99%

Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis

Amm

MacDougall

2016

Curr Oral Health Rep

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Several molecular pathways have been shown to play critical roles in the pathogenesis of odontogenic tumors. These neoplasms arise from the epithelial or mesenchymal cells of the dental apparatus in the jaw or oral mucosa. Next generation genomic sequencing has identified gene mutations or single nucleotide polymorphisms associated with many of these tumors. In this review, we focus on two of the most common odontogenic tumor subtypes: ameloblastoma and keratocystic odontogenic tumors. We highlight gene expression and protein immunohistological findings and known genetic alterations in the hedgehog, BRAF/Ras/MAPK, epidermal growth factor receptor, Wnt and Akt signaling pathways relevant to these tumors. These various pathways are explored to potentially target odontogenic tumors cells and prevent growth and recurrence of disease. Through an understanding of these signaling pathways and their crosstalk, molecular diagnostics may emerge as well as the ability to exploit identified molecular differences to develop novel molecular therapeutics for the treatment of odontogenic tumors.

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Section: Epidermal Growth Factor Receptor (Egfr)mentioning

confidence: 99%

Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis

Amm

MacDougall

2016

Curr Oral Health Rep

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“…38,39 MMPs have been detected in both cyst fluids and wall tissue extracts of various odontogenic cysts and odontogenic tumors, including ABs, suggesting that these enzymes play a key role in regulation of tumor and cyst growth. [40][41][42][43] In the present research, the expression of MMP in AB and its effect on tumor cell invasion and the prognosis of patients were varied. Thus, identification of prognostic values of the MMPs in ABs is of considerable importance to determine the most appropriate therapeutic approach and establish the prognosis of patient.…”

Section: Discussionmentioning

confidence: 83%

Expression of Matrix Metalloproteinases in Ameloblastomas and Ameloblastic Carcinoma: Systematic Review and Meta-analysis

Yongmei¹,

Zhong²,

Ye³

et al. 2019

Exploratory Research and Hypothesis in Medicine

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Objective: This study aimed to examine the difference in expression of matrix metalloproteinases (MMPs) in ameloblastoma and other benign tumors or normal tissue of the jaw, and ameloblastic carcinoma, and to investigate the correlation of expression of MMPs with patient prognosis. Methods: Studies were identified in the major electronic databases (Medline, EMBASE and Cochrane Library) using the keywords "matrix metalloproteinases" and "ameloblastoma" OR "ameloblastic carcinoma", and a quantitative meta-analysis was conducted. Results: Fourteen studies were included in this systematic review. Twelve studies representing a total number of 471 cases qualified for the meta-analysis. The analysis revealed a higher MMP-2 expression in ameloblastoma than in the other benign odontogenic tumors, showing a significant inter-group difference (odds ratio [OR]: 5.33; 95% confidence interval (CI): [1.36, 25.62]; p = 0.02). A lower MMP-2 expression was found for the ameloblastoma than in the ameloblastic carcinoma, with a non-significant inter-group difference (OR: 0.12; 95% CI: [0.01, 1.02]; p = 0.05). Finally, a lower MMP-9 expression was found for the follicular subgroup compared to that in other subgroups of ameloblastoma, showing a significant inter-group difference (OR: 0.15; 95% CI: [0.05, 0.48]; p = 0.001). Conclusions: We found that MMP-2 expression in ameloblastoma is higher than that in other benign tumors or normal tissue of jaw, and that MMP-9 expression in the follicular subgroup of ameloblastoma is lower than that in other pathology subgroups of ameloblastoma. What is more important, the MMPs expression in ameloblastoma was found to be significantly correlated with many clinicopathologic features of ameloblastoma. However, some limitations weakened the power of this meta-analysis.

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“…Because MMP2 and MMP-9 can degrade bone matrix and in turn release mitogenic factors to enhance tumor cell proliferation, MMP2 and MMP-9 may play an important role in the local invasiveness of ameloblastomas (10). For KCOTs, the MMP-2 expression is found in all examined samples and in the basal cells and basement membrane zone of the detached lining epithelium (11). Furthermore, the active form of MMP-9 is frequently detected in KCOTs (12).…”

Section: Discussionmentioning

confidence: 95%

Expression of astrocyte elevated gene‐1 protein in ameloblastomas, keratocystic odontogenic tumors, and dentigerous cysts

Chang

Tseng

et al. 2016

J Oral Pathology Medicine

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Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells

Abstract: KCOT primary cell populations and tumors express a wide range of MMPs, which likely play a role in the bone-invasive nature of these tumors.

Cited by 11 publications

References 10 publications

Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis

Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis

Expression of Matrix Metalloproteinases in Ameloblastomas and Ameloblastic Carcinoma: Systematic Review and Meta-analysis

Expression of astrocyte elevated gene‐1 protein in ameloblastomas, keratocystic odontogenic tumors, and dentigerous cysts

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