Effects of Quercetin Supplementation on Endurance Performance and Maximal Oxygen Consumption: A Meta-Analysis

Pelletier, Denis M.; Lacerte, Guillaume; Goulet, Eric

doi:10.1123/ijsnem.23.1.73

Cited by 26 publications

(23 citation statements)

References 41 publications

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“…Quercetin also has a remarkably broad range of physiological actions (Table ) . The following sections describe some of the major areas in which quercetin alters both normal and pathologic physiology.…”

Section: Biological Properties Of Quercetin: Mammalian Cellsmentioning

confidence: 99%

“…A much larger study might correct for these influences and reveal more significant changes. In light of the somewhat disparate findings on quercetin and exercise endurance/recovery, Pelletier et al . conducted a meta‐analysis of studies that examined the effect of quercetin supplementation on endurance performance and maximal oxygen consumption.…”

Section: Biological Properties Of Quercetin: Mammalian Cellsmentioning

confidence: 99%

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Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease

2014

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There is a growing realization that natural products such as phytochemicals can be used in diets or as supplements to prevent or treat human disease. The disciplines of epidemiology, pharmacognosy, and molecular biology have provided evidence that certain dietary constituents decrease blood pressure, influence immune and neuronal function, affect the incidence of cancer, and ameliorate the abnormal properties of cancer cells. Molecular studies have uncovered the interesting feature that most phytochemicals have multiple modes of action. This review focuses on the flavonoid phytochemical quercetin and describes the myriad of conditions in which quercetin affects a number of physiological processes. Despite the compelling information available, including a number of animal studies, translation of these findings into human clinical trials has been slow. The status of current clinical research on quercetin is summarized, and direction for further research is suggested.

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Section: Biological Properties Of Quercetin: Mammalian Cellsmentioning

confidence: 99%

Section: Biological Properties Of Quercetin: Mammalian Cellsmentioning

confidence: 99%

Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease

2014

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“…Currently, quercetin as aglycone is marketed as an ingredient of dietary supplements with different claims or purported benefits which are not within the focus of the present review and reviewed elsewhere . However, the European Commission did not authorize certain health claims, e.g., for protection of DNA, proteins, and lipids from oxidative damage for the general population .…”

Section: Introductionmentioning

confidence: 99%

Safety Aspects of the Use of Quercetin as a Dietary Supplement

Andres

Pevny

Ziegenhagen

et al. 2017

Molecular Nutrition Food Res

353

219

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The flavonoid quercetin is frequently found in low amounts as a secondary plant metabolite in fruits and vegetables. Isolated quercetin is also marketed as a dietary supplement, mostly as the free quercetin aglycone, and frequently in daily doses of up to 1000 mg d -1 exceeding usual dietary intake levels. The present review is dedicated to safety aspects of isolated quercetin used as single compound in dietary supplements. Among the numerous published human intervention studies, adverse effects following supplemental quercetin intake have been rarely reported and any such effects were mild in nature. Published adequate scientific data for safety assessment in regard to the long-term use (>12 weeks) of high supplemental quercetin doses (ࣙ1000 mg) are currently not available. Based on animal studies involving oral quercetin application some possible critical safety aspects could be identified such as the potential of quercetin to enhance nephrotoxic effects in the predamaged kidney or to promote tumor development especially in estrogen-dependent cancer. Furthermore, animal and human studies with single time or short-term supplemental quercetin application revealed interactions between quercetin and certain drugs leading to altered drug bioavailability. Based on these results, some potential risk groups are discussed in the present review.

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“…Quercetin has been proposed as an ergogenic supplement for athletes because it may mimic training‐induced mitochondrial biogenesis in skeletal muscle (Davis et al., ). Recent meta‐analyses of the currently available literature have concluded that chronic quercetin supplementation appears to improve aerobic capacity and endurance performance, with significant differences seen in untrained populations, but not trained groups (Kressler et al., ; Pelletier et al., ). However, even when the effects are statistically significant, the magnitude of change is trivial to small and unlikely to have real‐world significance (Pelletier et al., ).…”

mentioning

confidence: 99%

Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training

Casuso

López

Nordsborg

et al. 2013

Scandinavian Med Sci Sports

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We aimed to test exercise-induced adaptations on skeletal muscle when quercetin is supplemented. Four groups of rats were tested: quercetin sedentary, quercetin exercised, placebo sedentary, and placebo exercised. Treadmill exercise training took place 5 days a week for 6 weeks. Quercetin groups were supplemented with quercetin, via gavage, on alternate days throughout the experimental period. Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor γ coactivator-1α mRNA levels, mitochondrial DNA (mtDNA) content, and citrate synthase (CS) activity were measured on quadriceps muscle. Redox status was also quantified by measuring muscle antioxidant enzymatic activity and oxidative damage product, such as protein carbonyl content (PCC). Quercetin supplementation increased oxidative damage in both exercised and sedentary rats by inducing higher amounts of PCC (P < 0.001). Quercetin supplementation caused higher catalase (P < 0.001) and superoxide dismutase (P < 0.05) activity in the non-exercised animals, but not when quercetin is supplemented during exercise. Quercetin supplementation increased SIRT1 expression, but when quercetin is supplemented during exercise, this effect is abolished (P < 0.001). The combination of exercise and quercetin supplementation caused lower (P < 0.05) mtDNA content and CS activity when compared with exercise alone. Quercetin supplementation during exercise provides a disadvantage to exercise-induced muscle adaptations.

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Effects of Quercetin Supplementation on Endurance Performance and Maximal Oxygen Consumption: A Meta-Analysis

Cited by 26 publications

References 41 publications

Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease

Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease

Safety Aspects of the Use of Quercetin as a Dietary Supplement

Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training

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