Clinical Studies of Camptothecin and Derivatives

Soepenberg, Otto; Sparreboom, Alex; Verweij, Jaap

doi:10.1016/s0099-9598(03)60001-5

Cited by 11 publications

(11 citation statements)

References 241 publications

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“…However, many side effects were also observed in those assays. For instance, CPT is a water-insoluble (0.551 mg/mL) molecule and has no specific targeting ability towards tumor cells, which causes damage to healthy tissues near the tumor [38]. Additionally, CPT has low tumor penetration ability, which means that only the surface of the tumor tissue can be treated.…”

Section: Camptothecinsmentioning

confidence: 99%

“…Afterwards, the mechanisms of action for CPT were revealed. CPT can selectively combine with the nuclear DNA topoisomerase types I and DNA complexes and then stabilize them to induce the failure re-ligation of DNA, which causes DNA eradication and results in cell apoptosis [38]. Later, many artificial CPT derivatives were designed and synthesized.…”

Section: Camptothecinsmentioning

confidence: 99%

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Molecular Engineering of Peptide–Drug Conjugates for Therapeutics

Fang

Wang

2022

Pharmaceutics

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In recent years, hundreds of novel small molecular drugs used for different treatments have been studied in the three phases of clinical trials around the world. However, less than 10% of them are eventually used due to diverse problems. Even some traditional drugs that have been approved by the Food and Drug Administration (FDA) have faced similar dilemmas. For instance, many drugs have poor water solubility, are easily hydrolyzed, or possess undesirable toxicity, while a variety of cancer cells develop drug resistance (DR) or multiple drug resistance (MDR) towards chemotherapeutic agents after long-term therapy. In order to improve the efficacy and efficiency of drugs, research has been directed forward towards the creation of assemblies of peptide–drug conjugates (PDCs) which have proven to possess wide potential for overcoming such complications based on their excellent biocompatibility, controllable biodegradability, site-selective targeting, and comparably low cytotoxicity. In this review, we focus on the recent developments and advances made in the creation of self-assembled nanostructures of PDCs for cancer therapy, on the chemical and physical properties of such drugs and peptides, and how they are arranged together to form diverse supramolecular nanostructures. Additionally, we cover certain mechanisms regarding how peptides or their derivatives enhance the efficiency and efficacy of those selected drugs and provide a brief discussion regarding the perspectives and remaining challenges in this intriguing field.

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Section: Camptothecinsmentioning

confidence: 99%

Section: Camptothecinsmentioning

confidence: 99%

Molecular Engineering of Peptide–Drug Conjugates for Therapeutics

Fang

Wang

2022

Pharmaceutics

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“…The principle of this approach has been shown for camptothecin. The most promising derivatives are 9-[(dimethylamino)methyl]-10-hydroxy camptothecin (topotecan) and 7ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyl oxy camptothecin (irinotecan), which exhibit a much better water solubility than camptothecin [22]. Camptothecin can be found in most parts of C. acuminata, e.g., roots, root barks, fruits, and leaves, but it is especially abundant in seeds.…”

Section: Phytochemistrymentioning

confidence: 99%

Molecular Target-Guided Tumor Therapy with Natural Products Derived from Traditional Chinese Medicine

Efferth¹,

Fu²,

Yuan-Gang³

et al. 2007

CMC

114

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A tremendous interest exists in the Western world in Traditional Chinese Medicine (TCM) with rapidly increasing export rates of TCM products from China to Europe and USA. This led to a national decision of the Chinese government to implement a "Plan for the Modernization of Chinese Medicine". Concerning the use of Chinese medicinal herbs, two major directions can be distinguished. One field is phytochemistry and pharmacognosy. Secondary metabolites isolated from Chinese plants can be easily subjected to pharmacological, molecular biological, and pharmacogenomic analyses using methods of modern cell and molecular biology as exemplified for camptothecin from Camptotheca acuminata in the present review. The second field of interest is phytomedicine. Standardized international quality guidelines help to improve quality, safety and efficacy of Chinese medicinal herbs. Sustainability of natural products from TCM can be reached by breeding high-yield varieties or by biotechnological approaches. In the long term, natural products from TCM can contribute to the development of molecular target-guided therapies and individualized treatment strategies.

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“…Carboxylic acid or its sodium salt, even though soluble, has considerably lower antitumor potential as compared to CPT. Furthermore, this ionic form favorably binds to the human serum albumin, lowering the accessible drug concentration [ 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Improved Anticancer Efficacies of Camptothecin Nano-Formulations: A Systematic Review

Ghanbari-Movahed

Kaceli

Mondal³

et al. 2021

Biomedicines

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Camptothecin (CPT), a natural plant alkaloid, has indicated potent antitumor activities via targeting intracellular topoisomerase I. The promise that CPT holds in therapies is restricted through factors that include lactone ring instability and water insolubility, which limits the drug oral solubility and bioavailability in blood plasma. Novel strategies involving CPT pharmacological and low doses combined with nanoparticles have indicated potent anticancer activity in vitro and in vivo. This systematic review aims to provide a comprehensive and critical evaluation of the anticancer ability of nano-CPT in various cancers as a novel and more efficient natural compound for drug development. Studies were identified through systematic searches of PubMed, Scopus, and ScienceDirect. Eligibility checks were performed based on predefined selection criteria. Eighty-two papers were included in this systematic review. There was strong evidence for the association between antitumor activity and CPT treatment. Furthermore, studies indicated that CPT nano-formulations have higher antitumor activity in comparison to free CPT, which results in enhanced efficacy for cancer treatment. The results of our study indicate that CPT nano-formulations are a potent candidate for cancer treatment and may provide further support for the clinical application of natural antitumor agents with passive targeting of tumors in the future.

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Clinical Studies of Camptothecin and Derivatives

Cited by 11 publications

References 241 publications

Molecular Engineering of Peptide–Drug Conjugates for Therapeutics

Molecular Engineering of Peptide–Drug Conjugates for Therapeutics

Molecular Target-Guided Tumor Therapy with Natural Products Derived from Traditional Chinese Medicine

Recent Advances in Improved Anticancer Efficacies of Camptothecin Nano-Formulations: A Systematic Review

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