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Keck, James L.

doi:10.1038/13260

Cited by 11 publications

(1 citation statement)

References 20 publications

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“…While its members are relatively thin on the ground they are very influential, as they control the institutions that provide the official definition of reality. 15 Berger's observation is critical for this discussion. Development theories and the practices of international development agencies have a profound impact on nations around the world, particularly in the global South.…”

Section: Spiritual Assets and Dominant World Viewsmentioning

confidence: 97%

In Search of the Spirit in Spiritual Assets

Smith

2014

Transformation

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This article discusses the concept of spiritual assets or spiritual capital in community development and social transformation. It argues that much of the existing discourse on the subject tends to be reductionist in its approach, often limiting discussion of spiritual assets to the social and cultural capital of religious organizations. The study proposes an understanding of spiritual assets which acknowledges the creative and sustaining work of the Spirit in enabling and motivating communities to envision, and discern paths of renewal and social transformation.

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Section: Spiritual Assets and Dominant World Viewsmentioning

confidence: 97%

In Search of the Spirit in Spiritual Assets

Smith

2014

Transformation

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Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases

et al. 2015

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Methyleugenol is a substituted alkenylbenzene found in several herbs and spices. It is classified by the European Union's Scientific Committee on Food as a genotoxic carcinogen. We addressed the biological mechanism of the genotoxic properties of methyleugenol and its oxidative metabolites. Methyleugenol and the oxidative metabolites significantly enhanced the DNA damage in human colon carcinoma cells (HT29). Methyleugenol did not affect the protein status of γH2AX, a biomarker of DNA double-strand breaks, whereas its metabolites methyleugenol-2',3'-epoxide and 3'-oxomethylisoeugenol significantly increased the cellular phosphorylated H2AX level. Both of these metabolites also showed a significant induction of micronuclei in HT29 cells. Furthermore, we investigated whether topoisomerase interaction contribute to the observed effect on DNA integrity. Methyleugenol-2',3'-epoxide and 3'-oxomethylisoeugenol inhibited the activity of recombinant topoisomerase I. In HT29 cells, neither methyleugenol nor the metabolites affected the level of topoisomerase protein bound to DNA, excluding a topoisomerase poisoning mode of action. In addition, 3'-oxomethylisoeugenol potently diminished the level of camptothecin-stabilized topoisomerase I/DNA intermediates and camptothecin-induced DNA strand breaks. In conclusion, it could be suggested that 3'-oxomethylisoeugenol may also interact with classical or food-borne topoisomerase I poisons, diminishing their poisoning effectiveness.

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