Hépatite cholestatique sévère révélant un Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome

Droz, Nina; Thiébaut, Michel; Terrier, B.; Bérezné, Alice; Sogni, Philippe; Beuvon, Frédéric; Guillevin, Loı̈c; Mouthon, Luc

doi:10.1016/j.revmed.2013.02.034

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…Pure anicteric cholestasis is rarer. Any impairment of hepatic function with decrease in rate of Prothrombin is a sign of severity and can be deadly at times [5]. For both of our patients, hepatic impairment was constant.…”

Section: Issn: 2689-4610mentioning

confidence: 55%

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Dress Syndrome Induced by Antiepileptic Drugs in Hospitals in Bukavu: About Two Cases

Semikenke¹

2018

JOJDC

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Section: Issn: 2689-4610mentioning

confidence: 55%

“…The most visceral impact is hepatic impairment. It is also the main cause of mortality [4][5][6]. Cytolysis is also found that in 80% of the cases.…”

Section: Issn: 2689-4610mentioning

confidence: 97%

Dress Syndrome Induced by Antiepileptic Drugs in Hospitals in Bukavu: About Two Cases

Semikenke¹

2018

JOJDC

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“…L'atteinte multiviscérale distingue le DRESS syndrome des réactions cutanées médicamenteuses communes (toxidermies) et le classe dans la catégorie des réactions cutanées médicamenteuses graves avec une mortalité globale évaluée à 10% par défaillance viscérale liée à une infiltration éosinophilique [ 6 ]. L'atteinte hépatique représente l'atteinte viscérale la plus fréquente et la principale cause de mortalité [ 7 , 8 ]. Une cytolyse est retrouvée dans plus de 80% des cas.…”

Section: Discussionunclassified

“…Une atteinte cholestatique pure avec ictère est plus rare. Une détérioration de la fonction hépatique avec baisse du taux de prothrombine signe une forme grave, parfois mortelle [ 8 ]. Chez nos patients, l'atteinte hépatique était constante.…”

Section: Discussionunclassified

DRESS syndrome: à propos de trois observations

Chebbi¹,

Souissi²,

Chelli³

et al. 2014

Pan Afr Med J

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Le syndrome d'hypersensibilité médicamenteuse ou Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) est une toxidermie rare mais sévère. Nous rapportons trois observations de DRESS syndromes secondaires à la prise de carbamazipine dans deux cas et de salazopyrine dans un cas. Le délai moyen entre la prise médicamenteuse et la survenue du DRESS syndrome était de six semaines. Le médicament incriminé était arrêté d'une façon définitive dans tous les cas. Une corticothérapie par voie générale était instaurée chez tous les patients devant l'atteinte hépatique sévère. L’évolution était favorable avec disparation des lésions cutanées et normalisation du bilan hépatique. Le diagnostic du syndrome DRESS doit être évoqué devant un tableau associant une éruption fébrile et des signes systémiques faisant suite à une prise médicamenteuse. La précocité du diagnostic est fondamentale pour l'arrêt définitif des médicaments suspects. Le traitement n'est pas bien codifié mais repose actuellement sur la corticothérapie générale.

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Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Sharifzadeh

Mohammadpour

Tavanaee

et al. 2020

Eur J Clin Pharmacol

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Background Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially lifethreatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, various reports of antibiotic-induced DRESS are available. In this review, we try to summarize reports of antibacterial antibiotic-induced DRESS focusing on characteristics of DRESS induced by each antibiotic group. Methods The data were collected by searching PubMed/MEDLINE and ScienceDirect. The keywords used as search terms were "DRESS syndrome," "drug-induced hypersensitivity syndrome (DIHS)," "antibiotics," "antimicrobial," and names of various antimicrobial groups. Finally, 254 relevant cases with a definite or probable diagnosis of DRESS based on RegiSCAR criteria were found until 30 May 2020 and reviewed. Results and conclusion Totally, 254 cases of antibacterial antibiotic-induced DRESS are reported. Most of them are related to antituberculosis drugs, vancomycin, and sulfonamides, respectively. Rash and fever were most frequent clinical findings. Eosinophilia and liver injury were the most reported hematologic and visceral organ involvement, respectively. Most of the patients are managed with systemic corticosteroids. The death occurred in 16 patients which most of them experienced liver or lung involvement. The reactivation of various viruses especially HHV-6 is reported in 33 cases. The mean latency period was 29 days. It is necessary to perform thorough epidemiological, genetic, and immunological studies, also systematic case review and causality assessment, as well as well-designed clinical trials for better management of antibiotic-induced DRESS.

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Hépatite cholestatique sévère révélant un Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome

Cited by 10 publications

References 14 publications

Dress Syndrome Induced by Antiepileptic Drugs in Hospitals in Bukavu: About Two Cases

Dress Syndrome Induced by Antiepileptic Drugs in Hospitals in Bukavu: About Two Cases

DRESS syndrome: à propos de trois observations

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

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