Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Abstract

Background Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially lifethreatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, various reports of antibiotic-induced DRESS are available. In this review, we try to summarize reports of antibacterial antibiotic-induced DRESS focusing on characteristics of DRESS induced by each antibiotic group. Methods The data were collected by searching PubMed/MEDLINE and ScienceDirect. The keywords used as search terms were "DRESS syndrome," "drug-induced hypersensitivity syndrome (DIHS)," "antibiotics," "antimicrobial," and names of various antimicrobial groups. Finally, 254 relevant cases with a definite or probable diagnosis of DRESS based on RegiSCAR criteria were found until 30 May 2020 and reviewed. Results and conclusion Totally, 254 cases of antibacterial antibiotic-induced DRESS are reported. Most of them are related to antituberculosis drugs, vancomycin, and sulfonamides, respectively. Rash and fever were most frequent clinical findings. Eosinophilia and liver injury were the most reported hematologic and visceral organ involvement, respectively. Most of the patients are managed with systemic corticosteroids. The death occurred in 16 patients which most of them experienced liver or lung involvement. The reactivation of various viruses especially HHV-6 is reported in 33 cases. The mean latency period was 29 days. It is necessary to perform thorough epidemiological, genetic, and immunological studies, also systematic case review and causality assessment, as well as well-designed clinical trials for better management of antibiotic-induced DRESS.

Multisystem Inflammatory Syndrome Associated with SARS-CoV-2 Infection in an Adult: A Case Report from the Maldives

“…In addition to this, there was no contact with animals (rodents) or any exposure to floods that would indicate possible etiological agents of rickettsiosis and leptospirosis. Non-infectious differential diagnoses to be considered would be drug reaction, eosinophilia, and systemic symptoms (DRESS) [ 42 ]. However, the rash appeared before using antibiotics, and he did not meet any of the criteria for DRESS.…”

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“…Dapsone-induced DRESS rate is 0.2-0.5% and it has the longest latency period between antibiotics that induced DRESS. In many reported cases the latency period for dapsone was around 4 months in our case it was 12 months [26].…”

Beta-lactam antibiotics as reserve medications for the treatment of drug-resistant tuberculosis

“…Sharifzadeh и соавт. [54] описывают особую реакцию организма с эозинофилией и системными симптомами (DRESS), также известную как синдром лекарственно-индуцированной гиперчувствительности. Сравнивая распространённость DRESS между различными группами антимикробных препаратов, оказалось, что в этом списке лидируют противотуберкулёзные препараты (42,13%), а на долю карбапенемов приходится 1,18%.…”