2% propofol for sedation in the intensive care unit

Abstract

SummaryA 2% solution of propojol has been compared with the I% fiwmulation for sedation in patients whose lungs were being mechanicolly ventilated in an intensive care unit ,fbIlowing coronary artery bypass surgery. There were no significant di3erences in the amount qfprop?fol used in the two groups, the rate of propofid infusion or the number of changes made to the infusion rate to maintain the desired level of sedation. Recovery times and times to tracheal extubation were similar. The mean heart rates of those receiving 2% propofd were significantly higher throughout the period of the study for no apparent reason. Propofbl 2% n.as ,found to be sufi. easy to administer and a practical alternative to Ihe I% solution .for sedating cardiuc surgicul patients.

Sedation in the Intensive Care Unit

“…We identified 49 randomized controlled trials, 41 from personal file, MEDLINE, and EMBASE searches, 7 more from hand searching anesthesia journals, and 1 from an expert in the field. Of the 49 trials, 17 were excluded [52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68] (4 addressed a different population [52][53][54][55][56] [2 normal volunteers, 1 nonventilated ICU patients, 1 intraoperative cardiac surgery anesthesia patients], 2 evaluated different outcomes 57,58 [renal function of isoflurane, urine, and plasma catecholamines], and 6 investigated dif-ferent dosing schedules or modes of administering a single agent [59][60][61][62][63][64][65][66][67][68] ), leaving 32 trials for analysis.…”