Ultrasound and electrophysiologic findings in patients with Guillain–Barré syndrome at disease onset and over a period of six months

Grimm, Alexander; Décard, Bernhard F.; Schramm, Axel; Pröbstel, Anne-Katrin; Rasenack, Maria; Axer, Hubertus; Fuhr, Peter

doi:10.1016/j.clinph.2015.06.032

Cited by 69 publications

(62 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Grimm et al . observed CSAs at a third of the size of those reported by Cartwright et al ., ranging between 2.0 and 2.2 mm 2 . This relevant discrepancy may be at least partially explained by differing study cohorts.…”

Section: Discussionmentioning

confidence: 96%

“…This is particularly applicable to the vagus nerve (VN) . Currently, only 2 ultrasound laboratories have reported reference values for VNs in healthy participants, with mean cross‐sectional areas (CSAs) varying widely between 2.0 mm 2 and 5.9 mm 2 . These reported differences may be partly attributed to the use of different ultrasound systems, varying measurement levels (ML), different methods of assessing CSA, and differences in the study populations.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Sonographic evaluation of the vagus nerves: Protocol, reference values, and side‐to‐side differences

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Sonographic evaluation of the vagus nerves: Protocol, reference values, and side‐to‐side differences

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Selective lesions in proximal nerve trunks may explain the discrepancy between nerve conduction and the established paralysis, as elegantly illustrated in electrophysiological [75] and ultrasonographic [76,77] studies of the ventral spinal nerves in AIDP and AMAN/AMSAN. The sensory nerve conduction study of sural nerve is normal in greater proportion of patients [78].…”

Section: Diagnosismentioning

confidence: 99%

Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment

Jasti

Selmi

Sarmiento-Monroy

et al. 2016

Expert Review of Clinical Immunology

114

View full text Add to dashboard Cite

Guillain-Barré syndrome is a rare disease representing the most frequent cause of acute flaccid symmetrical weakness of the limbs and areflexia usually reaching its peak within a month. The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9-17% of cases despite immunotherapy. Areas covered: In terms of etiology, Guillain-Barré syndrome is linked to Campylobacter infection but less than 0.1% of infections result in the syndrome. In terms of pathogenesis, activated macrophages and T cells and serum antibodies against gangliosides are observed but their significance is unclear. Expert commentary: Guillain-Barré syndrome is a heterogeneous condition with numerous subtypes and recent data point towards the role of ganglioside epitopes by immunohistochemical methods. Ultimately, the syndrome results from a permissive genetic background on which environmental factors, including infections, vaccination and the influence of aging, lead to disease.

show abstract

“…High‐resolution ultrasound (HR‐US) is the method of choice for imaging small cervical and peripheral nerves . Such imaging is relevant for: (i) localization to avoid harm during invasive procedures, (ii) localization to target therapeutics, and (iii) measuring nerve caliber for assessing compressive, inflammatory or degenerative neuropathies . For example, mild to moderate atrophy of the vagus nerve has been detected on HR‐US in amyotrophic lateral sclerosis and in diabetic neuropathy .…”

mentioning

confidence: 99%

Differential age‐, gender‐, and side‐dependency of vagus, spinal accessory, and phrenic nerve calibers detected with precise ultrasonography measures

Walter

Tsiberidou

2019

Muscle and Nerve

View full text Add to dashboard Cite

Introduction: The standard ultrasonographic measurement tools (trace, ellipse) of cross‐sectional areas (CSAs) of very small nerves typically yield rough measures in full square millimeters. Methods: In 70 volunteers, the elliptically shaped CSAs of mid‐cervical vagus, accessory, and phrenic nerves were estimated with three methods: 2 on‐board tools (area tracing, ellipse fitting) and an off‐line calculation of the CSA after on‐board measuring of its long‐axis and short‐axis diameters both displayed with 1‐2 digits following the decimal point. Results: CSA measures of all mid‐cervical nerves obtained with the precise approach were smaller than the two standard measures (each P < 0.001). Larger CSA of right compared to left vagus nerve was detected with all methods. However, decrease of accessory and phrenic nerve CSAs with increasing age and larger size of vagus nerve CSA in women vs. men were evident only with precise measures. Discussion: Small nerve CSA should preferably be estimated with precise measures. Muscle Nerve 59:486–491, 2019

show abstract

Ultrasound and electrophysiologic findings in patients with Guillain–Barré syndrome at disease onset and over a period of six months

Cited by 69 publications

References 34 publications

Sonographic evaluation of the vagus nerves: Protocol, reference values, and side‐to‐side differences

Sonographic evaluation of the vagus nerves: Protocol, reference values, and side‐to‐side differences

Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment

Differential age‐, gender‐, and side‐dependency of vagus, spinal accessory, and phrenic nerve calibers detected with precise ultrasonography measures

Contact Info

Product

Resources

About