2-(3-Amino-3-deoxy-β-d-xylofuranosyl)thiazole-4-carboxamide: A new tiazofurin analogue with potent antitumour activity

Multifunctional biomass-based chemicals: H2S scavenging

“…Only very few examples of nitrile-containing carbohydrates have been reacted with H 2 S. A rare example is given by Popsavin et al, who synthesized a thiazofurin derivative from xylofuranosyl cyanide to get the corresponding thioamide for the construction of a thiazole. 18 There are, however, no examples of nitriles or nitrile-containing carbohydrates used for H 2 S scavenging. Linking nitriles with carbohydrates most obviously involves C-O bond formation and in order to limit waste, catalytic reactions were preferred.…”

“…Only very few examples of nitrile-containing carbohydrates have been reacted with H 2 S. A rare example is given by Popsavin et al , who synthesized a thiazofurin derivative from xylofuranosyl cyanide to get the corresponding thioamide for the construction of a thiazole. 18…”

Synthesis of 5-(Thiazol-5-yl)-4,5-dihydroisoxazoles from 3-Chloropentane-2,4-dione

“…For example, thiazoles are an important motif in compounds with anticancer, antifungal, antibiotic, and antiviral activities, and isoxazoline-containing small molecules are known to educe anti-inflammatory, herbicidal, and fungicidal effects . Metabolic processing of the isoxazoline moiety has also been exploited in an antedrug application .…”

Synthesis and antitubercular activity of 4-oxo-thiazolidine derivatives of 2-amino-5-nitrothiazole

“…Thiazole moiety is the key pharmacophore for the synthesis of several biological important molecules. Thiazole containing derivatives plays an important role in biological activity of many compounds such as antimicrobial activity [1,2], anti-inflammatory [3], antitumor activities [4], antiarrhythmic and anticoagulant activities [5]. We also knows that imine derivatives possess potent activities including antibacterial [6,7], antifungal [8,9] and antitubercular [10] activities.…”