Determination of free desmosine in human plasma and its application in two experimental medicine studies

Lamerz, Jens; Friedlein, Arno; Soder, Nicole; Cutler, Paul; Döbeli, Heinz

doi:10.1016/j.ab.2013.01.012

Cited by 24 publications

(6 citation statements)

References 22 publications

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“…Using desmosine analysis as a measure of elastin quantity , clinically healthy animals of a susceptible breed were shown to have lower quantities of elastin than those of a nonsusceptible breed . Dermal changes were comparable in both the neck and the limb in horses of susceptible breeds (although more distinct in the limb).…”

Section: Pathogenesismentioning

confidence: 97%

Chronic progressive lymphoedema in draught horses

Keyser

Janssens

Buys

2014

Equine Veterinary Journal

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The objective of this review was to summarise and evaluate the current state of knowledge about chronic progressive lymphoedema in draught horses. Clinical signs of this multifactorial disorder are mainly restricted to the lower limbs, comprising progressively deteriorating skin, swelling and deformation. Although typical lesions were first reported at the beginning of the 20th century, chronic progressive lymphoedema was recognised as a specific syndrome only in 2003, and since then research has driven forward. Despite the high prevalence in some breeds and the serious economic impact, the pathogenesis is not fully understood, and the available treatment options remain symptomatic and noncurative. There is a need to improve diagnostic techniques and to develop selection tools.

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Section: Pathogenesismentioning

confidence: 97%

Chronic progressive lymphoedema in draught horses

Keyser

Janssens

Buys

2014

Equine Veterinary Journal

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“…Guzel et al mentioned expressing the result as the average of both peptides measured , while Sprung et al used the sum of the four transitions for a given peptide . An option for handling this type of data is to use linear mixed‐effects models . However, to our knowledge, none of the SRM methods on FFPE tissues cited here have used this strategy yet.…”

Section: Protein Quantification In Ffpe Tissues Using Targeted Ms Appmentioning

confidence: 99%

Applications of mass spectrometry for quantitative protein analysis in formalin‐fixed paraffin‐embedded tissues

et al. 2014

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Proteomic analysis of tissues has advanced in recent years as instruments and methodologies have evolved. The ability to retrieve peptides from formalin-fixed paraffin-embedded tissues followed by shotgun or targeted proteomic analysis is offering new opportunities in biomedical research. In particular, access to large collections of clinically annotated samples should enable the detailed analysis of pathologically relevant tissues in a manner previously considered unfeasible. In this paper, we review the current status of proteomic analysis of formalin-fixed paraffin-embedded tissues with a particular focus on targeted approaches and the potential for this technique to be used in clinical research and clinical diagnosis. We also discuss the limitations and perspectives of the technique, particularly with regard to application in clinical diagnosis and drug discovery.

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“…A wide range of biomarkers have been identified for the onset of type 1 diabetes ( 14 – 24 ) by INNODIA; for risk prediction ( 14 , 15 , 17 – 21 ) and identification of patients at high-risk of type 2 diabetes ( 25 ) by SUMMIT, IMIDIA, DIRECT, and EMIF; for pancreatic β-cells function and protection by RHAPSODY ( 26 , 27 ) and INNODIA ( 14 , 16 , 22 – 24 ); for hyperglycemia by RHAPSODY ( 28 ); for protection, prediction, initiation, progression, patient stratification, and medicine efficacy of diabetic kidney disease (DKD) ( 29 , 30 ) by SUMMIT and BEAT-DKD ( 31 – 39 ); for development of cardiovascular disease (CVD) by SUMMIT ( 30 , 40 , 41 ); and for the development of diabetic retinopathy (DR) by SUMMIT ( 30 , 42 , 43 ).…”

Section: Resultsmentioning

confidence: 99%

Scientific Advances in Diabetes: The Impact of the Innovative Medicines Initiative

2021

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Diabetes Mellitus is one of the World Health Organization's priority diseases under research by the first and second programmes of Innovative Medicines Initiative, with the acronyms IMI1 and IMI2, respectively. Up to October of 2019, 13 projects were funded by IMI for Diabetes & Metabolic disorders, namely SUMMIT, IMIDIA, DIRECT, StemBANCC, EMIF, EBiSC, INNODIA, RHAPSODY, BEAT-DKD, LITMUS, Hypo-RESOLVE, IM2PACT, and CARDIATEAM. In general, a total of €447 249 438 was spent by IMI in the area of Diabetes. In order to prompt a better integration of achievements between the different projects, we perform a literature review and used three data sources, namely the official project's websites, the contact with the project's coordinators and co-coordinator, and the CORDIS database. From the 662 citations identified, 185 were included. The data collected were integrated into the objectives proposed for the four IMI2 program research axes: (1) target and biomarker identification, (2) innovative clinical trials paradigms, (3) innovative medicines, and (4) patient-tailored adherence programmes. The IMI funded projects identified new biomarkers, medical and research tools, determinants of inter-individual variability, relevant pathways, clinical trial designs, clinical endpoints, therapeutic targets and concepts, pharmacologic agents, large-scale production strategies, and patient-centered predictive models for diabetes and its complications. Taking into account the scientific data produced, we provided a joint vision with strategies for integrating personalized medicine into healthcare practice. The major limitations of this article were the large gap of data in the libraries on the official project websites and even the Cordis database was not complete and up to date.

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Determination of free desmosine in human plasma and its application in two experimental medicine studies

Cited by 24 publications

References 22 publications

Chronic progressive lymphoedema in draught horses

Chronic progressive lymphoedema in draught horses

Applications of mass spectrometry for quantitative protein analysis in formalin‐fixed paraffin‐embedded tissues

Scientific Advances in Diabetes: The Impact of the Innovative Medicines Initiative

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