Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease

Abstract

There is a growing realization that natural products such as phytochemicals can be used in diets or as supplements to prevent or treat human disease. The disciplines of epidemiology, pharmacognosy, and molecular biology have provided evidence that certain dietary constituents decrease blood pressure, influence immune and neuronal function, affect the incidence of cancer, and ameliorate the abnormal properties of cancer cells. Molecular studies have uncovered the interesting feature that most phytochemicals have multiple modes of action. This review focuses on the flavonoid phytochemical quercetin and describes the myriad of conditions in which quercetin affects a number of physiological processes. Despite the compelling information available, including a number of animal studies, translation of these findings into human clinical trials has been slow. The status of current clinical research on quercetin is summarized, and direction for further research is suggested.

Marker Based Analytical Studies on Rasam: A South Indian Traditional Functional Food

“…[26,27] Quercetin has been studied for the treatment of cancer and various other diseases, there is no evidence that quercetin (via supplements or in food) is useful to treat cancer or any disease. [28,29] Hence, quercetin was studied as a chemical marker in rasam.…”

Humoral Immune Reactivity Disorders in Experimental Parodontitis and Their Correction by Flavonol

“…The corvitin (quercetin) is classified as flavonols with antioxidant, anti-ischemic, membranestabilizing and immunomodulating properties [3,14]. It has a large reduction potential and exhibits antiinflammatory, anabolic, anti-apoptotic features [10,13].…”

The expediency substantiation of the resveratrol and quercetin polyphenols use in ischemic heart disease combined with autoimmune thyroiditis. Part I

“…Для фармацевтики кверцетин получают путем гидро-лиза рутина, выделенного из софоры китайской или гречихи [30]. Обладая подобным ресвератро-лу спектром фармакологического действия, квер-цетин имеет индивидуальные отличия: обладает рутиноподобным мембраностабилизирующим действием, антилейкотриеновой активностью [32][33][34]. Кверцетин способен повышать биодоступ-ность и кумулятивные свойства ресвератрола при комбинированном применении [23,24].…”

“…Исследования кверцетина как антиокси-данта начались несколько десятилетий назад и активно продолжаются по разным направлени-ям его фармакологической активности [33,34,48]. Проведенный мета-анализ проспективных когортных исследований продемонстрировал связь приёма кверцетина с более низкими показа-телями заболеваемости ИБС и снижением риска развития инсульта [49,50].…”