“…Our extensive standardised sonographic protocol, allowed us to obtain a better classification and differentiation of the extent of nerve hypertrophy between CMT-1A and HNPP. Several studies reported nerve hypertrophy in median nerves (Heinemeyer and Reimers, 1999;Martinoli et al, 2002;Zaidman et al, 2009Zaidman et al, , 2013Pazzaglia et al, 2013;Schreiber et al, 2013;Sugimoto et al, 2013), ulnar nerves (Heinemeyer and Reimers, 1999;Zaidman et al, 2009Zaidman et al, , 2013Pazzaglia et al, 2013;Sugimoto et al, 2013), radial (Heinemeyer and Reimers, 1999), sciatic (Heinemeyer and Reimers, 1999) and sural nerves (Heinemeyer and Reimers, 1999;Pazzaglia et al, 2013) in CMT-1A patients. This is the first study to systematically evaluate and quantitate multiple morphological aspects of the main arm and leg nerves: nerve and fascicle size, vascularisation and echogenicity.…”